A5102023159- Advanced biosensing and bioanalysis techniques
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Circadian rhythm and melatonin
- DNA and Biological Computing
- Birth, Development, and Health
- Wnt/β-catenin signaling in development and cancer
- S100 Proteins and Annexins
- Advanced Glycation End Products research
- Genetic and Kidney Cyst Diseases
- CRISPR and Genetic Engineering
- TGF-β signaling in diseases
- Molecular Communication and Nanonetworks
- Genomics, phytochemicals, and oxidative stress
- Hippo pathway signaling and YAP/TAZ
- Dialysis and Renal Disease Management
- Inflammatory mediators and NSAID effects
- RNA and protein synthesis mechanisms
- Bone Metabolism and Diseases
Qingdao University of Science and Technology
2023-2024
Wuhan University
2019-2021
Renmin Hospital of Wuhan University
2021
Air Force Medical University
2021
Johns Hopkins University
2021
Johns Hopkins Medicine
2021
University of Michigan
2007
The Hippo pathway plays a key role in organ size control by regulating cell proliferation and apoptosis Drosophila . Although recent genetic studies have shown that the is regulated NF2 Fat tumor suppressors, physiological regulations of this are unknown. Here we show mammalian cells, transcription coactivator YAP (Yes-associated protein), inhibited density via pathway. Phosphorylation Lats suppressor kinase leads to cytoplasmic translocation inactivation oncoprotein. Furthermore,...
CRISPR/Cas12a has been believed to be powerful in molecular detection and diagnostics due its amplified trans-cleavage feature. However, the activating specificity multiple activation mechanisms of Cas12a system are yet elucidated fully. Herein, a "synergistic activator effect" is discovered, which supports an mechanism that synergistic incorporation two short ssDNA activators can promote CRISPR/Cas12a, while either them too work independently. As proof-of-concept example,...
Sirt6 upregulation inhibited Ang II-induced ROS generation and DNA DSBs in podocytes, it shows the cytoprotective effects podocytes via Nrf2/HO-1 pathway. may be a new therapeutic target for treatment of CKD.
Accurate classification of tumor cells is importance for cancer diagnosis and further therapy. In this study, we develop multimolecular marker-activated transmembrane DNA computing systems (MTD). Employing the cell membrane as a native gate, MTD system enables direct signal output following simple spatial events "transmembrane" "in-cell target encounter", bypassing need multistep conversion. The comprises two intelligent nanorobots capable independently sensing three molecular markers (MUC1,...
Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. GWAS have identified hundreds loci influencing BMD, but few been functionally analyzed. In this study, we show that SNPs within BMD locus on chromosome 14q32.32 alter splicing and expression PAR-1a/microtubule affinity regulating kinase 3 (MARK3), conserved serine/threonine known to regulate bioenergetics, cell division, polarity. Mice lacking Mark3 either globally or selectively in osteoblasts increased...
Objective To observe functional changes of renal tubular epithelial cells stimulated by high mobility group protein box 1 (HMGB1) and associated mechanism. Methods Renal (NRK52E) were divided into control group, HMGB1 HMGB1+ lipopolysaccharide from Rhodobactersphaeroides (LPS RS) group. Toll-like receptor 4 (TLR4) expression was detected immunofluorescence Western blotting. Apoptosis rate cell cycle arrest identified with flow cytometry. The activation MAPK signaling pathway NF-κB IL-...
Increasing evidence suggests that mitochondrial dysfunction plays a critical role in the development of diabetic kidney disease. However, specific pathomechanism by which hyperglycaemia leads to remains unclear. A-kinase anchoring protein (AKAP)1 is scaffold AKAP family involved fission and fusion. Here, we show rats with streptozotocin (STZ)-induced diabetes developed proteinuria podocyte damage accompanied AKAP1 overexpression closely interacted enzyme dynamin-related 1 (Drp1). At...
Abstract Background: Glioma is a common primary central nervous system tumor, and there still lack of effective therapeutic drugs that can effectively improve the survival rate patients in clinical. Bufalin has good effect treatment various tumors, but mechanism how it promotes apoptosis glioma cells unclear. The aim this study was to investigate drug target bufalin acting on cells, clarify apoptosis. Methods: Cell viability proliferation were evaluated by cck-8 colony formation assay. Then,...