A5084675851- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Pediatric Urology and Nephrology Studies
- Platelet Disorders and Treatments
- Autoimmune Bullous Skin Diseases
- Renal and related cancers
- Neurological Complications and Syndromes
- Pregnancy and Medication Impact
- Vasculitis and related conditions
- Pharmacological Effects and Toxicity Studies
- Tuberous Sclerosis Complex Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Lupus Erythematosus Research
- Renal Transplantation Outcomes and Treatments
- Childhood Cancer Survivors' Quality of Life
- Urological Disorders and Treatments
- Complement system in diseases
- Central Venous Catheters and Hemodialysis
- Neonatal Health and Biochemistry
- Immunodeficiency and Autoimmune Disorders
- Electrolyte and hormonal disorders
- Adolescent and Pediatric Healthcare
- Renal and Vascular Pathologies
Kitasato University
2019-2025
Tokyo Metropolitan Children's Medical Center
2014-2024
Hyogo University of Teacher Education
2024
National Center For Child Health and Development
2015-2023
RELX Group (United States)
2023
Kitasato University Hospital
2020-2022
Matsudo City Hospital
2006-2020
Tokushima Hospital
2020
Kobe University
2020
Toho University
2020
In this multicenter, open-label, randomized controlled trial, we determined whether 2-month prednisolone therapy for steroid-sensitive nephrotic syndrome was inferior or not to 6-month despite significantly less steroid exposure. The primary end point time from start of initial treatment frequently relapsing syndrome. pre-specified non-inferiority margin a hazard ratio 1.3 with one-sided significance 5%. We randomly assigned 255 children an episode either 2 - which 246 were eligible final...
Significance Statement Children with frequently relapsing, steroid-dependent nephrotic syndrome (FRSDNS) often require multiple courses of rituximab. However, long-term effects from repeated treatments remain unknown. In this international, multicenter study 346 children receiving 1149 rituximab, the risk relapse decreased and relapse-free survival significantly improved treatments. Important side effects, including hypogammaglobulinemia, neutropenia, infections, were mostly mild, but...
Background Nephrotic syndrome is the most common cause of chronic glomerular disease in children. Most these patients develop steroid-sensitive nephrotic (SSNS), but loci conferring susceptibility to childhood SSNS are mainly unknown. Methods We conducted a genome-wide association study (GWAS) Japanese population; 224 with and 419 adult healthy controls were genotyped using Affymetrix Japonica Array discovery stage. Imputation for six HLA genes ( HLA-A , -C, -B -DRB1 -DQB1 -DPB1 ) was on...
Significance Statement Rituximab is the standard therapy for childhood-onset complicated frequently relapsing or steroid-dependent nephrotic syndrome (FRNS/SDNS). However, most patients redevelop FRNS/SDNS after peripheral B cell recovery. This multicenter, randomized, double-blind, placebo-controlled trial was conducted to examine whether mycophenolate mofetil (MMF) administration rituximab can prevent treatment failure (FRNS, SDNS, steroid resistance, use of immunosuppressive agents...
We investigated the expression of ERK, p38 mitogen-activated protein kinase (p38), and JNK in renal tubules diabetic rats following 3 wk after streptozotocin injection (DM). Although ERK was not different between controls DM, phosphorylated expressed more intensely DM. And were detected only kidney localized all tubular segments. similarly Transforming growth factor (TGF)-β segments coinciding with localization p38. In LLC-PK 1 cells, phosphorylation increased 24- to 72-h exposure high...
Abstract. Various growth factors and vasoactive substances are implicated in the pathogenesis of renal seen early diabetes mellitus (DM). Mitogen-activated protein kinase (MAPK) is an important mediator these extracellular stimuli. Protein C (PKC), enzyme known to be stimulated DM, also activates MAPK. Thus, MAPK activity was examined glomeruli from streptozotocin-induced DM rats. activity, measured as myelin basic kinase, elevated by approximately 50% versus controls (CON). Increased...
Chronic kidney disease (CKD) in children is a progressive and intractable condition that may severely impair the child's growth, development quality of life. Epidemiological information on pediatric CKD, particularly Asians, scant.We conducted nationwide, population-based survey Japanese aged 3 months to 15 years with pre-dialysis CKD examine prevalence Japan. was classified according newly established criteria derived from reference serum creatinine levels children. Surveys were sent 1190...
Summary Background and objectives Early identification of frequently relapsing children with idiopathic nephrotic syndrome is desirable. Design, setting, participants, & measurements The relapse status clinical data patients previously registered (January 1993 to December 2001) in a multicenter prospective study the International Study Kidney Disease Children regimen were analyzed for risk frequent relapsers over 2-year follow-up period. Results Of 166 (113 boys 53 girls; median age=5.1...
Although numerous epidemiological surveys performed across several continents and ethnic groups have linked low birth weight (LBW) to increased risk of chronic kidney disease (CKD) in adulthood, the effects prematurity on development CKD childhood not been clearly established. Data sex, LBW incidence gestational age were compared between paediatric cases a control group. Paediatric obtained from nationwide survey conducted by Pediatric Study Group Japan. The population attributable fraction...
To understand the genetics of steroid-sensitive nephrotic syndrome (SSNS), we conducted a genome-wide association study in 987 childhood SSNS patients and 3,206 healthy controls with Japanese ancestry. Beyond known associations HLA-DR/DQ region, common variants NPHS1-KIRREL2 (rs56117924, P=4.94E-20, odds ratio (OR) =1.90) TNFSF15 (rs6478109, P=2.54E-8, OR=0.72) regions achieved significance were replicated Korean, South Asian African populations. Trans-ethnic meta-analyses including...