A5007848472- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal and Vascular Pathologies
- Sirtuins and Resveratrol in Medicine
- Ophthalmology and Visual Impairment Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neurological Disorders and Treatments
- Autophagy in Disease and Therapy
- Ophthalmology and Eye Disorders
- Cardiac Ischemia and Reperfusion
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Glycation End Products research
- Hormonal Regulation and Hypertension
- Liver Disease Diagnosis and Treatment
- Chemotherapy-induced organ toxicity mitigation
- Adenosine and Purinergic Signaling
- Muscle and Compartmental Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Immune cells in cancer
- Genomics, phytochemicals, and oxidative stress
- Methemoglobinemia and Tumor Lysis Syndrome
- Dialysis and Renal Disease Management
- Systemic Lupus Erythematosus Research
Wuhan University
2011-2025
Renmin Hospital of Wuhan University
2009-2025
Sun Yat-sen University
2022-2024
Tianjin Medical University General Hospital
2012-2013
Tianjin Medical University
2012-2013
Arkana Laboratories
2006
Acute kidney injury (AKI) is often secondary to sepsis. Increasing evidence suggests that mitochondrial dysfunction contributes the pathological process of AKI. In this study, we aimed examine regulatory roles Sirt3 in Lipopolysaccharide (LPS)-induced damage renal tubular epithelial cells (TECs). knockout mice were intraperitoneally injected with LPS, and cultured TECs stimulated LPS evaluate effects on structure function TECs. Electron microscopy was used assess morphology....
Reactive oxygen species (ROS) overproduction and renal tubular epithelial cell (TEC) apoptosis are key mechanisms of contrast-induced acute kidney injury (CI-AKI). Mitochondria the main source intracellular ROS. In present study, characteristics mitophagy effects rapamycin on abnormalities in oxidative stress, mitochondrial mitophagy, TEC function were investigated a CI-AKI rat model. Rats divided into control group, pretreatment groups (with dose 2 or 5 mg/kg). was induced by...
Disturbed renal lipid metabolism, especially cholesterol dysregulation plays a crucial role in the pathogenesis of chronic kidney disease (CKD).We recently reported that angiotensin (Ang) II could induce accumulation and injury podocytes.However, underlying mechanisms for these alterations remain unknown.Methods: Bioinformatics analysis biopsy specimens from patients with hypertensive nephropathy (HN) suggests involvement Sirtuin 6 (Sirt6) Ang II-induced glomerular cholesterol.Using...
Renal fibrosis and vascular rarefaction are significant complications of ischemia/reperfusion (I/R) injury. Human umbilical cord mesenchymal cell-derived exosomes (hucMSC-exos) have shown potential in mitigating these conditions. This study investigates the role miR-29a-3p its therapeutic effects on I/R-induced renal damage. Male C57BL/6 mice were subjected to unilateral ischemia for 28 min followed by reperfusion. Exosomes mimics/inhibitors injected into mice. function, histological...
Sepsis-associated acute kidney injury (SA-AKI) is a prevalent and severe complication of sepsis, but its complex pathogenesis remains unclear. This study aims to identify potential biomarkers for SA-AKI by elucidating molecular mechanisms through bioinformatics methods. Transcriptional data related were obtained from the Gene Expression Omnibus (GEO) database. We used differentially expressed genes (DEGs) weighted gene co-expression network analysis (WGCNA) characteristic associated with...
Sirt6 upregulation inhibited Ang II-induced ROS generation and DNA DSBs in podocytes, it shows the cytoprotective effects podocytes via Nrf2/HO-1 pathway. may be a new therapeutic target for treatment of CKD.
<b><i>Background:</i></b> Renal tubular cell apoptosis is a key mechanism of contrast-induced acute kidney injury. It has been reported that endoplasmic reticulum (ER) stress the underlying high osmolar renal apoptosis. Whether ER involved in low injury remains unclear. In present study, roles iopromide-induced (a contrast) and effects N-acetylcysteine (NAC) on were investigated. <b><i>Methods:</i></b> NRK-52E cells exposed to different...
