Purpose: To evaluate the longitudinal changes in subfoveal choroidal thickness (SFCT) children with different refractive status. Methods: A total of 2290 3 to 14 years old who attended first year kindergarten (G0), primary school (G1), fourth (G4), or junior high (G7) Guangzhou, China, were recruited and followed up for 2 years. All participants received cycloplegic autorefraction, axial length measurement SFCT using a CIRRUS HD-OCT device. Children divided into groups persistent non-myopia...

Purpose To identify the relationship between increase in axial length (AL) and height school-age children explore influence of refractive status on such a relationship. Methods In this 5-year cohort study, 414 Chinese (237 boys) aged 6–9 years (mean 7.12) underwent measurements annually. AL was measured using Lenstar; with standing, without shoes; refraction subjective cycloplegia. Participants were divided according to status: persistent emmetropia, myopia, newly developed myopia. The...

AIM: To investigate the underlying factors by establishing a new paradigm for assessing control ability under stereopsis testing conditions. METHODS: This was prospective observational study. We evaluated of intermittent exotropia (IXT) patients in three conditions: natural 2D optotype viewing, viewing with polarized glasses, and 3D glasses. Recording smartphone, we captured videos to analyze accurate time spontaneous exodeviation subsequent realignment before after breaking fusion....

To examine the association of ADHD and LD with visual impairment, uncorrected refractive error, error (myopia, hyperopia, astigmatism) among US children adolescents. A population-based cross-sectional study included 3,385 participants aged 12-15 years from large, representative sample NHANES. The diagnoses in adolescents, as reported by parents or adolescents themselves, were analyzed. All participants' right eyes used to calculate spherical equivalent errors (SER) during investigation....

Binocular imbalance is known to inhibit stereopsis. This study investigates whether an imbalanced context around stereo stimuli also affects local stereopsis and explores the underlying mechanisms. Three experiments were conducted with normally sighted participants. Experiment 1 measured detection thresholds under three conditions: binocular balance (0.5 vs. 0.5 contrast), left-eye dominance (0.8 0.2 right-eye (0.2 0.8 contrast). 2 assessed modulation of effect by context-target...

To explore whether there is a difference in postoperative extraocular muscle (EOM) remodeling between 1-month-old and 3-month-old rabbits. Recession (n = 16) resection were performed on the right superior rectus (SR) muscles of SR tissues harvested 1 4 weeks post-surgery for each group), mid-belly sections used to assess myosin heavy chain (MyHC) isoform expression (fast 2X, embryonic, neonatal MyHCs), activated satellite cells (SCs), centrally nucleated myofibers. Age-matched unoperated...

Purpose.: To investigate the choroidal thickness (CT) in children with amblyopia through spectral-domain optical coherence tomography (SD-OCT). Methods.: Thirty-seven unilateral and 22 normal vision participated study. Cross-sectional images of choroid evaluated eyes were obtained by SD-OCT. The was measured directly below fovea at eight other locations: 1 2 mm superior, temporal, inferior, nasal to fovea. researchers compared among amblyopic eyes, fellow amblyopia, vision. Age, sex,...

Purpose: To quantify retinal vascular density in amblyopic children and to investigate the relationship between superficial deep vessel thickness. Method: In this prospective cross-sectional study, 85 (5–12 years) 66 age-matched control subjects participated at a pediatric ophthalmology clinic. Macular densities of capillary plexuses (SCP, DCP, respectively) thickness were measured by clinical optical coherence tomographic angiography (OCTA). Vessel compared groups group, correlations among...

Stargardt Disease (STGD) is the commonest genetic form of juvenile or early adult onset macular degeneration, which a genetically heterogeneous disease. Molecular diagnosis STGD remains challenge in significant proportion cases. To address this, seven patients from five putative families were recruited. We performed capture next generation sequencing (CNGS) probands and searched for potentially disease-causing variants previously identified retinal dystrophy genes. Seven mutations ABCA4 two...

To investigate the longitudinal changes in myopia from onset to stabilization school-aged children with single-vison lenses (SVLs).The medical records of patients wearing SVLs long-term follow-up data between 2006 and 2016 were retrospectively reviewed. The who 6-10 years old at initial visit 16 last assessment included analysed. periods progression evaluated by plotting fitted curves spherical equivalent (SE).Seven hundred seventy-three (median age 9 years) accessed over an average 7 (IQR,...

