A5048461743- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Growth Hormone and Insulin-like Growth Factors
- Pediatric Urology and Nephrology Studies
- Chronic Kidney Disease and Diabetes
- Infectious Encephalopathies and Encephalitis
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Metabolism, Diabetes, and Cancer
- Streptococcal Infections and Treatments
- Birth, Development, and Health
- Dialysis and Renal Disease Management
- Apelin-related biomedical research
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pancreatic function and diabetes
- Vascular anomalies and interventions
- Diabetes and associated disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dermatological and COVID-19 studies
- RNA modifications and cancer
- Adenosine and Purinergic Signaling
- Chronic Lymphocytic Leukemia Research
- Platelet Disorders and Treatments
University of Yamanashi
2009-2025
National Hospital Organization Kochi National Hospital
2023-2025
Suwa Red Cross Hospital
2024
University of Yamanashi Hospital
1997-2023
Kobe University
2020
Kitasato University
2020
Tohoku Medical Megabank Organization
2020
Tohoku University
2020
Hoshi University
2020
Jeju National University
2020
Background Nephrotic syndrome is the most common cause of chronic glomerular disease in children. Most these patients develop steroid-sensitive nephrotic (SSNS), but loci conferring susceptibility to childhood SSNS are mainly unknown. Methods We conducted a genome-wide association study (GWAS) Japanese population; 224 with and 419 adult healthy controls were genotyped using Affymetrix Japonica Array discovery stage. Imputation for six HLA genes ( HLA-A , -C, -B -DRB1 -DQB1 -DPB1 ) was on...
Background X-linked Alport syndrome (XLAS) is a progressive hereditary nephropathy caused by mutations in the COL4A5 gene. Genotype-phenotype correlation male XLAS relatively well established; relative to truncating mutations, nontruncating exhibit milder phenotypes. However, transcript comparison between cases with splicing abnormalities that result premature stop codon and those has not been reported, mainly because analysis routinely conducted patients XLAS. Methods We examined expression...
To understand the genetics of steroid-sensitive nephrotic syndrome (SSNS), we conducted a genome-wide association study in 987 childhood SSNS patients and 3,206 healthy controls with Japanese ancestry. Beyond known associations HLA-DR/DQ region, common variants NPHS1-KIRREL2 (rs56117924, P=4.94E-20, odds ratio (OR) =1.90) TNFSF15 (rs6478109, P=2.54E-8, OR=0.72) regions achieved significance were replicated Korean, South Asian African populations. Trans-ethnic meta-analyses including...
We herein report the case of a 12-year-old boy with dense deposit disease (DDD) evoked by streptococcal infection. He had been diagnosed to have asymptomatic hematuria syndrome at age 6 during school screening. At 12 years age, he was found macrohematuria and overt proteinuria hypocomplementemia 2 months after pharyngitis. Renal biopsy showed endocapillary proliferative glomerulonephritis double contours glomerular basement membrane. Hypocomplementemia were sustained for over 8 weeks....
<i>Background:</i> There is no clear consensus as to which patients with Henoch-Schönlein purpura nephritis (HSPN) at risk of a poor outcome should be treated and what therapeutic regimen used. <i>Methods:</i> Nine children heavy proteinuric HSPN received prompt initiation methylprednisolone pulse therapy (MPT) combined tonsillectomy in prospective study. <i>Results:</i> At presentation, the mean values for patients’ urine protein excretion (early-morning...
OBJECTIVE To clarify the involvement of IGF binding protein (IGFBP)-1 in dawn rise plasma glucose and overall glycemic control patients with IDDM. RESEARCH DESIGN AND METHODS Seventy IDDM were divided into three groups according to pubertal development. Blood samples obtained for measuring glucose, IGFBP-1, free insulin at 2200, 0500, 0700 over a 2-day period. Levels HbA1c, IGF-1, IGFBP-3 determined 0700. Urinary growth hormone (GH) was collected overnight. examine its frequency, phenomenon...
Post-streptococcal glomerulonephritis (PSGN) generally has a good renal prognosis, and immunosuppressive therapies are not needed. However, few patients present with severe acute kidney injury extensive crescent formations. The etiology of such is well known, involvement anti-neutrophil cytoplasmic antibodies rarely reported. A 9-year-old girl rapidly progressive nephritic syndrome was diagnosed PSGN. biopsy showed diffuse crescentic immunoglobulin G C3 deposits; moreover, humps were...
