A5012828193- Pediatric Urology and Nephrology Studies
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Ion Transport and Channel Regulation
- Urinary Bladder and Prostate Research
- Electrolyte and hormonal disorders
- Asthma and respiratory diseases
- Diabetes and associated disorders
- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Urinary Tract Infections Management
- Growth Hormone and Insulin-like Growth Factors
- Pelvic floor disorders treatments
- Urticaria and Related Conditions
- Pancreatic function and diabetes
- Urological Disorders and Treatments
- COVID-19 Clinical Research Studies
- Mast cells and histamine
- Prostate Cancer Diagnosis and Treatment
- Cocoa and Sweet Potato Agronomy
- Cardiovascular Conditions and Treatments
- Advances in Cucurbitaceae Research
- Congenital Heart Disease Studies
- Diabetes Management and Research
- Potassium and Related Disorders
Chonnam National University Hospital
2015-2024
Seoul Medical Center
2023-2024
Ajou University
2008-2024
Chonnam National University
2010-2023
Weatherford College
2021
University Health Care System
2021
Marymount University
2021
Chonnam National University Hwasun Hospital
2010-2020
Gwangju University
2017-2018
Ajou University Hospital
2016
Background/Aims: Role of autophagy in neutrophil function and the association related (ATG) gene polymorphisms with asthma susceptibility were suggested. In this study, we investigated genetic ATG5 ATG7 risk, severity neutrophilic airway inflammation. Methods: We recruited 408 patients 201 healthy controls. Sputum counts determined by H&E staining. Serum interleukin 8 (IL-8) levels measured enzyme-linked immunosorbent assay (ELISA). Genetic (–769T>C, –335G>A, 8830C>T) (–100A>G 25108G>C)...
To understand the genetics of steroid-sensitive nephrotic syndrome (SSNS), we conducted a genome-wide association study in 987 childhood SSNS patients and 3,206 healthy controls with Japanese ancestry. Beyond known associations HLA-DR/DQ region, common variants NPHS1-KIRREL2 (rs56117924, P=4.94E-20, odds ratio (OR) =1.90) TNFSF15 (rs6478109, P=2.54E-8, OR=0.72) regions achieved significance were replicated Korean, South Asian African populations. Trans-ethnic meta-analyses including...
Gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard to identify central precocious puberty (CPP). This requires multiple blood samples at different time points measure gonadotropin levels, and therefore expensive, time-consuming, uncomfortable for patients. We aimed simplify GnRH require fewer samples.A study of 166 girls with was undertaken. Blood were obtained 0, 15, 30, 45, 60, 90, 120 min after administration, levels luteinizing (LH) follicle-stimulating (FSH)...
Treatment with gonadotropin-releasing hormone (GnRH) agonist is the treatment of choice for central precocious puberty (CPP).Many previous studies concerning auxological effects GnRH in CPP have focused on final height.Much less attention has been paid to changes body weight.However, concerns expressed that may be associated increased mass index (BMI) both at initial presentation and during treatment.We retrospectively reviewed height BMI 38 girls CPP.All patients were treated over 18...
Increased FcεR1α expression with upregulated CD203c on peripheral basophils is seen in patients chronic urticaria (CU).However, there has been no published report the association between level and clinical disease activity CU patients.To investigate whether increase of basophil activation associated CU, we measured using a tricolor flow cytometric method 82 21 normal controls.The relationship percentage CD203c-expressing parameters was analyzed.The mean significantly higher than healthy...
Urinary tract infection (UTI) caused by resistant strains of bacteria is increasingly prevalent in children. The aim this study was to investigate the clinical characteristics and risk factors for UTI community-acquired extended-spectrum β-lactamase (CA-ESBL)-producing infants. This a retrospective performed over 5 years single Korean center. Hospitalized infants with febrile were enrolled divided into two groups (CA-ESBL vs. CA non-ESBL UTI). yearly prevalence calculated. Baseline course...
Henoch-Schönlein purpura is a systemic vasculitis that mainly occurs in children. Renal impairment major complication of purpura, but there no established predictive marker for renal involvement. Thus, this study, we investigated the risk factors involvement children with purpura.The medical records newly diagnosed as having between 2005 and 2020 were reviewed retrospectively. Selected laboratory data recorded before treatment initiation. The date age at diagnosis; sex; presence arthralgia,...
Recent hypertension guidelines have recommended lower blood pressure (BP) targets in high-risk patients. However, there are no specific based on age or systolic and diastolic (SBP DBP, respectively). We aimed to assess the effects of age-related BP development end-stage renal disease (ESRD) patients with diabetes.A total 2 563 870 diabetes aged >20 years were selected from Korean National Health Screening Program 2009 2012 followed up until end 2019. Participants categorized into groups,...
Despite the risk of incident chronic kidney disease among patients with rheumatoid arthritis (RA), association RA and end-stage renal (ESRD) has not been clearly elucidated. We aimed to investigate ESRD.A total 929,982 subjects (n = 154,997) or without 774,985) from National Health Insurance Service (NHIS) database in Koreas (corresponding period between 2009 2017) were retrospectively analyzed. was defined by International Classification Diseases, 10th Revision, Clinical Modification...
