A5075214218- Immune Cell Function and Interaction
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Hematopoietic Stem Cell Transplantation
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Liver physiology and pathology
- Immune cells in cancer
- Virus-based gene therapy research
- Trace Elements in Health
- Liver Disease Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- interferon and immune responses
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- HER2/EGFR in Cancer Research
Xinjiang Medical University
2019-2024
Tumor Hospital of Xinjiang Medical University
2019-2024
National University Cancer Institute, Singapore
2021-2024
National University of Singapore
2021-2024
Tongji Hospital
2021-2023
Huazhong University of Science and Technology
2021-2023
Central South University
2008-2023
Second Xiangya Hospital of Central South University
2021-2023
First Bethune Hospital of Jilin University
2022
University of Calgary
2020
Combination immunotherapy of cancer vaccines with immune checkpoint inhibitors (ICIs) represents a promising therapeutic strategy for immunosuppressed and cold tumors. However, this still faces challenges, including the limited efficacy immune-related adverse events associated systematic delivery ICIs. Herein, we demonstrate antitumor response induced by outer membrane vesicle from Akkermansia muciniphila (Akk-OMV), which exhibites favorable safety profile, highlighting potential application...
Abstract Acquired aplastic anemia (AA) is a potentially fatal bone marrow (BM) failure syndrome. IFN-γ–producing Th1 CD4+ T cells mediate the immune destruction of hematopoietic cells, and they are central to pathogenesis. However, molecular events that control development BM-destructive remain largely unknown. Ezh2 chromatin-modifying enzyme regulates multiple cellular processes primarily by silencing gene expression. We recently reported crucial for inflammatory cell responses after...
Colorectal cancer (CRC) ranks as the second leading cause of deaths globally. In recent years, short-read single-cell RNA sequencing (scRNA-seq) has been instrumental in deciphering tumor heterogeneities. However, these studies only enable gene-level quantification but neglect alterations transcript structures arising from alternative end processing or splicing. this study, we integrated short- and long-read scRNA-seq CRC samples to build an isoform-resolution transcriptomic atlas. We...
The anti-ErbB2 antibody trastuzumab has shown significant clinical benefits in metastatic breast cancer. However, resistance to is common. Heterodimerization between ErbB2 and other ErbBs may redundantly trigger cell proliferation signals confer resistance. Here, we developed a bispecific using pertuzumab, another ErbB2-specific humanized that binds distinct epitope from trastuzumab. This antibody, denoted as TPL, retained the full binding activities of both parental antibodies exhibited...
Graft-versus-host disease (GVHD) reflects an exaggerated inflammatory allogeneic T cell response in hosts receiving hematopoietic stem transplantation (HSCT). Inhibition of pan-Notch receptor signaling donor cells causes reduction GVHD. However, which Notch ligand(s) what APCs is important for priming graft-versus-host reaction remains unknown. We demonstrate that δ-like ligand-4 (Dll4) and Dll4-positive (Dll4(high)) dendritic (i-DCs) play roles eliciting responses. Host-type Dll4(high)...
Abstract Background Hepatocellular carcinoma (HCC) has a poor prognosis and new effective treatments are needed. SLC12A5 plays important roles in multiple complex pathological states is overexpressed variety of malignancies. However, the effects HCC have not been determined. Methods expression was assessed by immunostaining western blotting. A cell viability assay used to detect proliferation. Flow cytometry evaluate intracellular calcium concentration cycle. Ferroptosis detected...
Background: The mechanism of copper-induced cell death, which is called cuproptosis, has recently been clarified. However, the integrated role cuproptosis-related genes in hepatocellular carcinoma (HCC) and its relationship with immune characteristics are still completely unknown. Methods: In this study, expression, genetic, transcriptional regulation states 16 HCC were systematically investigated. An unsupervised clustering method was used to identify distinct expression patterns 370...
The anti-ErbB2 antibody trastuzumab has shown significant clinical benefits in ErbB2-overexpressing breast and gastric cancer, but resistance to the drug is common. Here, we investigated antitumor activity of combination SRC inhibitor saracatinib trastuzumab-resistant cancer. human cancer cell line NCI-N87 was treated with obtain NCI-N87R. NCI-N87R showed a marked increase ErbB signaling compared line. Our data demonstrated that plus much more potent than either agent alone reducing...
Abstract Background Hepatocellular carcinoma (HCC) is an inflammation-associated tumor involved in immune tolerance and evasion the microenvironment. Immunotherapy can enhance response of body, break tolerance, then recognize kill cells. The polarization homeostasis M1 M2 macrophages microenvironment (TME) occurrence development tumors has been considered a hot topic research. Programmed cell death ligand 1 (PD-L1) plays important role polarity TAM affects prognosis HCC patients as target...
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has an extremely poor prognosis. We aimed to determine latent relationships between TRIM36 regulation apoptosis Wnt/β-catenin pathway in HCC.Immunohistochemistry western blotting were used characterize aberrant expression HCC adjacent tissues. Clinical information was analyzed using Kaplan-Meier Cox methods. RNA-seq potential targets conducted detect TRIM36. Apoptosis assays cellular proliferation, invasion...
Liver fibrosis represent a major global health care burden. Data emerging from recent advances suggest TRPM8, member of the transient receptor potential (TRP) family ion channels, plays an essential role in various chronic inflammatory diseases. However, its liver remains unknown. Herein, we assessed effect TRPM8 fibrosis. The was evaluated using specimens obtained classic murine models fibrosis, namely wild-type (WT) and TRPM8-/- (KO) fibrotic mice after carbon tetrachloride (CCl4) or bile...
To investigate the factors predicting onset of major adverse cardiovascular events (MACEs) after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI) patients.
Abstract 3′UTR shortening in cancer has been shown to activate oncogenes, partly through the loss of microRNA-mediated repression. This suggests that many reported microRNA-oncogene target interactions may not be present cells. One most well-studied oncogenes is transcription factor MYC, which overexpressed more than half all cancers. MYC overexpression always accompanied by underlying genetic aberrations. In this study, we demonstrate shortened colorectal (CRC). Using unbiased computational...
Abnormal DNA methylation is one of the most general epigenetic modifications in hepatocellular carcinoma (HCC). Recent research showed that was a prognostic indicator all-cause HCC and nonviral HCC. However, whether methylation-driver genes could be used for predicting survival, probability hepatitis-positive remains unclear.In this study, (MDGs) were screened by joint analysis methylome transcriptome data 142 patients. Subsequently, risk score nomogram constructed. Finally, correlation...
Abstract Impairment of liver regeneration leads to severe morbidity in acute and chronic disease. Transient receptor potential melastain 8 (TRPM8) is involved a variety processes, including temperature sensing, ion homeostasis, cell proliferation. However, whether TRPM8 contributes still unclear. We assessed the effect mechanism hepatocyte proliferation vivo vitro. In this study, we found that deficiency impairs mice. Mechanistically, results revealed mitochondrial energy metabolism was...