A5031777010- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Child Nutrition and Water Access
- Global Maternal and Child Health
- Pediatric Urology and Nephrology Studies
- Iron Metabolism and Disorders
- Acute Kidney Injury Research
- Adolescent and Pediatric Healthcare
- Hemoglobinopathies and Related Disorders
- Vaccine Coverage and Hesitancy
- HIV-related health complications and treatments
- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Childhood Cancer Survivors' Quality of Life
- Pregnancy and Medication Impact
- Gastroesophageal reflux and treatments
- HIV/AIDS drug development and treatment
- Cerebrospinal fluid and hydrocephalus
- Bacterial Infections and Vaccines
- Pelvic floor disorders treatments
- Poverty, Education, and Child Welfare
- Systemic Lupus Erythematosus Research
- COVID-19 Clinical Research Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Lagos University Teaching Hospital
2015-2025
University of Lagos
2015-2024
Old Dominion University
2024
Eastern Virginia Medical School
2024
Institute for Health Metrics and Evaluation
2021-2023
University of Washington
2021-2023
Isfahan University of Medical Sciences
2023
University of Health and Allied Sciences
2023
Jimma University
2023
Philadelphia University
2023
Previous global analyses, with known underdiagnosis and single cause per death attribution systems, provide only a small insight into the suspected high population health effect of sickle cell disease. Completed as part Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2021, this study delivers comprehensive assessment prevalence disease mortality burden by age sex for 204 countries territories from 2000 to 2021.We estimated cause-specific using standardised GBD approaches, in which...
Background The modest decline in child mortality Africa raises the question whether pattern of diseases associated with acute kidney injury (AKI) children Nigeria has changed. Methods A database children, aged between one month and 16 years, AKI (using modified pediatric RIFLE criteria) was reviewed. cause defined as major underlying disease. clinical laboratory features who survived were compared to those died. Results Of 4 015 admitted into Lagos University Teaching Hospital July 2010...
Introduction: preterm birth is a dire complication of pregnancy that poses huge long-term medical and financial burdens for affected children, their families, the health care system. The aim present study was to identify characteristics associated with births at Lagos University Teaching Hospital (LUTH), Lagos, Nigeria from 2011 2013.
Cooking with dirty-burning fuels is associated health risk from household air pollution. We assessed the prevalence of and factors use cooking fuels, attitudes barriers towards liquefied petroleum gas (LPG). This was a cross-sectional, population-based survey conducted in 519 households Lagos, Nigeria. used structured questionnaire to obtain information regarding choice fuel LPG. Kerosene most frequently (n = 475, 91.5%; primary n 364, 70.1%) followed by charcoal 159, 30.6%; 88, 17%) LPG 86,...
To understand the genetics of steroid-sensitive nephrotic syndrome (SSNS), we conducted a genome-wide association study in 987 childhood SSNS patients and 3,206 healthy controls with Japanese ancestry. Beyond known associations HLA-DR/DQ region, common variants NPHS1-KIRREL2 (rs56117924, P=4.94E-20, odds ratio (OR) =1.90) TNFSF15 (rs6478109, P=2.54E-8, OR=0.72) regions achieved significance were replicated Korean, South Asian African populations. Trans-ethnic meta-analyses including...
<title>Abstract</title> <bold>Background</bold> Congenital malaria is a recognized cause of morbidity and mortality in newborns. Signs symptoms congenital are non-specific could be confused with Neonatal sepsis. There has been recent decline burden worldwide attributed to new strategy recommended by the WHO including use intermittent preventive treatment pregnancy using Sulfadoxine-Pyrimethamine (IPT-SP) during pregnancy, long lasting insecticide treated nets (LLINs), case management...
Congenital malaria is an important cause of morbidity and mortality in newborns. Signs symptoms congenital are non-specific could be confused with Neonatal sepsis. There has been a recent decline burden worldwide attributed to new strategy recommended by the WHO including use intermittent preventive treatment pregnancy using Sulfadoxine-Pyrimethamine (IPT-SP) during pregnancy, long lasting insecticide treated nets, case management Artemisinin-based combination therapy etc. This study sets...
