A5041735371- Renal Diseases and Glomerulopathies
- Infant Nutrition and Health
- Breastfeeding Practices and Influences
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Immunodeficiency and Autoimmune Disorders
- Pediatric health and respiratory diseases
- Dialysis and Renal Disease Management
- Nutrition, Health and Food Behavior
- Chronic Kidney Disease and Diabetes
- Diabetes and associated disorders
- Educational Systems and Policies
- Neonatal and Maternal Infections
- Autoimmune Bullous Skin Diseases
- Neonatal and fetal brain pathology
- Systemic Lupus Erythematosus Research
- Renal and related cancers
- Wnt/β-catenin signaling in development and cancer
- Mast cells and histamine
- Streptococcal Infections and Treatments
- Sepsis Diagnosis and Treatment
- Child Nutrition and Feeding Issues
- Metabolomics and Mass Spectrometry Studies
- Child Nutrition and Water Access
- FOXO transcription factor regulation
Soonchunhyang University
2013-2024
Inha University Hospital
2024
Soonchunhyang University Hospital
2015-2024
Soon Chun Hyang University Cheonan Hospital
2013
Kyung Hee University
2004-2012
Foreign Service Institute
2005
Objectives: Human milk oligosaccharides (HMOs) are known as important factors in neurologic and immunologic development of neonates. Moreover, freeze-drying seems to be a promising storage method improve the processes human banks. However, effects pasteurization on HMOs were not evaluated yet. The purpose this study is analyze compare profiles collected before after freeze-drying.Methods: Totally nine fresh samples from three healthy mothers at first, second, third week delivery. treated...
The purpose of this study is to analyze the macronutrient human milk (HM) and find out various maternal-infantile factors that can affect HM composition.478 samples were collected from healthy exclusively breast-feeding mothers who delivered term neonates within 3 months. Macronutrient was analyzed birth data collected.In multivariate logistic regression analysis, found be associated with composition changes; higher fat: cesarean section (OR = 2.47, p < 0.001) height 0.84, 0.004); protein:...
Procalcitonin (PCT) has been reported as a sensitive marker for neonatal bacterial infections. Recently, small numbers of studies usefulness PCT/C-reactive protein (CRP) ratio in detection infectious conditions adults. Thus, we conducted this study to evaluate PCT/CRP late onset sepsis. Serum PCT and CRP was measured blood samples from 7 60 days after birth 106 neonates with sepsis 212 controls who were matched gestational age, postnatal weight, gender. Areas under ROC curve (AUC)...
We evaluated the association between macronutrients of human milk (HM), and interactions maternal age body mass index(BMI) in matched conditions.Totally, 80 HM samples were collected from healthy breast-feeding mothers at fourth week lactation. data analyzed. Mothers subgrouped into four groups by (20 s/30 s) BMI (overweight/normal).Two-way ANOVA revealed significant to affect macronutrients; fat, carbohydrate, calories. Moreover, different responses fat calorie found groups.The evaluation...
Diarrheal disease is one of the leading causes worldwide morbidity and mortality, especially in children. It loss body fluid, which may lead to severe dehydration, electrolyte imbalance, shock even death. The mortality rate from acute diarrhea has decreased over last few decades. This decline, developing countries largely due implantation standard World Health Organization-oral rehydration solution (WHO-ORS). However, use ORS been limited by its inability reduce fecal volume or duration....
ABSTRACT Background Ageing often affects biomarker production. Yet, clinical/optimal thresholds to guide clinical decisions do not consider this. Serum albumin decreases with age, but hypoalbuminaemia is defined as serum &lt;4.0 g/dl. This study explores whether age might affect levels and its association mortality in haemodialysis patients. Methods COSMOS (Current Management of Secondary Hyperparathyroidism: a Multicentre Observational Study) prospective, open-cohort, observational...
<b><i>Background:</i></b> Procalcitonin (PCT) may be a more sensitive marker for neonatal bacterial infections than C-reactive protein (CRP). However, the reference intervals of serum PCT were not sufficiently studied in neonates older 1 week age, especially very low birth weight infants. <b><i>Objectives:</i></b> This study investigated level according to gestational age (GA) and postnatal (PNA). <b><i>Methods:</i></b>...
