A5000055976- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Frailty in Older Adults
- Cardiac tumors and thrombi
- Vascular Tumors and Angiosarcomas
- Cancer Treatment and Pharmacology
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Hypoxia, and Metabolism
- Soft tissue tumors and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Chronic Lymphocytic Leukemia Research
- Nutrition and Health in Aging
- Hepatitis B Virus Studies
- HER2/EGFR in Cancer Research
- Pancreatic and Hepatic Oncology Research
- Hepatitis C virus research
- Cancer Cells and Metastasis
- Tumors and Oncological Cases
- Economic and Financial Impacts of Cancer
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- Neutropenia and Cancer Infections
- Palliative Care and End-of-Life Issues
National University Cancer Institute, Singapore
2014-2024
Freedom House
2023
Icahn School of Medicine at Mount Sinai
2022-2023
Urbana University
2023
Orthogonal (United States)
2023
National University Hospital
2019-2021
National University Health System
2011-2021
University of Florida
2019
NYU Langone Health
2017
Mount Sinai Medical Center
2016-2017
Liposarcomas (LPSs) are a group of malignant mesenchymal tumors showing adipocytic differentiation. Here, to gain insight into the enhancer dysregulation and transcriptional addiction in this disease, we chart super-enhancer structures both LPS tissues cell lines. We identify bromodomain extraterminal (BET) protein-cooperated FUS-DDIT3 function myxoid BET protein-dependent core regulatory circuitry consisting FOSL2, MYC, RUNX1 de-differentiated LPS. Additionally, SNAI2 is identified as...
Hepatitis B virus (HBV) reactivation may occur with chemotherapy and has significant morbidity mortality. The United States Centre for Disease Control Prevention recommends pre-chemotherapy hepatitis screening all cancer patients, while the American Society of Clinical Oncology finds that there is insufficient evidence currently to support such a recommendation. Apart from anthracyclines, HBV rates other commonly used regimens in solid tumours are not well described. We compared risk...
Inflammation in the tumor microenvironment has been shown to promote disease progression pancreatic ductal adenocarcinoma (PDAC); however, role of macrophage metabolism promoting inflammation is unclear. Using an orthotopic mouse model PDAC, we demonstrate that macrophages from tumor-bearing mice exhibit elevated glycolysis. Macrophage-specific deletion Glucose Transporter 1 (GLUT1) significantly reduced burden, which was accompanied by increased Natural Killer and CD8+ T cell activity...
Determine whether specific CTNNB1 or APC mutations in patients with desmoid tumor were associated differences clinical responses to systemic treatments.We established a multi-institutional dataset of previously treated across four U.S. sarcoma centers, including demographic and clinicopathologic characteristics, treatment regimens, radiographic responses. mutation status was determined from prior pathology records, archival tissue requested analyzed by Sanger sequencing and/or...
With an aging population and increasing number of elderly patients with cancer, it is essential for us to understand how cancer physicians approach the management treatment as well their methods diagnosis disclosure older versus younger in Singapore, where routine geriatric oncology service not available.57 who are currently practicing Singapore participated a written questionnaire survey on attitudes towards patient, which included 2 hypothetical clinical scenarios choices fit patient that...
Large numbers of neutrophils infiltrate tumors and comprise a notable component the inflammatory tumor microenvironment. While it is established that cells exhibit Warburg effect for energy production, contribution neutrophil metabolic state to tumorigenesis unknown. Here, we investigated whether infiltration status promotes progression in an orthotopic mouse model pancreatic ductal adenocarcinoma (PDAC). We observed large increase proportion blood upon transplantation. Intriguingly, these...
Abstract Soft tissue sarcoma (STS) is a heterogeneous disease that arises from connective tissues. Clinical outcome of patients with advanced tumors especially de-differentiated liposarcoma and uterine leiomyosarcoma remains unsatisfactory, despite intensive treatment regimens including maximal surgical resection, radiation, chemotherapy. MAP kinase-interacting serine/threonine-protein kinase 1 2 (MNK1/2) have been shown to contribute oncogenic translation via phosphorylation eukaryotic...
