A5100682328- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Glycosylation and Glycoproteins Research
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Microbial Applications in Construction Materials
- Tannin, Tannase and Anticancer Activities
- Acute Myeloid Leukemia Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Optical Imaging and Spectroscopy Techniques
- Medicinal Plant Pharmacodynamics Research
- Cancer Immunotherapy and Biomarkers
Guangzhou University of Chinese Medicine
2025
Xian Yang Central Hospital
2025
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2016-2024
Meizhou City People's Hospital
2024
Bengbu Medical College
2023-2024
Hangzhou Red Cross Hospital
2024
Wuhan University
2016-2023
Renmin Hospital of Wuhan University
2016-2023
Fudan University
2020-2023
Zhongshan Hospital
2020-2023
The lncRNA H19 and its mature product miR-675 have recently been shown to be upregulated promote the progression of gastric cancer. However, detailed function underlying molecular mechanism H19/miR-675 in carcinogenesis cancer remains unclear. In this study, we found that depended on enhance proliferation invasion AGS cells, expression was positively correlated with patients Subsequently, tumor-suppressor runt domain transcription factor 1 (RUNX1) confirmed a downstream molecule axis, since...
Curcumin, a major phytochemical in turmeric, inhibits the proliferation of many types solid cancer cells by enhancing p53 expression. However, long non‑coding RNA H19 directly activation and thus promotes gastric progression. The aim this study was to assess role curcumin-induced proliferative inhibition cancer. cell line SGC‑7901 treated with curcumin at different concentrations time points. effect on assessed using counting kit‑8 assays flow cytometry Ki67 staining. In addition, expression...
Abstract Accumulating evidence has indicated that long noncoding RNA NEAT1 exerts critical roles in cancers. So far, the detailed biological role and mechanisms of NEAT1, which are responsible for human gastric cancer (GC), still largely unknown. Here, we observed STAT3 expressions were significantly upregulated GC cells including BGC823, SGC‐7901, AGS, MGC803, MKN28 compared with normal epithelial GES‐1, while miR‐506 was downregulated. We inhibited inhibition able to repress growth,...
Helicobacter pylori (H. pylori) is listed as a class I carcinogen in human gastric cancer; however, the underlying mechanisms are poorly understood. In this study, we identified Protogenin (PRTG) was upregulated both cancer tissues and H. pylori-infected by analyzing dysregulated genes TCGA GEO databases. Importantly, PRTG predicted poor prognosis of patients integrative analysis revealed that served an oncogenic protein required for pylori-mediated tumorigenic activities vitro cellular vivo...
Abstract E- and P-selectin are cell surface lectins that mediate leukocyte-endothelial adhesion thereby participate in neutrophil recruitment into inflammatory sites. E-selectin can be induced on endothelial cells by various activators, including TNF-α, IL-1β, PMA. Induction of is blocked pretreatment with IL-4 or TGF-β, both which have antiinflammatory properties vivo. In addition to its well-known proinflammatory activities, IFN-γ also has effects vivo, one inhibition recruitment. To...
Abstract The role of NETosis and its related molecules remains unclear in gastric cancer. data used this study was directly downloaded from the Cancer Genome Atlas (TCGA) database. All analysis plots are completed R software using diverse packages. In our study, we collected list NETosis‐related genes previous publications. Based on expression profile cancer patients TCGA database, identified significantly correlated with survival. Then, CLEC6A, BST1 TLR7 were through LASSO regression...
Helicobacter pylori infection is recognized as a major risk factor for gastric cancer (GC) progression; however, the underlying molecular mechanisms have remained to be fully elucidated.qPCR and Western blot were used detect mRNA level relative protein expression. Wound healing assay transwell determine migration invasion of cells. Calcium imaging was calcium signaling in Luciferase reporter immunohistochemistry performed.In present study, it demonstrated that H. GC closely associated with...
To determine the role of endothelial cell adhesion molecules E- and P-selectin in development severity adjuvant-induced arthritis (AIA) rat.Lewis rats were immunized subcutaneously with Mycobacterium butyricum (Mb), blocking monoclonal antibodies (mAb) to rat administered. Clinical score, radiolabeled (51Cr 111In) blood polymorphonuclear leukocyte (PMN) monocyte migration joints, histologic features monitored.When mAb treatment was started on day 5 postimmunization Mb (preclinical stage),...
Neuroblastoma (NB), a common solid tumour in young children originating from the sympathetic nervous system during embryonic development, poses challenges despite therapeutic advances like high-dose chemotherapy and immunotherapy. Some survivors still grapple with severe side effects drug resistance. The role of lncRNA NUTM2A-AS1 has been explored various cancers, but its function drug-resistant NB progression is unclear. Our study found that expression cisplatin-resistant cells increased...
Alterations in glycosylation regulate fundamental molecular and cellular processes of cancer, serving as important biomarkers therapeutic targets. However, the potential association regulatory mechanisms E6 oncoprotein on cervical cancer cells are still unclear. Here, we evaluated glycomic changes via using Lectin microarray determined corresponding enzymes associated with endogenous high-risk HPV16 expression cells. α-2,6 sialic acids glycosyltransferase ST6GAL1 were significantly increased...
Despite the increasing application of laparoscopic hepatectomy (LH) for hepatocellular carcinoma (HCC), left hemihepatectomy (LLH) remains a relatively rare surgery and comparison perioperative oncological outcomes between LLH open (OLH) is lacking.A total 276 HCC patients who underwent either or OLH January 2008 November 2019 were enrolled in this retrospective observational study 1:2 propensity score matching (PSM) was performed groups.Patients group had smaller tumor size (P=0.001)...
Abstract Although starvation stress can alter the homeostasis of mitochondria and promote autophagy, there is still a lack research focusing on connection between them. In this study, we found that, accompanied by upregulation autophagy flux, membrane mitochondrial potential (MMP), content reactive oxygen species (ROS), production ATP, copy number DNA (mt‐DNA) were changed when limiting amino acids supply. We screened analyzed altered genes related to under verified that expression...