A5100413754- Lymphoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Gastric Cancer Management and Outcomes
- Advanced Radiotherapy Techniques
- Viral-associated cancers and disorders
- Esophageal Cancer Research and Treatment
- Acute Myeloid Leukemia Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gastrointestinal disorders and treatments
- Spinal Fractures and Fixation Techniques
- Gastrointestinal Tumor Research and Treatment
- Immune Cell Function and Interaction
- Head and Neck Cancer Studies
- Cancer Cells and Metastasis
- RNA and protein synthesis mechanisms
- Esophageal and GI Pathology
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Nitric Oxide and Endothelin Effects
- CNS Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Vascular Tumors and Angiosarcomas
- Colorectal Cancer Treatments and Studies
- Management of metastatic bone disease
- Mesenchymal stem cell research
National University Hospital
2016-2025
Chinese PLA General Hospital
2025
National University Health System
2015-2024
Chengdu University of Traditional Chinese Medicine
2023
Army Medical University
2019-2023
Southwest Hospital
2019-2023
Inner Mongolia People's Hospital
2023
Huazhong University of Science and Technology
2023
Peking University
2022
Hunan Normal University
2021
Printable scaffolds with adequate mechanical strength and stiffness are sought after to ensure viability of printed cells tissues. We report the first peptide bioinks-lysine-containing hexapeptides that self-assemble into stable, nanofibrous three-dimensional hydrogels unprecedented up 40 kPa. These biocompatible support culture human stem differentiation primary organotypic (gastrointestinal skin) structures for high-throughput screening, diagnosis, tissue engineering.
Seasonal influenza virus infections may lead to debilitating disease, and account for significant fatalities annually worldwide. Most of these deaths are attributed the complications secondary bacterial pneumonia. Evidence is accumulating support notion that neutrophil extracellular traps (NETs) harbor several antibacterial proteins, trap kill bacteria. We have previously demonstrated induction NETs contribute lung tissue injury in severe However, role pneumonia unclear. In this study, we...
Abstract Background Ultrasound-guided erector spine plane (ESP) block is widely used in perioperative analgesia for back, chest and abdominal surgery. The extent distribution of this remain controversial. This study was performed to assess the range an ultrasound-guided ESP block. Methods prospective observational volunteer consisted 12 healthy volunteers. All volunteers received spinae at left T5 transverse process using real-time ultrasound guidance. Measured cutaneous sensory loss area...
Most mammalian genes generate messenger RNAs with variable untranslated regions (UTRs) that are important post-transcriptional regulators. In cancer, shortening at 3' UTR ends via alternative polyadenylation can activate oncogenes. However, internal splicing remains poorly understood as studies have traditionally focused on protein-coding alterations. Here we systematically map the pan-cancer landscape of and present this in SpUR ( http://www.cbrc.kaust.edu.sa/spur/home/ ). is widespread,...
The application of periodontal ligament stem cells (PDLSCs) may be effective for regenerative therapy. As tissue potential negatively regulated by aging, whether aging and its microenvironment modify human PDLSCs remains a question. In this study, we compared the proliferation differentiation capacity obtained from young aged donors. Then, exposed to cell–conditioned medium (PLC-CM), were PLC-CM. Morphological appearance, colony-forming assay, cell cycle analysis, osteogenic adipogenic...
The aim of the present study was to investigate periodontitis-associated changes in number, proliferation and differentiation potential human periodontal ligament stem cells (PDLSCs). Cultures (PDLCs) were established from healthy donors with periodontitis. numbers cell characterized using flow cytometry. PDLSCs isolated PDLCs by immunomagnetic bead selection. Colony‑forming abilities, osteogenic adipogenic potential, gene expression cementoblast phenotype, alkaline phosphatase activity vivo...
Abstract Background Autoimmune responses mediated by cluster of differentiation 4 + T cells may contribute to the development chronic obstructive pulmonary disease ( COPD ). However, little is known about frequency peripheral blood h17 and regulatory regs) in C hinese patients with . This study aimed at determining circulating regs moderate severe , heavy smokers healthy controls HC Method The percentages ‐helper type h)17 were determined flow cytometry 32 33 35 smokers, 31 concentrations...
Obesity is an independent risk factor for severe outcome of influenza infection. Higher dietary fat consumption has been linked to greater morbidity and in mouse models. However, the extent generation neutrophil extracellular traps (NETs or NETosis) obese individuals during pneumonia hitherto unknown. This study investigated pulmonary NETs BALB/c mice fed with high-fat (HFD) low-fat (LFD) diets, course pneumonia. Clinical disease progression, histopathology, lung reactive oxygen species...
