A5101675613- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Breast Cancer Treatment Studies
- Circular RNAs in diseases
- Ion Channels and Receptors
- Cancer Cells and Metastasis
- Hydrogen's biological and therapeutic effects
- RNA Research and Splicing
- Hedgehog Signaling Pathway Studies
- Cancer Risks and Factors
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Bacterial biofilms and quorum sensing
- Cardiovascular Health and Risk Factors
- Adrenal Hormones and Disorders
- Brain Metastases and Treatment
- Pituitary Gland Disorders and Treatments
- Genomics, phytochemicals, and oxidative stress
- Vascular Malformations Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Autophagy in Disease and Therapy
- Heat shock proteins research
Central South University
2014-2024
Second Xiangya Hospital of Central South University
2016-2024
Huazhong University of Science and Technology
2024
Beijing Tian Tan Hospital
2009-2023
Capital Medical University
2019-2023
Xiangya Hospital Central South University
2018-2019
Peking University
2016
Peking University First Hospital
2016
South Central Minzu University
2012
Background The prognostic effect of tumor infiltrating CD8+ cytotoxic lymphocytes (CTLs) in breast cancer is controversial. We analyzed the association between CTLs and survival untreated node-negative patients. Material Methods infiltrate was evaluated by immunostaining a cohort 332 patients with median follow-up 152 months. significance for disease-free (DFS) cancer-specific overall (OS) Kaplan-Meier analysis as well univariate multivariate Cox adjusted age at diagnosis, pT stage,...
Higher demand for nutrients including glucose is characteristic of cancer. "Starving cancer" has been pursued to curb tumor progression. An ,intriguing regime inhibit transporter GLUT1 in cancer cells. In addition, during progression, cells may suffer from insufficient supply. Yet can somehow tolerate starvation. Uncovering the underlying mechanisms shall not only shed insight into progression but also benefit therapy. TFE3 a transcription factor known activate autophagic genes....
// Kuijie Liu 1 , Hongliang Yao Sanlin Lei Li Xiong Haizhi Qi Ke Qian Jiqiang Peng Wang Hua Zhao Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China Correspondence to: Zhao, email: drzhaohua2012@163.com Keywords: miR-124, p63, feedback loop, cell growth, colorectal cancer Received: May 26, 2016 Accepted: February 20, 2017 Published: March 16, 2017 ABSTRACT Among the diverse...
The landscape of cellular plasticity and sources with relevant niche signals in hepatocellular carcinoma is still obscure. Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel, involved variety malignancies overexpressed (HCC). We have investigated the role TRPV1 HCC from different angles by various experimental techniques, such as vivo vitro experiments, bioinformatics analysis data genetic models induced diethylnitrosamine (DEN), mice samples human samples. find...
Numb, an endocytic adaptor, is a known cell fate determinant that participates in asymmetric division. The present study aimed to explore the potential roles of Numb hepatocarcinogenesis. expression was investigated hepatocellular carcinomas (HCC) with reverse transcription‑quantitative polymerase chain reaction and immunohistochemical examination; its association prognosis HCC patients analyzed. In addition, effects deletion on proliferation cells relevant molecules were evaluated Huh7...
Numerous miRNAs have been found to be abnormally expressed in hepatocellular carcinoma (HCC). However, clinical significance of miR-5010-3p HCC is not elucidated. This study aims explore the prognostic value and role HCC.
Cancer Dependency Map (CDM) genes comprise an extensive series of genome-scale RNAi-based loss-of-function tests; hence, it served as a method based on the CRISPR-Cas9 technique that could assist scientists in investigating potential gene functions. These CDM have role tumor cell survival and proliferation, suggesting they may be used new therapeutic targets for some malignant tumors. So far, there been less research involvement breast cancer, only tiny percentage studied. In this study,...
The predictive role of retinol-binding protein 4 (RBP4) in the adverse prognosis patients with stable coronary artery disease (CAD) has not been well-defined. We thus conducted this cohort study to investigate association between circulating RBP4 level and major cardiovascular events (MACEs) Chinese CAD.Patients CAD serum concentration measurement at admission July 2012 January 2015 were included. primary outcome was incident MACEs, which included acute syndrome, heart failure, stroke,...
Abstract Background In the context of breast cancer (BC), correlation between lymphocytes and clinical outcomes, along with treatment response, has garnered attention. Despite this, few investigations have delved into interplay among distinct peripheral blood lymphocyte (PBL) types, immune attributes, their implications within BC landscape. Methods The primary objective this study was to scrutinize baseline status PBL subsets in patients BC, track dynamic changes throughout treatment,...
More clinical evidence is needed regarding the relative priority of treatments for brain metastases (BMs) from EGFR/ALK-negative/unselected non-small cell lung cancer (NSCLC). PubMed, EMBASE, Web Science, Cochrane Library, and ClinicalTrials.gov databases were searched. Overall survival (OS), central nervous system progression-free (CNS-PFS), objective response rate (ORR) selected Bayesian network meta-analyses. We included 25 eligible randomized control trials (RCTs) involving 3,054...
Objective To explore the validity of graduated compression stockings (GCS) in prevention deep vein thrombosis (DVT) postoperative patients with central nervous system tumors. Methods Patients experimental group (n=100) were given GCS since first operative day until they can walk. control (n=80) did not apply treatment. Doppler studies lower extremities routinely obtained before and 3 days after surgery. Results Three developed DVT an incidence rate 3%; while 21 appeared 26% 1 patient...
Objective To detect the expression of calumenin (CALU) in human brain glioma samples, to explore its effect on patient′s outcome, and analyze related biological functions genes co-expressed with CALU. Methods A retrospective analysis was conducted CALU sequencing clinical data 288 patients positive mRNAseq_325 database Chinese Glioma Genome Atlas (CGGA). We analyzed effects levels survival different types patients. The multivariate Cox regression method used determine relevant factors...