A5072676042- Retinal Diseases and Treatments
- Advanced Glycation End Products research
- Mitochondrial Function and Pathology
- Advanced Algebra and Geometry
- Epigenetics and DNA Methylation
- Radioactivity and Radon Measurements
- Radioactive contamination and transfer
- Heme Oxygenase-1 and Carbon Monoxide
- Plant tissue culture and regeneration
- Phytochemicals and Medicinal Plants
- Adipose Tissue and Metabolism
- Algebraic Geometry and Number Theory
- Algebraic structures and combinatorial models
- Retinal Imaging and Analysis
- Diabetes and associated disorders
- Research on Leishmaniasis Studies
- Agricultural Economics and Practices
- Adenosine and Purinergic Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Genomics, phytochemicals, and oxidative stress
- Groundwater and Isotope Geochemistry
- Survey Sampling and Estimation Techniques
- Cardiovascular Health and Risk Factors
- Water Quality and Pollution Assessment
- Natural Antidiabetic Agents Studies
Tufts University
2024-2025
Boston University
2025
Royal North Shore Hospital
2024
Mercer University
2022-2024
Institute for Musculoskeletal Health
2024
Banaras Hindu University
2008-2024
Institute of Medical Sciences
2011-2024
Institute for Health Metrics and Evaluation
2024
The University of Sydney
2024
University of Kota
2023-2024
<h2>Summary</h2><h3>Background</h3> Gout is an inflammatory arthritis manifesting as acute episodes of severe joint pain and swelling, which can progress to chronic tophaceous or erosive gout, both. Here, we present the most up-to-date global, regional, national estimates for prevalence years lived with disability (YLDs) due gout by sex, age, location from Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2021, well forecasted 2050. <h3>Methods</h3> YLDs 1990 2020 were estimated...
Purpose.: Increase in reactive oxygen species (ROS) is one of the major retinal metabolic abnormalities associated with development diabetic retinopathy. NF-E2–related factor 2 (Nrf2), a redox sensitive factor, provides cellular defenses against cytotoxic ROS. In stress conditions, Nrf2 dissociates from its cytosolic inhibitor, Kelch like-ECH-associated protein 1 (Keap1), and moves to nucleus regulate transcription antioxidant genes including catalytic subunit glutamylcysteine ligase (GCLC),...
Purpose: Retinal mitochondria are dysfunctional in diabetes, and mitochondrial DNA (mtDNA) is damaged its transcription compromised. Our aim was to investigate the role of mtDNA methylation development diabetic retinopathy. Methods: Effect high glucose (20 mM) on analyzed retinal endothelial cells by methylation-specific PCR quantifying 5-methylcytosine (5mC). Dnmt1 binding at D-loop Cytb regions chromatin immunoprecipitation. The cell death confirmed transcripts mtDNA-encoded genes (Cytb,...
Diabetic retinopathy is a multifactorial disease, and the exact mechanism of its pathogenesis remains obscure. Sirtuin 1 (Sirt1), multifunctional deacetylase, implicated in regulation many cellular functions gene transcription, retinal Sirt1 inhibited diabetes. Our aim was to determine role development diabetic elucidate molecular downregulation. Using Sirt1-overexpressing mice that were for 8 months, structural, functional, metabolic abnormalities investigated vascular neuronal retina. The...
Diabetes induces oxidative imbalance in the retina and impairs Nrf2-mediated antioxidant response, elevates Keap1, cytoplasmic repressor of Nrf2. The goal this study was to understand role epigenetic modifications at Keap1 promoter regulation Nrf2 function.The effect high glucose on binding transcriptional factor Sp1 histone methylation status investigated retinal endothelial cells. Role confirmed cells transfected with siRNA methyltransferase enzyme Set7/9 (SetD7). In vitro results were...
Oxidative stress plays a central role in the development of diabetic retinopathy, and pathogenesis this blinding disease, activation NADPH oxidase 2 (Nox2)-mediated cytosolic reactive oxygen species (ROS) production precedes mitochondrial damage. The multicomponent Nox2 has an obligatory component, Ras-related C3 botulinum toxin substrate 1 (Rac1); diabetes, Rac1 is functionally transcriptionally active. Diabetes also facilitates many epigenetic modifications, activates both DNA methylating...
Purpose.: Mitochondrial DNA (mtDNA) is damaged in the retina diabetes, and mitochondria copy numbers are decreased. The displacement-loop (D-loop) of mtDNA, region with transcription/replication elements, experiences more damage than other regions mtDNA. Our aim was to examine role mismatch repair (MMR) homeostasis diabetic retinopathy, its continued progression after cessation hyperglycemia.
ABSTRACT Traces of uranium were measured by laser fluorimeter in 235 subsurface water samples collected from four districts Punjab state India. The concentration U ranged between <2–644 μg/L with a mean value 73.1 μg/L. radiological risk was observed to be the range 5.55 × 10−6–1.78 10−3 2.03 10−4, which is around 22% more than maximum acceptable level (l.67 10−4) as per guidelines India's Atomic Energy Regulatory Board. chemical toxicity risk, expressed life time average daily dose (LADD)...
Purpose: Diabetes activates matrix metalloproteinase-9 (MMP-9), and MMP-9 via damaging retinal mitochondria, capillary cell apoptosis. promoter has binding sites for many transcription factors, in diabetes its undergoes epigenetic modifications, including histone modifications DNA methylation. Enhancer of Zeste homolog 2 (Ezh2), which catalyzes dimethylation/trimethylation 3 lysine 27 (H3K27me2 me3), is also associated with Our aim was to investigate link(s) between the regulation MMP-9....
Clinical and experimental studies have shown that diabetic retinopathy progression does not halt after termination of hyperglycemia, suggesting a "metabolic memory" phenomenon. DNA is highly dynamic, cytosine methylation changes can last for several years. In diabetes, regulates expression many genes associated with retinal mitochondrial homeostasis. Our aim was to investigate the role in metabolic memory.Reversal 4 days 20 mM glucose by 8 5 glucose, presence/absence Dnmt inhibitor...
The growing incidence of chronic kidney disease remains a global health problem. Obesity is major risk factor for type-2 diabetes and renal impairment. Perirenal adiposity, by virtue its anatomical proximity to the kidneys may cause through paracrine mechanisms that include increased production inflammatory cytokines. Although heme-oxygenase (HO) cytoprotective, effects on perirenal adiposity diabetic nephropathy in Zucker-diabetic fatty rats (ZDFs) largely unclear. Upregulating HO-system...