// Andrea L.A. Wong 1, 2, 3 , Raghav Sundar 2 Ting-Ting Wang Thian-C Ng 4 Bo Zhang Sing-Huang Tan Thomas I.P. Soh Angela S.L. Pang Chee-Seng Samuel G.W. Ow Lingzhi 3, 5 Jannet Mogro Jingshan Ho Anand D. Jeyasekharan Yiqing Huang Choon-Hua Thng 6 Ching-Wan Chan 7 Mikael Hartman Philip Iau Shaik A. Buhari Boon-Cher Goh Soo-Chin Lee 1 Department of Haematology-Oncology, National University Cancer Institute, Health System, Singapore Haematology Oncology Research Group, Science Singapore,...
Objective . To compare the safety and efficacy of 2 transcutaneous stimulation techniques, pulsed radiofrequency (TPRF) versus electrical nerve (TENS), in chronic shoulder tendonitis. Design A prospective, randomized, double-blind clinical trial. Setting Academic pain service a city hospital. Subjects Fifty patients with sonography-confirmed Methods were randomly allocated into two groups for treatment 3-month follow-ups: Group 1 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract Angiosarcoma (AS) is a rare disease with dismal prognosis. The treatment landscape and prognostic factors for advanced AS, including locally advanced, unresectable, metastatic remain elusive. Asian Sarcoma Consortium an international collaborative effort to understand the sarcoma in Asia. We undertook retrospective chart review of AS patients seen 8 academic centers across Patients complete clinical, treatment, follow‐up data were enrolled. Overall, 276 included into this study; 84...
11032 Background: Aggressive fibromatoses (desmoid tumors, DT) are locally aggressive connective tissue tumors prone to local recurrences. There is a thin line between the morbidity of surgical resection and tumor growth during watchful waiting, particularly so for intra-abdominal DT. remain relatively few data regarding anthracycline (ANTH) therapy in We review experience at our institution DT pts treated with ANTHs, focusing on PLD doxorubicin (ADR). Methods: 132 were center (2003-15). 26...
Abstract Introduction In the National University Cancer Institute, Singapore (NCIS), 2 pilot programs providing (i) surgical prehabilitation before cancer surgery and (ii) geriatric oncology support for older adults planned chemotherapy and/or radiotherapy were merged to form Geriatric Oncology Longitudinal End eNd (GOLDEN) program in 2019 patients from time of their diagnosis, through treatment process, survivorship. Methods Materials Older aged ≥65 years enrolled either prehabilitation,...
Importance The Cancer and Aging Research Group (CARG) prediction model for chemotherapy-related toxic effects has been developed but not yet validated in older Asian adults. In view of differences drug metabolism effect reporting the population, ability this tool to guide cancer treatment decision-making process adults needs be assessed. Objective To examine validity CARG predictive a multiethnic cohort Design, Setting, Participants prognostic study, patients various ethnicities 70 years or...
Clinical trials are now evaluating hypomethylating agents in combination with histone deactylase inhibitors for nasopharyngeal carcinoma and NK/T cell lymphoma. (ClinicalTrials.gov: NCT00336063). W...
770 Background: PK guided dose management and systemic plasma levels of 5FU have shown correlation with both reduced toxicity improved efficacy. However, data for Asian patients are lacking. Levels highly variable doses based on body surface area. Methods: Area under the curve (AUC) was estimated using a nanoparticle immunoassay from Saladax Biomedical (My5-FU). Patients GI cancers receiving de Gramont, FOLFIRI or mFOLFOX6 regimens had 5 sampling time points obtained (reduced to 2 samplings...
619^ Background: The optimal neoadjuvant regimen in HER2+ breast cancer is undefined. We evaluated the efficacy and tolerability of weekly paclitaxel/carboplatin with lapatinib. Methods: stage I-III patients received 4 cycles 3 PCL [IV paclitaxel (P) 80mg/m2 (days 1, 8, 15), carboplatin (C) AUC 2 8), oral lapatinib (L) (750mg daily)] followed by surgery. Lapatinib dose reductions were not allowed. Patients pCR (ypT0N0) adjuvant PCL; those without doxorubicin/cyclophosphamide. All 1 year...