Alzheimer’s disease (AD) is a progressive neurodegenerative and the most common type of dementia. MicroRNAs (miRNAs) have been extensively studied in many diseases, including AD. To identify AD-specific differentially expressed miRNAs mRNAs, we used bioinformatics analysis to study candidate miRNA–mRNA pairs involved pathogenesis These miRNA–mRNAs may serve as promising biomarkers for early diagnosis or targeted therapy AD patients. In this study, based on mRNA miRNA expression profile data...
Abstract Globally, colorectal cancer (CRC) is the third most frequently occurring cancer. Progression on to an advanced metastatic malignancy (metCRC) often indicative of poor prognosis, as 5-year survival rates patients decline rapidly. Despite availability many systemic therapies for management metCRC, long-term efficacies these regimens are hindered by emergence treatment resistance due intratumoral and intertumoral heterogeneity. Furthermore, not all have associated biomarkers that can...
Colorectal cancer (CRC) ranks as the second leading cause of deaths globally. In recent years, short-read single-cell RNA sequencing (scRNA-seq) has been instrumental in deciphering tumor heterogeneities. However, these studies only enable gene-level quantification but neglect alterations transcript structures arising from alternative end processing or splicing. this study, we integrated short- and long-read scRNA-seq CRC samples to build an isoform-resolution transcriptomic atlas. We...
// Anandi Narayana Moorthy 1 , Prashant Rai 1,2 Huipeng Jiao Shi Wang 3 Kong Bing Tan Liang Qin 4 Hiroshi Watanabe Yongliang Zhang Narasaraju Teluguakula 5 and Vincent Tak Kwong Chow Department of Microbiology Immunology, Yong Loo Lin School Medicine, National University Singapore, Kent Ridge, Singapore 2 Infectious Diseases Interdisciplinary Research Group, Singapore-Massachusetts Institute Technology Alliance in Technology, Pathology, Hospital, Infection Control Prevention, Kurume Fukuoka,...
Multifunction bismuth-based nanoparticles with the ability to display diagnostic and therapeutic functions have drawn extensive attention as theranostic agents in radiation therapy imaging due their high atomic number, low toxicity, cost. Herein, we tried introduce multifunction bismuth gadolinium oxide (BiGdO3) a new agent for therapy, computed tomography (CT) magnetic resonance (MRI). After synthesis of BiGdO3 surface modifications them PEG, biocompatibility was evaluated by CCK-8 assay....
Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a rare and aggressive with molecular heterogeneity not well characterize. In this study, we performed next-generation sequencing analysis for number of DNA RNA samples from patients PT-DLBCL. identified ≥ 3 chromosomes copy variations (CNVs) microsatellite instability as prognostic biomarkers, rather than MYD88 mutations genetic subtypes. Remarkably, targeted RNA-seq in 195 revealed that TP53 40% variant allele frequency had...
Abstract PRL-3 (PTP4A3), a metastasis-associated phosphatase, is also upregulated in patients with acute myeloid leukemia (AML) and associated poor prognosis, but the underlying molecular mechanism unknown. Here, constitutive expression of human AML cells sustains leukemogenesis vitro vivo. Furthermore, phosphatase activity dependently upregulates LIN28B, stem cell reprogramming factor, which turn represses let-7 mRNA family, inducing cell–like transcriptional program. Notably, elevated...
Recently bismuth-based nanoparticles have drawn extensive attention as radiosensitizer in radiotherapy due to high atomic number, low toxicity, and cost. This study aims introduce the applicability of bismuth ferrite (BFO, BiFeO3) a new multifunctional theranostic agent for radiotherapy, magnetic resonance imaging (MRI), computed tomography (CT) well hyperthermia mediator. After evaluation BFO biocompatibility which were synthesized by conventional sol-gel method, we investigated dose...
Abstract Background The objective of this study was to investigate the relationship between clinical characteristics, as well dosimetric parameters, and risk treatment-related lymphopenia in esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (CRT). Materials Methods Clinical characteristics parameters were collected from 436 patients ESCC who received CRT 2010 through 2017. Absolute lymphocyte counts (ALCs) obtained before, during, 1 month after CRT. Grade 4...
Myxoma is the most common type of benign cardiac tumor in adults, and it has a strong tendency to embolize or metastasize distant organs. Patients with multiple brain metastases have rarely been seen clinics; hence, standard treatment protocols for multimyxoma metastasis not established. We present case 47-year-old female who had convulsions right hand repeated seizures. Computed tomography revealed sites her brain. Craniotomy was conducted remove sites. However, recurrent tumors unexpected...