Purpose: Human milk (HM) proteins are known as important factors in growing and development of neonates. For longer easier storage HM, freeze-drying is suggested one the promising methods for HM banks. However, effects on were not evaluated yet. The purpose this study to analyze compare proteomic data before after freeze-drying.Material methods: Totally nine fresh samples collected from three healthy mothers at 15 60 days lactation period. freeze-dried analysis was performed by shotgun...
Previous studies have suggested that insulin-like growth factor-1 (IGF-1) signaling might play an important role in renal fibrosis and regulation of the proliferation mesangial cells podocytes. We conducted present study to investigate association between single nucleotide polymorphisms (SNPs) IGF-1 receptor (IGF-1R) genes childhood immunoglobulin (Ig) A nephropathy (IgAN). analyzed five SNPs IGF-1R 188 pediatric IgAN patients 263 healthy controls. compared variations several sets subgroups...
An abnormal T-cell response is involved in the pathogenesis of various renal diseases. Survival naïve T cells dependent on interleukin 7 (IL7) and its receptor (IL7R). Thus, we investigated association between IL7R single nucleotide polymorphisms (SNPs) childhood IgA nephropathy (IgAN). We analyzed genotypic distributions two missense SNPs IL7R, rs1494558 (Ile66Thr) rs1494555 (Val138Ile), among 198 pediatric IgAN patients 288 healthy controls. Haplotype analysis measurement pair-wise linkage...
In this study, Liquid Chromatography-Mass Spectrometry (LC-MS)-based metabolomics profiling was conducted to elucidate the urinary profiles of premature infants during early and late postnatal stages. As a result, we discovered significant excretion maternal drugs in early-stage identified crucial metabolites like hormones amino acids. These findings shed light on impact neonatal metabolism underscore beneficial effects breastfeeding essential acids infants. This research not only enhances...
Human breastmilk is an invaluable nutritional and pharmacological resource with a highly diverse metabolite profile, which can directly affect the metabolism of infants. Application metabolomics discriminate complex relationship between such nutrients infant health. As most common biological fluid in metabolomic study, urinary may provide physiological impacts different resources, namely human formulated milk. In this we aimed to identify possible differences urine metabolome 30 infants...
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming factor β (TGFB) superfamily and important in both preservation of kidney function resistance injury. BMP2 is highly regulated kidney, high affinity binding sites for have been identified epithelial cells. has demonstrated play various roles pathogenesis renal diseases. However, role gene glomerulonephritis not previously investigated. We aimed evaluate association polymorphisms with...
Transient tachypnea of the newborn (TTN) is a benign disorder with variable clinical course that often leads to hospitalization. The aim this study was assess and validate relationship between serum cystatin C level symptom duration in infants TTN.Forty newborns presenting TTN who had undergone (Cys C) tests on first day admission Kyung Hee University Hospital (Seoul, Korea) from 2009 2013 were included. Cys level, creatinine (Cr) estimated glomerular filtration rate (eGFR), correlated...
Many studies have suggested that CXCL8 and CXCR2 play an important role in the pathogenesis of several types renal diseases. However, there is no prior study on association between polymorphisms these genes IgA nephropathy (IgAN), especially children. The genotyping data from 192 patients with childhood IgAN 397 controls showed significant differences frequencies gene rs2227306 (dominant, P = 0.019; overdominant, 0.009), rs2227543 0.01; 0.0057), rs4073 (codominant, 0.034; dominant, 0.011;...
To evaluate the significance of serum cystatin C (Cys C) levels in pediatric patients with chronic kidney disease (CKD) diagnosed by renal biopsy and who show normal creatinine (Cr) levels. The patient group was composed 167 males (M) 119 females (F) CKD enrolled from Department Pediatrics at Kyung Hee Medical Center July 2009 to May 2010. Cys C, Cr, C-reactive protein (CRP) were tested using a chemical analyzer (Toshiba, Nasushiobara, Japan). mean age total 11.72 years, body weight 32.24...
Although the benefits of breastfeeding are broadly acknowledged with efforts government and several medical societies, rate exclusive through 6 months is lower in Korea than developed countries.This study aimed to investigate pediatricians' perceptions barriers current counseling environment propose policies encourage Korea.Fourteen survey questions were during meetings Korean Society Breastfeeding Medicine experts. The Pediatric emailed a structured questionnaire domestic pediatricians...