A5018887200- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Organ Donation and Transplantation
- Neurological Complications and Syndromes
- Pharmacological Effects and Toxicity Studies
- Pregnancy and Medication Impact
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Renal and related cancers
- Dialysis and Renal Disease Management
- Ureteral procedures and complications
- Polyomavirus and related diseases
- Renal cell carcinoma treatment
- Xenotransplantation and immune response
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Central Venous Catheters and Hemodialysis
- Complement system in diseases
- Viral-associated cancers and disorders
- Urologic and reproductive health conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
Committee on Publication Ethics
2024
Weatherford College
2024
Toho University
2014-2023
Toho University Omori Medical Center
2011-2019
Pediatric Nephrology of Alabama
2014
Tokyo Women's Medical University
2006-2011
Kobe University
2011
Hokkaido University
2011
National Center For Child Health and Development
2011
Boston Children's Hospital
2000-2008
Abstract Mutations in the gene coding for hepatocyte nuclear factor-1β (HNF-1β) have been known to cause a form of maturity-onset diabetes young (MODY5), which is usually characterized by dominantly inherited adolescence-onset mellitus associated with renal cysts. This report, however, describes recurrence novel missense mutation HNF-1β gene, S148W (C443G), two sibs, one neonatal and other polycystic, dysplastic kidneys leading early failure. The former patient had only few small cysts...
To evaluate the nature of human cellular immune response to porcine xenoantigens, cytolytic T lymphocyte (CTL) cell lines were generated against aortic endothelial cells (PAEC). After four stimulations, phenotypes primarily CD8+ (79.7±19.6%). Natural killer not detected. Functional analysis showed specific cytotoxicity syngeneic targets with no lysis unrelated cells, or K562, a natural target. The major histocompatibility complex (MHC) specificity this was confirmed when established PAEC...
Abstract Background Recurrence of focal segmental glomerulosclerosis ( FSGS ) in pediatric kidney allografts is associated with poor graft survival. Several therapeutic regimens have been proposed, conflicting results. Methods Ten patients recurrent after transplantation were treated a protocol methylprednisolone MP infusions combination cyclosporine C s A )‐based immunosuppression. The received drug regimen 20 mg/kg on three consecutive days at week 1, 3, and 5, then monthly until six...
Background Major symptoms of progressive chronic kidney disease (CKD) are similar to those hypothyroidism. Hidden hypothyroidism underlying CKD often observed in clinical practice. This study aimed ascertain the frequency complicated by CKD, and analyze factors impacting thyroid function.Methods During period from April 2012 through October 2016, 510 patients at our outpatient clinic were measured function for diagnosing (overt hypothyroidism, OH; subclinical SH; non-thyroidal illness, NTI)...
Objective: Tubularized incised plate urethroplasty has become a popular technique for repairing distal and proximal hypospadias in many institutions. Dorsal inlay graft been used our institution since 2003 to reduce the risk of meatal stenosis. In present study, we evaluated results dorsal procedure. Methods: A total 28 patients with no deep groove severe curvature underwent one‐stage using an inner preputial‐based graft. The medical records all were retrospectively reviewed regard...
Extensive data have been accumulated for adults who undergone ABO-incompatible (ABOi)-living kidney transplantation (LKT). In contrast, available published on pediatric recipients underwent ABOi-LKT from the early to middle 2000s is very limited. Thus, has remained relatively rare, and there a lack of large, multicenter data.We analyzed Japanese Kidney Transplant Registry clarify patient graft outcomes 2002 2015. A total 102 ABOi 788 ABO-compatible (ABOc) were identified in this study. All...
We analyzed the presentation, treatment and survival of 4 children with renal cell carcinoma.We retrospectively reviewed pathological hospital records Japanese diagnosed carcinoma at our from 1970 to 1998.In 1 boy 3 girls an average age 8 years 7 months diagnosis most common presenting complaints were gross hematuria in 75% a palpable abdominal mass 50%. Computerized tomography revealed characteristic calcification within tumor patients (75%). In remaining case lesion had high density areas...
RTx of adult-size kidneys presents a size mismatch in small pediatric recipients, and there are potential surgical complications. This study reveals the outcomes intra- extraperitoneal low-weight (less than 15 kg) recipients. We studied 51 patients weighing less kg who received living-related donor renal transplant between 2009 2017. The intraperitoneal (group A, n = 24) B, 27) approaches were compared. In group mean age, Ht, weight 3.8 ± 1.6 years, 83.7 6.5 cm, 10.5 1.8 kg; 5.0 1.9 95.3 7.3...
Background Children with a compromised inferior vena cava (IVC) were previously considered unsuitable for kidney transplantation because of the technical difficulties and increased risk graft thrombosis secondary to inadequate renal venous outflow. Methods We conducted retrospective study 11 transplants in 9 patients end-stage disease thrombosed IVCs who received adult allografts between 2000 2015. The mean age at was 7.5 ± 3.5 years. A pretransplant diagnosis IVC made 7 by magnetic...
Background. Human T-cell response against xenogeneic antigens may occur either by direct recognition of on antigen-presenting cells(APCs) or an indirect pathway mediated autologous APCs. Methods. The proliferative human CD4+ T cells to porcine aortic endothelial (PAECs) was measured. From these lines, eight clones were obtained limiting dilution. Results. cells, in the absence monocytes, proliferated PAECs only after swine leukocyte antigen (SLA) class II molecules induced PAECs....
Abstract WDR19 has been reported as a causative gene of nephronophthisis‐related ciliopathies. Patients with mutations can show various extrarenal manifestations such skeletal disorders, Caroli disease, and retinal dystrophy, typically display nephronophthisis renal phenotype. However, there is limited information on the phenotypes patients mutations. We report two Japanese infants Sensenbrenner syndrome caused by who demonstrated different features in ultrasound histopathological results,...
Objectives To evaluate long‐term outcomes and risk factors for graft loss in pediatric kidney transplantation over a 30‐year period. Methods We retrospectively assessed 400 consecutive transplants carried out 377 children during 1975–2009. Patients were stratified according to the immunosuppressive regimen (era 1: methylprednisolone azathioprine; era 2: calcineurin inhibitor‐based therapy, including azathioprine or mizoribine; 3: basiliximab induction inhibitors, mycophenolate mofetil)....
ABSTRACT Aim Epstein syndrome is a hereditary disease characterized by macrothrombocytopaenia and progressive nephritis. The abnormality of the MYH9 gene has strong relationship to severity disease. Severe progresses end‐stage renal rapidly after adolescence. There no established therapy. We sought clarify appropriate management nephropathy. Methods patients who underwent transplantation at our institution between March 2009 2017 were enrolled. was diagnosed based on clinical features...