With increasing axial length and myopia progression, the micro-structure of retina choroid gradually changes. Our study describes longitudinal changes in retinal choroidal thickness school-aged children with explores relationship between progression.An exploratory analysis a randomized trial was performed. Children (n = 168, aged 7 to 12 years) from - 0.75 dioptre (D) 4.00 D were enrolled this prospective study. Cycloplegic refraction, (AL), thicknesses measured at baseline 1- 2-year...

Background: The physical process of axial length growth among children and its role in the occurrence myopia remain insufficiently explored. In this study, we investigate patterns ocular persistent (PM) non-myopia (PNM) aged 3 to 15 years. Methods: A group 6353 years, selected from rural schools China, were followed up annually for 2 Biometric measurements including (AL) spherical equivalent refraction (SER) obtained. Body height was recorded. Children divided into two groups: PM defined as...

Purpose To use highly precise spectral-domain optical coherence tomography (SD-OCT) to determine whether there were structural abnormalities in the layers of different regions fovea children with anisometropic amblyopia. Methods Eighteen (mean age 7.8 years old; range 5–11 years) unilateral amblyopia and 18 age-matched control subjects participated. Foveal thickness was measured an enhanced depth imaging system, SD-OCT segmented into using custom developed software. The each layer compared...

AIM: To identify the genetic defects of a Chinese patient with sporadic retinitis pigmentosa (RP). METHODS: Ophthalmologic examinations were performed on RP patient, 144 genes associated retinal diseases scanned capture next generation sequencing (CNGS) approach. Two heterozygous mutations in PDE6B confirmed pedigree by Sanger subsequently. The carrier frequency reported based available two public exome databases (1000 Genomes Project and ESP6500 Project) one in-house database was...

Objectives Infantile nystagmus (IN) is a genetically heterogeneous condition characterised by involuntary rhythmic oscillations of the eyes accompanied different degrees vision impairment. Two genes have been identified as mainly causing IN: FRMD7 and GPR143 . The aim our study was to identify genetic basis both sporadic IN X-linked IN. Design Prospective analysis. Patients Twenty Chinese patients, including 15 cases 5 from families, were recruited underwent molecular We first performed...

Previous studies have shown that children with intermittent exotropia (IXT) a higher rate of psychiatric abnormalities as they grow up, such attention deficit. This study explored visual and hearing among IXT, evaluated its association clinical characteristics cognitive development. Forty-nine diagnosis IXT 29 traditional development were recruited. The Integrated Visual Auditory Continuous Performance Test (IVA-CPT) was used to measure the subjects' full-scale response control quotient...

Purpose: To analyze the appearance of supraciliochoroidal fluid (SCF) within 1 week after trabeculectomy with anterior segment optical coherence tomography (AS-OCT), a high-resolution, non-contact detection method.Methods: In this prospective, non-comparative study, AS-OCT was used to assess incidence SCF in 25 eyes 22 glaucoma patients who underwent trabeculectomy. Eyes were examined for before and at 1, 3 days, surgery. additionally 2, 3, 4, 8 postoperative weeks. intraocular pressure...

To evaluate the longitudinal impact on health-related quality of life (HRQOL) during amblyopia treatment for school-aged children from children's perspective.School-aged prescribed first time were recruited into current study. Using a questionnaire, subjects' HRQOL was assessed before patching treatment, and at 8 weeks 16 after commencement treatment. Evaluation visual function psychosocial aspect included in questionnaire. Visual acuity demographic data subjects recorded.Forty-four...

To evaluate whether clinical measures of postoperative binocular functions could predict the long-term stability ocular alignment in children with intermittent exotropia. A retrospective study was performed thirty-nine (median: 7 years) who have been surgically treated from exotropia without overcorrection (less than 10 prism diopters [pd] exodeviation at 1 month postoperatively). Angles deviation and were measured preoperatively month, 6 months, final follow-up visit (≥24 months)...

Background: To assess the clinical effectiveness of orthoptic therapy in postoperative stabilisation and rehabilitation binocular function children with intermittent exotropia (IXT) after surgery. Methods: This was a prospective, parallel, randomised controlled trial. A total 136 IXT patients (aged from 7 to 17 years) who had been successfully corrected at 1 month surgery were enrolled this study, 117 (58 controls) completed 12-month follow-up visit. The primary outcome established as...

This study was designed to investigate whether 5-fluorouracil (5-Fu)-polycaprolactone sustained-release film in Ahmed glaucoma valve implantation inhibits postoperative bleb scarring rabbit eyes. Eighteen New Zealand white rabbits were randomly divided into three groups (A, B and C; n = 6 per group). Group A received combined 5-Fu-polycaprolactone application implantation, group local infiltration of 5-Fu C implantation. Postoperative observations made the anterior segment, intraocular...