A5010009334- Helicobacter pylori-related gastroenterology studies
- Oral microbiology and periodontitis research
- Ginger and Zingiberaceae research
- Hormonal Regulation and Hypertension
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Advanced Glycation End Products research
- Estrogen and related hormone effects
- Gastrointestinal motility and disorders
- Genomics, phytochemicals, and oxidative stress
- Ion Channels and Receptors
- Quinazolinone synthesis and applications
- Medicinal Plant Extracts Effects
- Phenothiazines and Benzothiazines Synthesis and Activities
- Biochemical effects in animals
- Phytochemicals and Antioxidant Activities
- Synthesis and Biological Evaluation
- Aldose Reductase and Taurine
- Bone and Dental Protein Studies
- Mangiferin and Mango Extracts
- HIV/AIDS oral health manifestations
- Tea Polyphenols and Effects
- Lung Cancer Treatments and Mutations
- Intestinal and Peritoneal Adhesions
- Congenital gastrointestinal and neural anomalies
- Pharmacogenetics and Drug Metabolism
Meharry Medical College
2018-2025
Vanderbilt University Medical Center
2024
Universidade do Porto
2022
University of Florida
2010-2020
University School of Nashville
2020
Qatar University
2016-2017
Bakhtar University
2016
BackgroundBenign prostatic hyperplasia is a common urological disease affecting older men worldwide, but comprehensive data about the global, regional, and national burden of benign its trends over time are scarce. As part Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2019, we estimated global in, prevalence of, disability-adjusted life-years (DALYs) due to hyperplasia, in 21 regions 204 countries territories from 2000 2019.MethodsThis study was conducted with GBD 2019...
Abstract The purpose of this study was to characterize the putative anxiolytic‐like activity fractions prepared from a hydroethanol extract Passiflora incarnata L. using elevated plus‐maze (EPM) in mice. were as published recently, yielding butanol, petroleum ether and chloroform fraction. From tested fractions, butanol fraction showed significant increases number open arm entries EPM concentrations 2.1 mg/kg 4.2 corresponding 150 300 original extract. highest found for doses 0.17 (10.0 ±...
The indolo[2,1-b]quinazoline alkaloid tryptanthrin was previously identified as a potent anti-inflammatory compound with unique pharmacological profile. It is inhibitor of cyclooxygenase-2, 5-lipooxygenase-catalyzed leukotriene synthesis, and nitric oxide production catalyzed by the inducible synthase. To characterize pharmacokinetic properties tryptanthrin, we performed pilot <i>in vivo</i> study in male Sprague-Dawley rats (2 mg/kg bw i. v.). Moreover, ability to cross blood-brain barrier...
Enteric neuronal cells play a vital role in gut motility humans and experimental rodent models. Patients with diabetes are more vulnerable to gastrointestinal dysfunction due enteric degeneration. In this study, we examined the mechanistic regulation of nuclear factor-erythroid 2-related factor 2 (Nrf2) hyperglycemia-induced cell apoptosis vitro by using adult mouse primary crest (pENCs). Our data show that hyperglycemia (HG) or inhibition Nrf2 induces elevating proinflammatory cytokines,...
Diabetic gastroparesis (DG) exhibits delayed gastric emptying (GE) due to impaired non-adrenergic, non-cholinergic (NANC) relaxation. These defects are loss or reduction of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) that causes reduced expression and/or dimerization neuronal nitric oxide synthase alpha (nNOSα) gene and function. We investigated the effect potent Nrf2 activators (cinnamaldehyde [CNM] & curcumin [CUR]) on GE in obesity-induced diabetic female mice. fed adult homozygous...
Porphyromonas gingivalis (Pg), a Gram-negative oral pathogen, promotes and accelerates periodontitis-associated gut disorders. Intestinal epithelial barrier dysfunction is crucial in the pathogenesis of intestinal systemic diseases. In this study, we sought to elucidate protective role cinnamaldehyde (CNM, an activator Nrf2) against P. (W83) Pg-derived lipopolysaccharide (Pg-LPS) induced via antioxidative mechanisms IEC-6 cells. (ATCC, CRL-1592) cells were pretreated with or without CNM (100...
