We measured serum concentrations of trace elements and evaluated their clinical significance in relation to treatment outcomes critically ill patients. A total 167 participants (105 men 62 women; average age, 61.4 years; age range, 18-90 years) were enrolled. Arterial blood the zinc, copper, selenium, manganese every 14 days. At time intensive care unit (ICU) admission, lower than normal values 75.1, 1.8, 37.8, 2.1% patients, respectively. Serum element on day ICU stay higher those at...

The purpose of this study was to examine the effectiveness and safety combined treatment using acupuncture bee venom (BVA) as an adjunctive for idiopathic Parkinson's disease (PD).Eleven patients (7 men 4 women) with PD who had been receiving a stable dose anti-parkinsonian medication at least weeks. Participants received conventional 12 Subsequently, they additional BVA twice weekly weeks while still maintaining treatment. All participants were assessed baseline, weeks, 24 by Unified...

Abstract Sarcopenia is an age-related disorder characterised by a progressive decrease in skeletal muscle mass. As the genetic biomarkers for sarcopenia are not yet well characterised, this study aimed to investigate variations related relatively aged cohort, using genome-wide association (GWAS) meta-analyses of lean body mass (LBM) 6961 subjects. Two Korean cohorts were analysed, and subgroup GWAS was conducted appendicular (ASM) index. The effects significant single nucleotide...

Objectives This study aims to identify factors that influence the happiness of Korean adults who have difficulty sleeping, providing a foundation for initiatives promote their overall well-being. Methods utilized data from 3rd year 8th Korea National Health and Nutrition Examination Survey (2021) analyze affecting in aged 40 older with sleeping. Happiness status was examined through complex sample frequency analysis, differences by general characteristics were analyzed using Rao-Scott...

Though Dieckol, a phlorotannin of Ecklonia cava, was known to have antioxidant, anticancer, antidiabetic, and anti-inflammatory effects, the underlying antifibrotic mechanism Dieckol still remains unclear until now. Thus, in current study, inhibitory on liver fibrosis elucidated mainly hepatic stellate cells (HSCs). exerted cytotoxicity LX-2, HSC-T6, HepG2 with reduced features large, spread out, flattened polygonal shapes LX-2 compared untreated control. attenuated expression α-SMA TGF-β1,...

Abstract Background Sarcopenia is characterized by a progressive decrease in skeletal muscle mass and function with age. Given that sarcopenia associated various metabolic disorders, effective biomarkers for its early detection are required. We aimed to investigate the related elderly men perform experimental studies using metabolomics. Methods Plasma metabolites from 142 men, comprising group an age‐matched control group, were measured global metabolome profiling. Muscle plasma samples...

Though Dehydrocorydaline, an alkaloid isolated from Corydalis turtschaninovii tuber, was known to have anti-coronary artery disease, anti-inflammatory, apoptotic, anti-allergic, anti-acetylcholinesterase, and antitumor effects, the underlying anti-metastatic mechanism of Dehydrocorydalin never elucidated in lung cancer cells so far. Thus, present study, effect Dehydrocorydaline examined non-small cell carcinoma (NSCLC) cells, mainly targeting matrix metalloproteinases (MMPs) B lymphoma-2...

Beta-D-Xylosidase (EC 3.2.1.37) has been purified from ginsenoside Ra-metabolizing Bifidobacterium breve K-110, which was isolated human intestinal microflora. beta-D-Xylosidase to apparent homogeneity by a combination of ammonium sulfate precipitation, QAE-cellulose, butyl-toyopearl, hydroxyapatit and Q-Sepharose column chromatographies with the final specific activity 51.8 micromol/min/mg. Molecular weight beta-D-xylosidase is 49 kDa SDS-PAGE gel filtration, consisted single subunit....

Krill oil is a novel, commercially available marine rich in long-chain polyunsaturated omega-3 fatty acids, particularly eicosapentaenoic acid and docosahexaenoic acid. Compared with fish oil, the effects of krill supplementation on human health its underlying action mechanisms are currently poorly understood. In present study, we examined effect metabolic parameters mice fed high-fat diet (HFD). HFD for 10 weeks resulted an ∼15% lower body weight gain dramatic suppression hepatic steatosis....

Though Atorvastatin has been used as a hypolipidemic agent, its anticancer mechanisms for repurposing are not fully understood so far. Thus, in the current study, apoptotic and autophagic were investigated non-small cell lung cancers (NSCLCs). increased cytotoxicity, sub G1 population, number of bodies, cleaved poly (ADP-ribose) polymerase (PARP) caspase 3 activated p53 H1299, H596, H460 cells. Notably, inhibited expression c-Myc induced ribosomal protein L5 L11, but depletion reduced PARP...

