A5087229893- RNA modifications and cancer
- RNA regulation and disease
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Protein Degradation and Inhibitors
- CRISPR and Genetic Engineering
- Ubiquitin and proteasome pathways
- Sarcoma Diagnosis and Treatment
- Advanced Glycation End Products research
- Working Capital and Financial Performance
- Cardiac Ischemia and Reperfusion
- Banking stability, regulation, efficiency
- CAR-T cell therapy research
- Cholesterol and Lipid Metabolism
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Glioma Diagnosis and Treatment
- Cancer-related gene regulation
- Advanced Nanomaterials in Catalysis
- Bioinformatics and Genomic Networks
- Lipid metabolism and disorders
- Genomics and Chromatin Dynamics
- Acute Kidney Injury Research
National University Cancer Institute, Singapore
2018-2023
National University of Singapore
2018-2023
Center for Excellence in Molecular Cell Science
2022
Chinese Academy of Sciences
2022
Renmin Hospital of Wuhan University
2022
Wuhan University
2022
Xi'an University of Science and Technology
2021
Significance Glioblastoma (GBM) cells develop intrinsic or acquired insensitiveness to BET bromodomain inhibitors (BBIs) yet persistent protein dependency. Selective degradation of proteins by a next-generation chemical compound undermines the dependency and exerts superior antineoplastic effects over inhibition bromodomain. Given significant difference between in GBM cells, chemically induced serves as promising strategy overcome anticipated clinical BBIs resistance.
Abstract Circular RNAs (circRNAs) are produced by head-to-tail back-splicing which is mainly facilitated base-pairing of reverse complementary matches (RCMs) in circRNA flanking introns. Adenosine deaminases acting on RNA (ADARs) known to bind double-stranded for adenosine inosine (A-to-I) editing. Here we characterize ADARs as potent regulators circular transcriptome identifying over a thousand circRNAs regulated bidirectional manner through and beyond their editing function. We find that...
Liposarcomas (LPSs) are a group of malignant mesenchymal tumors showing adipocytic differentiation. Here, to gain insight into the enhancer dysregulation and transcriptional addiction in this disease, we chart super-enhancer structures both LPS tissues cell lines. We identify bromodomain extraterminal (BET) protein-cooperated FUS-DDIT3 function myxoid BET protein-dependent core regulatory circuitry consisting FOSL2, MYC, RUNX1 de-differentiated LPS. Additionally, SNAI2 is identified as...
RNA editing introduces nucleotide changes in sequences. Recent studies have reported that aberrant adenosine-to-inosine is implicated cancers. Until now, very few functionally important protein-recoding targets been discovered. Here, we investigated the role of a recently discovered target COPA (coatomer subunit α) hepatocellular carcinoma (HCC).Clinical implication was studied cohort 125 HCC patients. CRISPR/Cas9-mediated knockout site complementary sequence (ECS) used to delete edited...
Molecular profiling of the most aggressive brain tumor glioblastoma (GBM) on basis gene expression, DNA methylation, and genomic variations advances both cancer research clinical diagnosis. The enhancer architectures regulatory circuitries governing tumor-intrinsic transcriptional diversity subtype identity are still elusive. Here, by mapping H3K27ac deposition, we analyze active landscapes across 95 GBM biopsies, 12 normal tissues, 38 cell line counterparts. Analyses differentially...
The dynamic regulation of alternative splicing requires coordinated participation multiple RNA binding proteins (RBPs). Aberrant caused by dysregulation regulatory RBPs is implicated in numerous cancers. Here, we reveal a frequently overexpressed cancer-associated protein, DAP3, as RBP cancer. Mechanistically, DAP3 coordinates networks, not only via mediating the formation ribonucleoprotein complexes to induce substrate-specific changes, but also modulating factors cause indirect effect on...
Abstract Soft tissue sarcoma (STS) is a heterogeneous disease that arises from connective tissues. Clinical outcome of patients with advanced tumors especially de-differentiated liposarcoma and uterine leiomyosarcoma remains unsatisfactory, despite intensive treatment regimens including maximal surgical resection, radiation, chemotherapy. MAP kinase-interacting serine/threonine-protein kinase 1 2 (MNK1/2) have been shown to contribute oncogenic translation via phosphorylation eukaryotic...
Abstract Gastric cancer cases are often diagnosed at an advanced stage with poor prognosis. Platinum-based chemotherapy has been internationally accepted as first-line therapy for inoperable or metastatic gastric cancer. To achieve greater benefits, selection of patients eligible this treatment is critical. Although gene expression profiling widely used a genomic classifier to identify molecular subtypes and stratify different regimens, its prediction accuracy can be improved....
Abstract Background & Aims Gastric cancer (GC) cases are often diagnosed at an advanced stage with poor prognosis. Platinum-based chemotherapy has been internationally accepted as first-line therapy for inoperable or metastatic GC. To achieve greater benefits, it is critical to select patients who eligible the treatment. Albeit gene expression profiling widely used a genomic classifier identify molecular subtypes of GC and stratify different regimens, prediction accuracy remains be...
<div>Abstract<p>Gastric cancer cases are often diagnosed at an advanced stage with poor prognosis. Platinum-based chemotherapy has been internationally accepted as first-line therapy for inoperable or metastatic gastric cancer. To achieve greater benefits, selection of patients eligible this treatment is critical. Although gene expression profiling widely used a genomic classifier to identify molecular subtypes and stratify different regimens, its prediction accuracy can be...
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