A5102936713- Acute Ischemic Stroke Management
- Cancer-related molecular mechanisms research
- Colorectal Cancer Screening and Detection
- Clinical practice guidelines implementation
- Neurological Disease Mechanisms and Treatments
- Cardiovascular and Diving-Related Complications
- Neurological Disorders and Treatments
- Circular RNAs in diseases
- High Altitude and Hypoxia
- Machine Learning in Healthcare
- Anorectal Disease Treatments and Outcomes
- GABA and Rice Research
- Child Abuse and Trauma
- Migration, Health and Trauma
- RNA modifications and cancer
- Cannabis and Cannabinoid Research
- Cardiovascular Health and Risk Factors
- Colorectal Cancer Surgical Treatments
- MicroRNA in disease regulation
- Diet, Metabolism, and Disease
- Extracellular vesicles in disease
- Homelessness and Social Issues
Fourth Hospital of Changsha
2020-2022
Hunan Normal University
2020-2022
Central South University
2012-2021
Abstract Accumulating evidence has suggested that extracellular vesicles (EVs) play a crucial role in lung cancer treatment. Thus, we aimed to investigate the modulatory of bone marrow mesenchymal stem cell (BMSC)‐EV‐derived let‐7i and their molecular mechanism progression. Microarray‐based analysis was applied predict cancer‐related miRNAs downstream genes. RT‐qPCR Western blot analyses were conducted determine Let‐7i, lysine demethylase 3A (KDM3A), doublecortin‐like kinase 1 (DCLK1) FXYD...
Objective: This research probed into the molecular mechanisms of long non-coding RNA (lncRNA) VPS9D1 Antisense 1 (VPS9D1-AS1) in lung adenocarcinoma (LUAD). Methods: lncRNA expression level was evaluated bioinformatically, and its downstream miRNA/mRNA regulatory axis predicted by bioinformatics methods as well. qRT-PCR used to measure VPS9D1-AS1, miRNA-30a-5p, kinesin family member 11 (KIF11) expression. Western blot performed KIF11 protein Proliferation, migration, invasion LUAD cells were...
In our previous study, we reported that the cannabinoid receptors CB1 and CB2 are overexpressed in human hepatocellular carcinoma (HCC) tissues. Recently, antitumor potential of endogenous anandamide (AEA) has also been addressed. The present study was conducted to investigate anti-proliferative effects AEA HCC cells. cell line Huh7 used. Cell proliferation measured by MTT assay flow cytometry. Apoptotic analysis investigated TUNEL assay. Real-time PCR western blot were used analyze...
Background and Aims . To investigate the clinical effect of preservation or nonpreservation left colic artery (LCA) in total mesorectal excision (TME) under laparoscopy. Methods The words, like “rectal cancer,” “left colonic artery,” “laparoscopy,” were used as retrieval terms, keyword method was adopted. period set from January 1, 2013, to June 2018. We searched databases including PubMed, Web Science, China National Knowledge Infrastructure (CNKI) collect randomized controlled trials which...
Background The purpose of this study is to investigate and analyze the prevalence influencing factors stroke in hypertensive patients aged 60 above Jiading District, Shanghai. Methods population-based included 18,724 screened people with hypertension (age ≥ years, 48.7% women). From 2016 2019, data on demographics, potential health status were collected through face-to-face interviews, physical examinations, laboratory tests. Logistic multivariate logistic regression model was used...
The value of identifying and targeting population demographics at high risk stroke based on patient-reported outcomes (PROs) with electronic health records (EHRs) in Shanghai is largely undiscovered.To test the hypothesis that establishing an evidence-based support system composed PROs integrated EHRs could be effective individuals suffering from stroke.The patients included this study joined hypertensive patient management 2014 to 2018. We merged Hypertension Patients Management Database...
Abstract Background The value of targeting people with a high risk stroke based on electronic health records (EHRs) in Shanghai is largely undiscovered.Aim To test the hypothesis that EHRs might be developed into an evidence-based support system to identify who are at stroke.Methods We performed screen analysis utilizing target population factors, such as hypertension, diabetes mellitus, obesity, smoking and physical inactivity. calculated distribution each factor combinations...
Objective To investigate the prevalence of obstructive sleep apnea-hypopnea syndrome (OSAHS) in pilots and to provide reference on prevention cure OSAHS pilots. Methods Two hundred thirty-six were randomly picked asked fill out a questionnaire about Epworth sleepiness scale (ESS) score. Their age, smoking drinking habit gathered. neck circumference, height, body weight mass index (BMI) also measured. The monitored by nocturnal oxygen saturation, apnea hypopnea (AHI) other...