The source of IgA and the mechanism for deposition in mesangium remain unknown primary nephropathy. Because CD19+CD5+ B cells are important producers contribute to several autoimmune diseases, they may play an role In this study, flow cytometry, quantitative PCR, confocal microscopy were used assess frequency, distribution, Ig production, CD phenotypes, cytokine sensitivity apoptosis peripheral blood, peritoneal fluid, kidney biopsies 36 patients with All nephropathy significantly more...
<i>Background:</i> Whether hypercholesterolemia is a risk factor for contrast-induced acute kidney injury (CI-AKI) remains unclear. In the present study, effects of short- and long-term dietary on contrast media-induced nephrotoxicity were evaluated. <i>Methods:</i> Rats fed either normal rodent diet (N) or high-cholesterol (H). At end 2 8 weeks, rats from each group given tail vein injection iohexol (group NC HC) vehicle N H). Blood lipids, renal function...
Acute kidney injury (AKI) is a devastating comorbidity in sepsis and correlates with very poor prognosis increased mortality. Currently, we use lipopolysaccharide (LPS) to establish sepsis-related AKI try demonstrate the pathophysiological role of microRNA-214-5p (miR-214-5p) this process. Mice were intravenously injected miR-214-5p agomir, antagomir or negative controls for three consecutive days then received single intraperitoneal injection LPS (10 mg/kg) 24 h induce AKI. Besides, Boston...
<b><i>Background:</i></b> The precise mechanisms underlying radiocontrast nephropathy (RCN) are not well understood. Intracellular Ca<sup>2+</sup> overload is considered to be a key factor in RCN. Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) system one of the main pathways intracellular overload. We investigated whether via NCX was involved contrast-induced renal tubular cytotoxicity. <b><i>Methods:</i></b>...
Previous studies have shown that children with intermittent exotropia (IXT) a higher rate of psychiatric abnormalities as they grow up, such attention deficit. This study explored visual and hearing among IXT, evaluated its association clinical characteristics cognitive development. Forty-nine diagnosis IXT 29 traditional development were recruited. The Integrated Visual Auditory Continuous Performance Test (IVA-CPT) was used to measure the subjects' full-scale response control quotient...
Abstract Hypercholesterolemia can aggravate contrast‐induced acute kidney injury, and the exacerbation of renal tubular epithelial cell (RTEC) injury is a major cause. However, exact mechanisms remain obscure. Mitophagy, type autophagy, selectively eliminates damaged mitochondria reduces mitochondrial oxidative stress, which strongly implicated in homeostasis injury. Oxidized low‐density lipoprotein (Ox‐LDL) accumulated hypercholesterolemia has cytotoxic effect. This study aimed to determine...
IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, accounting for approximately 30-40% of patients undergoing renal biopsy in Asia. The characteristic and diagnostic lesion IgAN deposition glomerular IgA. morphological lesions observed by light microscopy are extremely variable. A causal relationship between burn injury has not been established, correlation them clear if they appear at same time. We have explored cause severe proteinuria a Chinese patient with...
Abstract Background Contrast-induced acute kidney injury (CI-AKI) is the onset of renal failure occurring 24–48 hours after intravascular injection contrast medium (CM), which a common cause hospital-acquired injury. Previous researches on CI-AKI have demonstrated that cytoplasmic Ca 2+ overload and mitochondrial damage were strongly associated with CI-AKI, but precise pathogenesis remains elusive. Therefore, we aimed to identify role calcium uniporter (MCU), most important unidirectional...
Lymphoblastic lymphoma (LBL) is a highly malignant form of with rapid progression and high mortality. According to the World Health Organization immunophenotype, it classified into T-lymphoblastic (T-LBL) B-lymphoblastic (B-LBL). B-LBL often involves lymph nodes extranodal locations, such as skin, bones, soft tissues. However, renal damage an initial symptom very rare in B-LBL. The present study presented case involvement 30-year-old male patient presenting acute failure bilateral...