A5067903142- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Diverticular Disease and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal and Anal Carcinomas
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
- Enhanced Recovery After Surgery
- Gastrointestinal Tumor Research and Treatment
- Pelvic floor disorders treatments
- Appendicitis Diagnosis and Management
- Frailty in Older Adults
- Cancer survivorship and care
- Climate Change and Health Impacts
- Gastrointestinal Bleeding Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
- COVID-19 and healthcare impacts
- Global Public Health Policies and Epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Palliative Care and End-of-Life Issues
National University of Singapore
2016-2025
National University Health System
2016-2025
National University Hospital
2015-2025
Institute for Musculoskeletal Health
2023-2024
The University of Sydney
2014-2024
Institute for Health Metrics and Evaluation
2021-2024
University of Washington
2021-2024
National University Cancer Institute, Singapore
2021-2024
Royal North Shore Hospital
2023-2024
Wenzhou Medical University
2024
Dendritic cells (DCs) are professional antigen-presenting that hold great therapeutic potential. Multiple DC subsets have been described, and it remains challenging to align them across tissues species analyze their function in the absence of macrophage contamination. Here, we provide validate a universal toolbox for automated identification DCs through unsupervised analysis conventional flow cytometry mass data obtained from multiple mouse, macaque, human tissues. The use minimal set...
BackgroundBenign prostatic hyperplasia is a common urological disease affecting older men worldwide, but comprehensive data about the global, regional, and national burden of benign its trends over time are scarce. As part Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2019, we estimated global in, prevalence of, disability-adjusted life-years (DALYs) due to hyperplasia, in 21 regions 204 countries territories from 2000 2019.MethodsThis study was conducted with GBD 2019...
<h2>Summary</h2><h3>Background</h3> Gout is an inflammatory arthritis manifesting as acute episodes of severe joint pain and swelling, which can progress to chronic tophaceous or erosive gout, both. Here, we present the most up-to-date global, regional, national estimates for prevalence years lived with disability (YLDs) due gout by sex, age, location from Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2021, well forecasted 2050. <h3>Methods</h3> YLDs 1990 2020 were estimated...
Background Cancer is likely to remain the most prevalent noncommunicable disease in high-income countries with an older population. Interestingly, no review of attitudes toward telemedicine among adults has been performed. This be group affected by both cancer and increasing use technology health care. Objective We aimed map research on acceptance who are patients. Methods conducted a scoping review. PubMed, EMBASE, PsycINFO, CINAHL, Cochrane Central Register Controlled Trials were...
Abstract Circular RNAs (circRNAs) are produced by head-to-tail back-splicing which is mainly facilitated base-pairing of reverse complementary matches (RCMs) in circRNA flanking introns. Adenosine deaminases acting on RNA (ADARs) known to bind double-stranded for adenosine inosine (A-to-I) editing. Here we characterize ADARs as potent regulators circular transcriptome identifying over a thousand circRNAs regulated bidirectional manner through and beyond their editing function. We find that...
Most mammalian genes generate messenger RNAs with variable untranslated regions (UTRs) that are important post-transcriptional regulators. In cancer, shortening at 3' UTR ends via alternative polyadenylation can activate oncogenes. However, internal splicing remains poorly understood as studies have traditionally focused on protein-coding alterations. Here we systematically map the pan-cancer landscape of and present this in SpUR ( http://www.cbrc.kaust.edu.sa/spur/home/ ). is widespread,...
Background The effectiveness of somatic neoantigen-based immunotherapy is often hindered by the limited number mutations in tumors with low to moderate mutation burden. Focusing on microsatellite-stable colorectal cancer (CRC), this study investigates potential tumor-associated circular RNAs (circRNAs) as an alternative source neoepitopes CRC. Methods Tumor-associated circRNAs CRC were identified using MiOncoCirc database and ribo-depletion RNA sequencing paired clinical normal tumor...
Abstract Viruses are a key component of the colon microbiome, but relationship between virome and colorectal cancer (CRC) remains poorly understood. We seek to identify alterations in viral community that is characteristic CRC examine if they persist after surgery. Forty-nine fecal samples from 25 non-cancer (NC) individuals 12 patients, before 6-months surgery, were collected for metagenomic analysis. The patients demonstrated an increased network connectivity as compared NC individuals....
The ideal surgery following seton insertion for high anal fistulas remains debatable.This study aimed to compare the success between endorectal advancement flap and ligation of intersphincteric fistula tract techniques as definitive procedure placement.This is a retrospective review.This was conducted at Division Colorectal Surgery, University Surgical Cluster, National Health System, Singapore, April 2006 July 2011.After placement fistulas, 31 24 patients underwent procedures.Failure...
Sacrectomy is sometimes necessary to achieve negative margins in pelvic exenteration procedures. This typically done with the patient prone position. Some of limitations approach include its limited access lateral sidewall structures and suboptimal vascular control comparison a combined abdominolithotomy approach.This article describes technique for performing low sacrectomy (below sacroiliac joint) through transabdominal without need turn intraoperatively.The procedure involves 2...
Abstract Globally, colorectal cancer (CRC) is the third most frequently occurring cancer. Progression on to an advanced metastatic malignancy (metCRC) often indicative of poor prognosis, as 5-year survival rates patients decline rapidly. Despite availability many systemic therapies for management metCRC, long-term efficacies these regimens are hindered by emergence treatment resistance due intratumoral and intertumoral heterogeneity. Furthermore, not all have associated biomarkers that can...