A5102774445- Ferroptosis and cancer prognosis
- Ion Channels and Receptors
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- Cancer, Lipids, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Protein Tyrosine Phosphatases
- interferon and immune responses
- Dietary Effects on Health
- Cell death mechanisms and regulation
- Genetic factors in colorectal cancer
- Phytochemicals and Antioxidant Activities
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- PI3K/AKT/mTOR signaling in cancer
- Hedgehog Signaling Pathway Studies
- GABA and Rice Research
- Glutathione Transferases and Polymorphisms
- Single-cell and spatial transcriptomics
Second Xiangya Hospital of Central South University
2010-2024
Central South University
2012-2024
Shenzhen University
2022-2024
Shenzhen University Health Science Center
2021-2023
Xiangya Hospital Central South University
2008-2018
Osaka University
2003-2008
Graduate School USA
2005
Kyoto University
2003
Liver fibrosis is a common part of the pathological development many chronic liver diseases.
This study seeks to enhance the accuracy and efficiency of clinical diagnosis therapeutic decision-making in hepatocellular carcinoma (HCC), as well optimize assessment immunotherapy response.
Abstract Clinical studies have shown that oxaliplatin, a novel platinum derivative, is potent chemotherapeutic agent for colorectal cancer when combined with 5-fluorouracil and leucovorin. Although the toxic activity based on covalent adducts between DNA, its actual biological behavior mostly unknown. In an effort to explore mechanism of tumor susceptibility we examined cytotoxic effects oxaliplatin in cell lines reference p53 gene status. status did not clearly predict sensitivity wild-type...
Background: The mechanism of copper-induced cell death, which is called cuproptosis, has recently been clarified. However, the integrated role cuproptosis-related genes in hepatocellular carcinoma (HCC) and its relationship with immune characteristics are still completely unknown. Methods: In this study, expression, genetic, transcriptional regulation states 16 HCC were systematically investigated. An unsupervised clustering method was used to identify distinct expression patterns 370...
Anaplastic thyroid carcinoma is an aggressive neoplasm and resistant to all sorts of treatment due its rapid growth invasive potential. Peroxisome proliferator-activated receptor gamma (PPARgamma) a nuclear modulating variety biological properties, such as regulating adipogenesis, inhibition cancer cell proliferation or differentiation tumor cells. The purpose this study was evaluate the possibility for therapeutic effect PPARgamma ligands against anaplastic in vitro. Expressions PPARc gene...
The landscape of cellular plasticity and sources with relevant niche signals in hepatocellular carcinoma is still obscure. Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel, involved variety malignancies overexpressed (HCC). We have investigated the role TRPV1 HCC from different angles by various experimental techniques, such as vivo vitro experiments, bioinformatics analysis data genetic models induced diethylnitrosamine (DEN), mice samples human samples. find...
Liver fibrosis represent a major global health care burden. Data emerging from recent advances suggest TRPM8, member of the transient receptor potential (TRP) family ion channels, plays an essential role in various chronic inflammatory diseases. However, its liver remains unknown. Herein, we assessed effect TRPM8 fibrosis. The was evaluated using specimens obtained classic murine models fibrosis, namely wild-type (WT) and TRPM8-/- (KO) fibrotic mice after carbon tetrachloride (CCl4) or bile...
CDC25A is a cell cycle-activating phosphatase that promotes transition from the G1 to S phase. We previously reported overexpression of in human hepatocellular carcinoma (HCC) tissue samples was associated with poor prognosis. In this study, we attempted suppression HCC cells elucidate therapeutic potential approach. Administration antisense (AS) oligonucleotide resulted 25-50% inhibition growth at 48 h, G0-G1 arrest, and significant cancer invasion. To underlying mechanism inhibitory...
BACKGROUND:Almost all hepatic cancer cells have resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. c-FLIPL and RIP-1 are apoptotic negative regulatory factors. This study investigated the role of in cell TRAIL-induced MATERIAL AND METHODS:HepG2 were treated by TRAIL, siRNA, and/or BY11-7082. Cell viability was detected MTT assay. apoptosis tested flow cytometry. DISC component proteins, RIP-1, p-p65 measured Western blot. Caspase-8 caspase-3...
Abnormal DNA methylation is one of the most general epigenetic modifications in hepatocellular carcinoma (HCC). Recent research showed that was a prognostic indicator all-cause HCC and nonviral HCC. However, whether methylation-driver genes could be used for predicting survival, probability hepatitis-positive remains unclear.In this study, (MDGs) were screened by joint analysis methylome transcriptome data 142 patients. Subsequently, risk score nomogram constructed. Finally, correlation...
In our previous study, we reported that the cannabinoid receptors CB1 and CB2 are overexpressed in human hepatocellular carcinoma (HCC) tissues. Recently, antitumor potential of endogenous anandamide (AEA) has also been addressed. The present study was conducted to investigate anti-proliferative effects AEA HCC cells. cell line Huh7 used. Cell proliferation measured by MTT assay flow cytometry. Apoptotic analysis investigated TUNEL assay. Real-time PCR western blot were used analyze...
Numb, an endocytic adaptor, is a known cell fate determinant that participates in asymmetric division. The present study aimed to explore the potential roles of Numb hepatocarcinogenesis. expression was investigated hepatocellular carcinomas (HCC) with reverse transcription‑quantitative polymerase chain reaction and immunohistochemical examination; its association prognosis HCC patients analyzed. In addition, effects deletion on proliferation cells relevant molecules were evaluated Huh7...
Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers and fourth leading cause cancer-related deaths in world. Although treatment HCC has made great progress recent years, therapeutic effects on are still unsatisfactory due to difficulty early diagnosis, chemoresistance high recurrence rate post-surgery.In this study, we identified differentially expressed genes (DEGs) based four Gene Expression Omnibus (GEO) datasets (GSE45267, GSE98383, GSE101685 GSE112790) between...
Background: Transient receptor potential vanilloid 4 (TRPV4) is a member of the TRP channel family and involved in diverse physiological pathological processes. Accumulating evidence from vitro studies indicates that TRPV4 has role liver fibrosis, but its precise pathophysiological development this condition unclear. Exogenous interventions endogenous reactions should be considered. Methods: This study used mouse model carbon tetrachloride (CCl4)-induced fibrosis to investigate effects...