Valerenic acid (VA), a sesquiterpenoid, is one of the major secondary bioactive metabolites Valeriana officinalis L. Until now in vivo studies on absorption, bioavailability, disposition, and metabolism VA are limited. We established validated an LC-MS/MS assay for determination rat plasma successfully used this method pharmacokinetic rats after intravenous (i. v.) oral administrations. The concentration-time data was analyzed by both non-compartmental compartmental approaches using...
An impaired nitrergic system and altered redox signaling contribute to gastric dysmotility in diabetics. Our earlier studies show that NF-E2-related factor 2 (NRF2) phase II antioxidant enzymes play a vital role neuronal nitric oxide synthase (nNOS) function. This study aims investigate whether supplementation of sepiapterin (SEP), precursor for tetrahydrobiopterin (BH4) (a cofactor NOS) via the salvage pathway, restores systems balance spontaneous diabetic (DB) female rats. Twelve-week DB...
Periodontal disease (PD) is known to be associated with endothelial dysfunction in patients coronary artery and/or cardiovascular disease. In our study, we sought explore the virulence of P. gingivalis (Pg) affecting glycogen synthase kinase 3 beta (GSK-3β)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/tetrahydrobiopterin (BH4 )/ nitric oxide (NOS) expression primary human aortic cells (pHAECs).pHAECs were infected for 48 hours Pg vitro using Human oxygen-Bacteria anaerobic coculture...
Gastroparesis (Gp) is a severe complication of diabetes mellitus (DM) observed predominantly in women. It characterized by abnormal gastric emptying (GE) without mechanical obstruction the stomach. Nitric oxide (NO) an inhibitory neurotransmitter produced neuronal nitric synthase (nNOS). plays critical role gastrointestinal (GI) motility and stomach emptying. Here, we wanted to demonstrate protective effects supplemental 17β-estradiol (E2) on NO-mediated function. We showed E2...
Diabetic gastroparesis (DG) is a clinical syndrome characterized by delayed gastric emptying (DGE). Loss of nuclear factor erythroid 2-related 2 (Nrf2) associated with reduced neuronal nitric oxide synthase-α (nNOSα)-mediated motility and DGE. Previous studies have shown that exclusion inactivation Nrf2 partly regulated glycogen synthase kinase 3β (GSK-3β). In the current study, molecular signaling GSK-3β-mediated activation its mechanistic role on DG were investigated in high-fat diet...
3,4-Dihydroxyphenylacetic acid (DOPAC) and 3-hydroxyphenylacetic (3-HPAA) are intestinal metabolites of the dietary flavonoid quercetin. DOPAC reportedly showed anxiolytic activity after i.p. administration in rats. The fate these consumption, pharmacological properties 3-HPAA body largely unknown. aim current study was to characterize pharmacokinetic intravenous bolus application UHPLC-MS/MS methods for quantification levels lithium heparin Sprague Dawley rat plasma were developed validated...
Gastroparesis (Gp) is a multifactorial condition commonly observed in females and characterized by delayed or rapid gastric emptying (GE). The role of ovarian hormones on GE the pathogenesis obesity induced type 2 diabetes mellitus (T2DM) completely unknown. aims our study are to investigate whether supplementation 17β-estradiol (E2) progesterone (P4) restores impaired nuclear factor erythroid 2-related (Nrf2, an oxidative stress-responsive transcription factor) nitric oxide (NO)-mediated...
Abstract Background Gastroparesis, a condition of abnormal gastric emptying, is most commonly observed in diabetic women. To date, the role ovarian hormones and/or hormone receptors on regulating nitrergic-mediated motility remains inconclusive. Aim The purpose this study to investigate whether sex hormones/their can attenuate altered Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), neuronal Nitric Oxide Synthase (nNOS) expression and nitrergic relaxation neuromuscular tissues exposed...