Sensitization to staphylococcal superantigens (SAgs) could contribute asthma severity. However, its relevance with eosinophilic phenotype has not yet been clarified. This study aimed investigate associations between serum specific IgE levels SAg and airway inflammation in adult asthmatics.
Henoch-Schönlein purpura (HSP) is a common form of vasculitis in children. It typically involves small vessels the skin, gastrointestinal (GI) tract, joints, and kidneys. GI involvement most severe short-term complication bleeding major HSP, but there no established predictive marker bleeding. Blood neutrophil-to-lymphocyte ratio (NLR) has been proposed as potentially useful clinical outcome diseases with an inflammatory component. The aim this study was to clarify association NLR HSP...
There are few published reports concerning the efficacy of oral ibuprofen for treatment patent ductus arteriosus (PDA) in extremely low birth weight (ELBW) infants. Oral was compared to intravenous indomethacin regarding and safety PDA infants weighting less than 1,000 g at birth. This a retrospective study single center. Data on ELBW who had an echocardiographically confirmed were collected. The treated with either or ibuprofen. Rate ductal closure, need additional treatment, drug-related...
Adequate fluid management is an important therapeutic goal of dialysis.Recently, bioelectrical impedance methods have been used to determine body status, but pediatric reports are rare.To the accuracy in assessment statusof children undergoing hemodialysis (HD), 12 on HD were studied.A multi-frequency bioimpedance analysis device (Inbody S10) and spectroscopy (BCM) evaluate status.Fluid removal during a session (assessed as body-weight change, ΔBWt) was compared with difference total water...
Abstract The genotype–phenotype correlation of the X-linked Alport syndrome (XLAS) has been well elucidated in males, whereas it remains unclear females. In this multicenter retrospective study, we analyzed 216 Korean patients (male:female = 130:86) with XLAS between 2000 and 2021. were divided into three groups according to their genotypes: non-truncating group, abnormal splicing truncating group. male patients, approximately 60% developed kidney failure at median age 25.0 years, survival...
ABSTRACT. Cryptococcus neoformans infections occur most frequently in immunocompromised patients. Here, we report a case of cryptococcal meningitis previously immunocompetent 78-year-old female patient after treatment COVID-19. Underlying diseases included hypertension, hyperlipidemia, and diabetes. The was critically ill treated with remdesivir, baricitinib, dexamethasone. During hospitalization, her mental state changed, C. detected the cerebrospinal fluid. She died despite receiving...
Hypertension is one of the most important complications chronic kidney disease (CKD) as it exacerbates progression in children. The aim this study to identify characteristics and factors associated with hypertension children CKD.
Background: Hypercalciuria is one of the most common causes unexplained isolated hematuria.The diagnostic methods for hypercalciuria have not yet been standardized.The aim this study was to assess whether random urinary calcium/creatinine ratio could be used as a screening tool in children with hematuria.Methods: This prospective included 264 primary hematuria whom both and 24 hr evaluations were performed.Pearson correlation ROC curve correlations.A multiple linear regression model analyze...
Growth hormone deficiency (GHD) is defined as a serum peak GH concentration <10 ng/mL with provocation tested by combination of at least two separate tests. The aim this study was to compare standard tests, insulin and levodopa (L-dopa), primary focus on specificity accuracy. Clinical data were collected retrospectively from review 120 children who visited the pediatric endocrine clinic Chonnam National University Hospital for evaluation short stature between January 2006 April 2014....
Congenital Syphilis Presenting with Only Nephrotic Syndrome: Reemergence of a Forgotten DiseaseSyphilis infection has re-emerged after years declining incidence.The prevalence congenital syphilis (CS) increased in Korea and other countries during the last few decades.Untreated infants develop symptoms such as rhinorrhea, anemia, jaundice, cutaneous lesions, hepatosplenomegaly, pseudoparalysis within weeks or months.Significant renal disease is uncommon CS, clinical involvement varies from...
Information on the effectiveness of nirmatrelvir/ritonavir against omicron is limited. The clinical response and viral kinetics to therapy in real world need be evaluated.Mild moderate coronavirus disease 2019 (COVID-19) patients with risk factors for severe illness were prospectively enrolled as a treatment group versus control supportive care. Serial load culture from upper respiratory tract evaluated seven days, responses adverse reactions 28 days.A total 51 analyzed including 40 11...
Purpose: This study aims to determine the efficacy and safety of house dust mite (HDM)sublingual immunotherapy (SLIT) in elderly patients with AR.Methods: A total 45 aged ≥ 60 years HDM-induced AR who had 3 A/H ratio on skin prick test and/or 0.35 IU/L both Dermatophagoides farinae pteronyssinus by ImmunoCAP were enrolled 4 university hospitals.To evaluate additional effects HDM-SLIT, they randomized SLIT-treated group (n = 30) or control 15).Rhinoconjunctivitis symptom score (RTSS),...
Purpose This study aim to investigate the occurrence of autoimmune thyroid disease in children and adolescents at onset type 1 diabetes mellitus (T1DM) assess whether presence diabetes-specific autoantibodies can predict disorder. Methods Seventy-three with T1DM were recruited. Glutamic acid decarboxylase antibodies (GADA), islet cell (ICA), insulin (IAA), determined all patients time diagnosis. Results The majority (87.7%) had least one pancreatic antibody (74.0% for GADA, 20.5% ICA, 24.7%...