We attempted to clarify the association between angiotensin-converting enzyme (ACE) gene polymorphism and other predictive factors for macroangiopathy in children adolescents with uncomplicated insulin-dependent diabetes mellitus (IDDM). Sixty-three patients were divided into 3 groups according ACE genotypes. The lipid profiles evaluated level of lipoprotein(a) (Lp(a)) II genotype was significantly lower than that D allele. Lp(a) correlated apo B/apo A-I (p < 0.001, r = 0.63) atherogenic...
Although epidemiological surveys of paediatric rheumatic diseases in Japan have been conducted, they were single with no continuity. This is the first report Pediatric Rheumatology Association registry database, which was established to continuously collect data for diseases.Pediatric International Collaborate Unit Registry version 2 (PRICUREv2) a database by Japan. The analysed age onset, time diagnosis, sex differences, seasonality, and other factors.Our showed same trend regarding rates...
Progressive kidney dysfunction is often observed in children with bilateral hypoplastic kidneys. While glomerulopathy can exacerbate progression, only IgA nephropathy and post-streptococcal acute glomerulonephritis have been noted such cases. Herein, we present a case of four-year-old female patient kidney, dysfunction, significant proteinuria (urinary protein/creatinine ratio > 1 g/gCr), prompting referral owing to persistent hematuria since two years age. Enalapril was initiated; however,...
Henoch-Schönlein purpura (HSP) is a common self-limited vasculitis in children. The long-term prognosis depends on renal involvement. In severe nephritis (HSPN) patients, >50 % have crescent formation and nephrotic syndrome that are important predicted outcomes. Therefore, for such an aggressive immunosuppressive therapy needed to prevent the progression. However, there no consensus appropriate therapeutic regimen pediatric HSPN patients. this paper, we reported 6-year-old boy who presented...
Azathioprine is widely used as a steroid-sparing agent for autoimmune disease or renal disease. Pure red blood cell aplasia has been considered to be rare, but direct adverse effect of azathioprine. We describe 12-year-old girl who developed pure during azathioprine therapy which might have induced by occult and persistent parvovirus B19 infection. Case report. First admission. A (140 cm, 30 kg) was admitted our hospital because spiking fever, myalgia, muscle weakness, joint swelling mild...
Immunoglobulin A (IgA) nephropathy shows great variability regarding the histological features of lesions human renal glomeruli. In present study, quick-freezing and deep-etching (QF-DE) method was used to analyze glomerular ultrastructure biopsied kidney tissues from children with IgA nephropathy. Biopsied were routinely prepared for light microscopy, immunofluorescence conventional electron replica microscopy. The three-dimensional glomeruli clearly observed by using QF-DE method. Three...
It has been hypothesized that a decreased amount of the free form insulin-like growth factor-I (fIGF-I) results in morning hyperglycemia patients with type 1 diabetes mellitus. In this study, we attempted to clarify role fIGF-I relation total IGF-I (tIGF-I) and its related peptides or proteins diabetes. Forty-seven diabetes, mean age 13.7 years, were evaluated. Blood samples obtained for measurement BG at 0200, 0400 0700, insulin, (tIGF-I), fIGF-I, IGFBP-1 IGFBP-3 0700. The SD scores (SDS)...
Abstract Background The aim of this study was to assess the diagnostic value urinary fibrin/fibrinogen degradation products ( uFDP ) measured using an anti‐fibrinogen antibody in patients with orthostatic proteinuria OP ), and their use differentiating between glomerulonephritis GN ). Methods were first urine morning (supine) non‐first during a hospital visit (upright) then normalized creatinine /Cr, ng/mgCr). We compared (i) n = 16); (ii) those remission from nephrotic syndrome NS , 14)...
High GH and low IGF-I are well known in IDDM patients. To delineate this altered GH-IGF-I axis IDDM, we investigate the role of GH-binding protein (GHBP) relation to metabolic nutritional states.Forty seven patients with mean 13.7 years, were evaluated. Blood samples obtained before insulin injection breakfast test for plasma glucose (PG), IGF-I, IGFBP-1, IGFBP-3, total complex GHBP (tGHBP cGHBP), HbA1c. Urine collected morning urinary (uGH). The difference between tGHBP cGHBP is defined as...