// Jihyun Lee 1, * , Eun Jung Sohn Sangwook Yoon 1 Gunho Won Chang Geun Kim Ji Hoon Sung-Hoon College of Korean Medicine, Kyung Hee University, Dongdaemun-gu, Seoul, 130-701, Republic Korea These authors have contributed equally to this work Correspondence to: Kim, email: sungkim7@khu.ac.kr Keywords: tanshinone I, autophagy, p62 ΔUBA IRE1, mesothelioma cells Received: October 27, 2016 Accepted: January 16, 2017 Published: February 15, ABSTRACT The aim present study is elucidate autophagic...

Abstract Introduction: Malnutrition is prevalent in hemodialysis (HD) patients, and the risk of mortality strongly correlated with malnutrition. Current methods nutritional evaluation are mostly subjective, time‐consuming, cumbersome. Creatinine index (CI) geriatric (GNRI) very simple objective to assess status HD patients. The present study compares performance CI GNRI as assessment tools. Methods: Eighty‐eight patients end‐stage renal disease on were recruited from a single tertiary...

Background/Aims: Though CCR4-NOT2 (CNOT2), one of CCR4-NOT complex subunits, was known to be involved in metastasis and apoptosis through transcription mRNA degradation, its other biological function is poorly understood so far. The aim this study elucidate the molecular role CNOT2 differentiation process 3T3-L1 preadipocytes. Methods Results: overexpressed during Consistently, levels CNOT2, adiponectin, adiponectin 2, PPARγ CEBPα were enhanced adipocytes. Conversely, depletion by siRNA...

Abstract Though Farnesiferol c (FC) has been reported to have anti-angiogenic and antitumor activity, the underlying mechanism of FC still remains unclear. Thus, in present study, we investigated apoptotic human H1299 H596 non-small lung cancer cells (NSCLCs). significantly showed cytotoxicity, increased sub-G1 accumulation, attenuated expression Bcl-2, Bcl-xL, Survivin procaspase 3 cells. Furthermore, effectively suppressed mRNA G1 arrest related genes such as Cyclin D1, E2F1 transcription...

Though ergosterol peroxide (EP) derived from Neungyi mushrooms (Sarcodon aspratus) was known to have cytotoxic, apoptotic, anti-inflammatory and antimycobacterial effects, the underlying molecular mechanism of EP still remains unclear. Thus, in present study, apoptotic elucidated DU 145 prostate cancer cells.Cell viability cells measured by MTT assay. To see whether induces apoptosis, FACS, western blot TUNEL assay were performed. determine role Death receptor (DR) 5 molecules EP-induced...

Herein, the apoptotic mechanism of 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (PGG) was examined in cisplatin-resistant lung cancer cells. PGG significantly reduced viability; increased sub-G1 accumulation and number terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL)-positive cells; induced cleavage poly (ADP-ribose) polymerase (PARP), caspases (8,9,3,7), B-cell lymphoma protein 2 (Bcl-2)-associated X (Bax) phosphatase tensin homolog deleted on chromosome 10 (PTEN);...

Abstract Aims Major trauma patients need adequate nutrition for recovery. This study aimed to evaluate the adequacy of nutritional supply and correlation between clinical outcome. Methods A single‐centre retrospective observational was undertaken, describing amounts energy proteins provided 320 critically ill during first 10 days after admission. The data were collected from electronic medical records admitted intensive care unit period descriptive statistical analyses performed with SPSS...

This study was conducted to evaluate recent clinical and anthropologic features of neonates with reactive serology for syphilis their mothers from three institutions in Korea over an 11-year-period.The medical records 20 at centers (Kyung Hee University Hospital, Kyung Hospital Gangdong, Electric Power Corporation Hospital) seen between January 2000 December 2010 were reviewed retrospectively.Among mothers, 16 (80%) native Korean four (20%) foreign-born immigrants. Two (10%) unmarried. The...

Mobile manipulator is a robot for the next generation of processes. The mobile can increase process efficiency by being combined with collaborative system. However, due to worker safety issues, simultaneous control still difficult. In this paper, we present designing path collision avoidance workers. By monitoring position and velocity modeled as cylinder, designs avoid using reinforcement learning. We learned simulation, checked move destination avoiding worker.