Insufficient data to guide the authorities responsible for resource allocation and a focus on communicable diseases increase challenges of care children with kidney disease in resource-constrained settings like ours. This study was performed aim describe current spectrum pediatric nephrology tertiary hospital Sub-Saharan Africa highlight encountered their care. A 4-year retrospective review renal admissions carried out overall prevalence, disease-specific prevalence mortality rates were...
Introduction International professional groups are supporting the training of physicians in developing countries nephrology, including peritoneal dialysis (PD). This report documents impact such efforts provision manual PD for children with acute kidney injury (AKI) a public hospital Lagos, Nigeria. Methods Medical records all AKI managed between July 2010 and March 2013 were reviewed. Results Seventeen mean (SEM) age 3.8 (0.8) years received 0 - 18 days; about half infants. was provided...
Sub-Saharan Africa is the epicentre of HIV pandemic but there are few reports HIV-related kidney diseases in children this region. This study aimed to determine prevalence proteinuria HIV-infected at Lagos University Teaching Hospital. Proteinuria was determined using urine protein-creatinine ratio. CD4+ cell count for all children. The mean age 74.4 +/- 35.6 months with a male: female ratio 3:2. Compared 6% 50 controls 20.5% 88 had (p = 0.026). Of 20 advanced clinical stage 40% compared...
Recent reports from both Caucasian and black populations suggest changes in steroid responsiveness of childhood nephrotic syndrome. This study was therefore undertaken to determine the features sensitivity pattern a cohort children with Records managed for syndrome January 2008 April 2013 were reviewed. Details including age, response treatment, renal histology analysed. There 108 (median age: 5.9 years, peak: 1-2 years), 90.2% whom had idiopathic Steroid 82.8% among but 75.9% overall....
Background: Steroid-resistant nephrotic syndrome (SRNS) is a leading cause of end-stage kidney disease in children and young adults. Despite advances genomic science that have led to the discovery >50 monogenic causes SRNS, there are no clear guidelines for genetic testing clinical practice. Methods: Using high throughput sequencing, we evaluated 492 individuals from 181 families mutations 40 known SRNS genes. Causative were defined as missense, truncating, obligatory splice site variants...
Sickle cell anaemia (SCA) is associated with growth failure. However, recent reports indicate high rates of overweight or obesity among children SCA in developed countries. It unclear whether also common developing The objectives the study were to determine prevalence obesity, wasting and stunting identify predictors Nigeria.Children attending a public-funded tertiary hospital clinic studied. Weight, height, haemoglobin, haemoglobin fractions white count measured. Anthropometric values...
The prevalence of acute kidney injury (AKI) in children with severe malaria sub-Saharan African may have been underestimated. study aimed to determine the AKI and its association adverse hospital outcomes.At presentation, we measured complete blood count, serum bilirubin, electrolytes, urea creatinine malaria. At 24 h after hospitalization, repeated measurement. Urine passed first hospitalization was also measured. We defined severity using Kidney Disease: Improving Global Outcome...
Recent reports from small studies in West Africa suggest that Black children may have high rate of steroid sensitivity nephrotic syndrome (SSNS) contrary to long held knowledge. Herein, we determined the proportion with idiopathic (INS) who achieved complete remission therapy and identified factors associated remission.We reviewed medical records 241 INS two centres Lagos 2010 2019. We extracted demographic data, clinical features, laboratory values at time diagnosis, receipt response...
Introduction: irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders (FGIDs) which has been well described in western populations especially as commonest cause recurrent abdominal pain The aim this study was to document prevalence Irritable amongst children Nigeria and increase aware ness IBS physicians who manage with pain.
Background: Childhood nephrotic syndrome (NS) follows a chronic course in most children. However, little is known about the psychosocial burden of NS on caregivers despite evidence that caregiver or impairment their well-being may alter outcome childhood illnesses. Objectives: To determine frequency and predictors significant psychological distress among children with NS. Design: A cross-sectional study. Setting: Two pediatric nephrology clinics Lagos, Nigeria. Patients: We included primary...
Limited data is available on kidney function in HIV-infected children sub-Saharan Africa. In addition, malnutrition these further reduces the utility of diagnostic methods such as creatinine-based estimates glomerular filtration rate. We determined serum cystatin C level and estimated rate 60 antiretroviral-naïve, apparently healthy age sex matched children.Serum was measured using enzyme-linked immunosorbent assay technique, while Filler's formula. Student t test, Mann Whitney U Pearson chi...