A5028360065- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Pediatric Urology and Nephrology Studies
- Renal and Vascular Pathologies
- Chronic Kidney Disease and Diabetes
- Neurological Complications and Syndromes
- Organ Donation and Transplantation
- Renal and related cancers
- Organ Transplantation Techniques and Outcomes
- Pharmacological Effects and Toxicity Studies
- Cytomegalovirus and herpesvirus research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Moyamoya disease diagnosis and treatment
- Polyomavirus and related diseases
- Tuberous Sclerosis Complex Research
- Autoimmune Bullous Skin Diseases
- Urological Disorders and Treatments
- Blood groups and transfusion
- Electrolyte and hormonal disorders
- Platelet Disorders and Treatments
- Pregnancy and Medication Impact
- Systemic Lupus Erythematosus Research
- Neonatal Health and Biochemistry
- Transplantation: Methods and Outcomes
Toho University
2016-2025
Tokyo Metropolitan Children's Medical Center
2010-2024
National Hospital Organization
2024
Okayama Medical Center
2024
National Defense Academy of Japan
2023
Gakushuin University
2023
Wakayama Medical University
2020
Matsudo City Hospital
2020
Kobe University
2020
Kurashiki Central Hospital
2020
Possible roles of anti-nephrin antibodies in post-transplant recurrent focal segmental glomerulosclerosis (FSGS) have been reported recently. To confirm these preliminary results, we performed a multi-institutional study 22 Japanese pediatric kidney transplant recipients with FSGS including eight genetic and 14 non-genetic (presumed primary) FSGS. Eleven the patients had Median (interquartile range) plasma levels measured using ELISA were markedly high at 899 (831, 1292) U/mL (cutoff 231...
Chronic kidney disease (CKD) in children is a progressive and intractable condition that may severely impair the child's growth, development quality of life. Epidemiological information on pediatric CKD, particularly Asians, scant.We conducted nationwide, population-based survey Japanese aged 3 months to 15 years with pre-dialysis CKD examine prevalence Japan. was classified according newly established criteria derived from reference serum creatinine levels children. Surveys were sent 1190...
Although numerous epidemiological surveys performed across several continents and ethnic groups have linked low birth weight (LBW) to increased risk of chronic kidney disease (CKD) in adulthood, the effects prematurity on development CKD childhood not been clearly established. Data sex, LBW incidence gestational age were compared between paediatric cases a control group. Paediatric obtained from nationwide survey conducted by Pediatric Study Group Japan. The population attributable fraction...
To understand the genetics of steroid-sensitive nephrotic syndrome (SSNS), we conducted a genome-wide association study in 987 childhood SSNS patients and 3,206 healthy controls with Japanese ancestry. Beyond known associations HLA-DR/DQ region, common variants NPHS1-KIRREL2 (rs56117924, P=4.94E-20, odds ratio (OR) =1.90) TNFSF15 (rs6478109, P=2.54E-8, OR=0.72) regions achieved significance were replicated Korean, South Asian African populations. Trans-ethnic meta-analyses including...
Abstract Background Vesicoureteral reflux (VUR) after pediatric kidney transplantation (KT) is a frequent urologic complication. Endoscopic Deflux ® injection treatment option. However, ureteral obstruction potential complication that may have serious outcomes for patients who undergone KT. We report case of acute injury (AKI) caused by with foreign body reaction immediately VUR transplantation. Case presentation encountered 5-year-old boy underwent living-donor KT at age 4 years because...
Posterior reversible encephalopathy syndrome (PRES) is a distinctive and potentially serious complication of the nephrotic syndrome. The objective present study to characterize factors predisposing development PRES in paediatric patients with syndrome.We investigated idiopathic who developed between 1999 2005 our institution. Patients steroid-sensitive those steroid-resistant that were proven be eligible.In total, seven ranging age from 1.5 15.1 years old analysed. At onset PRES, six state....
Abstract Although vaccination may precipitate relapses of nephrotic syndrome (NS) in children with idiopathic NS, no data are available regarding NS activity influenza (flu) virus infections and after receiving inactivated flu vaccines. We conducted a nationwide study aged 6 months to 15 years assess the relationship between relapse, vaccination, infections. used multivariate Poisson regression model (MPRM) calculate risk ratio (RR) for infection relapse without vaccination. Data 306 were...
The risk of progressing to end-stage kidney disease (ESKD) and factors associated with progression in children chronic (CKD) are unclear, especially Asian children.We started a nationwide, prospective cohort study 447 Japanese pre-dialysis CKD 2010, follow-up 2011. Progression ESKD was analyzed by Kaplan-Meier analysis according stage. Cox regression used identify for progression.Data were 429/447 children. Five patients died, which four died before ESKD. Fifty-two progressed (median 1.49...
Abstract Background Recurrence of focal segmental glomerulosclerosis ( FSGS ) in pediatric kidney allografts is associated with poor graft survival. Several therapeutic regimens have been proposed, conflicting results. Methods Ten patients recurrent after transplantation were treated a protocol methylprednisolone MP infusions combination cyclosporine C s A )‐based immunosuppression. The received drug regimen 20 mg/kg on three consecutive days at week 1, 3, and 5, then monthly until six...
Proteinuria is the most important risk factor for IgA nephropathy progression. The purpose of this study to evaluate long-term outcome and factors poor prognosis in childhood nephropathy.Patients who were diagnosed with between 1972 1992 at Tokyo Metropolitan Kiyose Children's Hospital included. We analyzed progression end-stage kidney disease (ESKD) chronic renal insufficiency (CRI) using Kaplan-Meier method multivariate analyses Cox proportional hazard model.One hundred patients included...
Abstract Background Information on the epidemiology of idiopathic nephrotic syndrome (INS) in children, complications INS and side effects steroid therapy is scarce. Methods The Japanese Pediatric Survey Holding Nephrotic Syndrome, a nationwide cohort study, was conducted by Study Group Renal Disease Children enrolled 2099 children with newly diagnosed between 1 January 2010 31 December 2012. We follow-up study during first onset patients’ prognosis this cohort. Results obtained data 999...
C3 glomerulonephritis (C3GN) is a recently described disease that related to membranoproliferative (MPGN). We retrospectively compared the frequencies, clinical characteristics, treatment modalities, and outcomes of C3GN MPGN in cohort Japanese children.Children who were pathologically diagnosed with (type I or III) our hospital divided into two groups based on immunofluorescence imaging renal biopsies: children induced by classical complement pathway activation (classical MPGN) C3GN.Of 14...