Background Proteinuria is a risk factor for cardiovascular events, but its prognostic value sudden cardiac arrest (SCA) in young individuals remains unproven. We aimed to evaluate whether proteinuria people associated with an increased of SCA. Methods and Results Individuals aged between 20 39 years who underwent health screening 2009 2012 South Korea were included (n=6 891 400). Urine protein was measured using the spot urine dipstick method. Main outcome SCA identified by International...

Data regarding health behavior-related factors and systolic or diastolic blood pressure to evaluate the association between kidney cancer are lacking. Using nationally representative data from Korean National Health Insurance System, 9 746 445 participants without January 1, 2006 December 31, 2009 were followed up until 2017 obtain incidence. Participants categorized, according pressure, as normal (<120/80 mm Hg), elevated (120-129/<80 hypertensive (≥130/80 Hg) with antihypertensive...

Importance Depression is among the most common comorbidities in rheumatoid arthritis (RA). There a lack of data regarding association RA seropositivity and biologic agents with depression risk individuals RA. Objective To investigate following diagnosis patients South Korea. Design, Setting, Participants This retrospective cohort study included 38 487 comparison group 192 435 matched 1:5 for age, sex, index date. Data were from Korean National Health Insurance Service database. enrolled 2010...

Objective Specific differences in cancer risk have been observed between systemic lupus erythematosus patients and the general population. Although meta-analyses estimated incidence patients, results inconclusive. Hence, we aimed to assess malignancy compared Methods Systemic ( n = 21,016; mean age 41.67 ± 13.14 years; female 90.22%) were selected from Korean National Health Insurance Service database 2008 2014. Age- sex-matched controls randomly sampled a 5:1 ratio 105,080). Results During...

Abstract Background Patients with diabetes mellitus have an increased risk of incident atrial fibrillation (AF). The effect accumulated hypertension burden is a less well-known modifiable factor. We explored the relationship between and AF in these patients. Methods evaluated data for 526,384 patients who underwent three consecutive health examinations, 2009 2012, from Korean National Health Insurance Service. Hypertension was calculated by assigning points to each stage examination: 1...

Abstract Background The long‐term effects of cholecystectomy on mortality and cardiovascular disease (CVD) in patients with diabetes have not been evaluated. In the present study, we investigated longitudinal CVD a population‐based cohort type 2 (T2D). Methods total, 216 930 national health examination participants T2D, including 19 258 cholecystectomy, were followed up for median 7.9 years. adjusted hazard ratios (aHRs) calculated all‐cause (myocardial infarction or ischemic stroke) group...

We investigated the effect of differential blood pressure (BP) levels on future end-stage renal disease (ESRD) in patients with type 2 diabetes mellitus (T2DM) and established coronary artery a previous record percutaneous intervention (PCI). Using health check-up data from Korean National Health Insurance Service (2015-2016), we analyzed 80,187 T2DM history PCI. Patients were categorized by BP measured: systolic < 120, 120-129 (reference), 130-139, 140-149, ≥150 mmHg; diastolic 70, 70-79...

Several studies have reported that dementia has a high prevalence in end-stage kidney disease (ESKD) patients. However, the relationship between physical activity (PA) and risk of not been elucidated for hemodialysis A total 11,724 patients aged ≥40 years who started 2012 2017 were identified from Korean National Health Insurance Service database. Individuals with PA defined as meeting following criteria: 1) 1 or more days per week vigorous at least 20 minutes day 2) moderate-intensity 30...

Background/Objectives: Given the rising incidence of early-onset endometrial cancer diagnosed before age 50 years, this study examined whether non-alcoholic fatty liver disease (NAFLD) served as an independent risk factor for cancer, irrespective obesity status. Methods: This nationwide cohort included 2,311,949 Korean women aged 20–39 years who underwent health screenings from 2009 to 2012. NAFLD severity was classified based on index: none (&lt;30), moderate (30–59), and severe (≥60)....

This study aimed to assess whether markers of diabetes severity could serve as predictors for foot amputation risk among patients with type 2 mellitus. We analyzed data from the nationally representative Korean National Health Insurance System database, tracking 2,544,077 mellitus who participated in routine health check-ups between 2009 and 2012, followup extending through end 2018. The parameters used define score encompassed duration, insulin usage, number oral glucose-lowering...

Background Hypertension among young adults is common. However, the effect of isolated systolic hypertension (ISH), diastolic (IDH), or and (SDH) on chronic kidney disease (CKD) development unknown. Methods Results From a nationwide health screening database, we included 3 030 884 participants aged 20 to 39 years who were not taking antihypertensives at baseline examination in 2009 2010. Participants categorized as having normal blood pressure (BP), elevated BP, stage 1 IDH, ISH, SDH, 2 SDH....

Recent hypertension guidelines have recommended lower blood pressure (BP) targets in high-risk patients. However, there are no specific based on age or systolic and diastolic (SBP DBP, respectively). We aimed to assess the effects of age-related BP development end-stage renal disease (ESRD) patients with diabetes.A total 2 563 870 diabetes aged >20 years were selected from Korean National Health Screening Program 2009 2012 followed up until end 2019. Participants categorized into groups,...

Abstract Sudden cardiac arrest (SCA) is a medical disaster for both the victim and society. Despite intrinsic limitations in management of SCA, primary prevention has been overlooked risk factors SCA are not fully understood. We aimed to evaluate whether hypertension diabetes mellitus (DM), including pre-hypertension impaired fasting glucose (IFG), associated with increased SCA. performed nationwide population-based analysis using Korean National Health Insurance Service. People who...

Despite the risk of incident chronic kidney disease among patients with rheumatoid arthritis (RA), association RA and end-stage renal (ESRD) has not been clearly elucidated. We aimed to investigate ESRD.A total 929,982 subjects (n = 154,997) or without 774,985) from National Health Insurance Service (NHIS) database in Koreas (corresponding period between 2009 2017) were retrospectively analyzed. was defined by International Classification Diseases, 10th Revision, Clinical Modification...

In this study based on a large nationally representative sample of Korean adults, we investigated the potential associations body mass index (BMI) and waist circumference (WC) with mortality in patients undergoing hemodialysis. We obtained data 18,699 participants &gt;20 years age who were followed up for 4 whom BMI WC information available, using dataset from National Health Insurance System. Patients stratified into five levels by their baseline six (5-cm increments). A total 4975 deaths...

We analyzed data from the Korean National Health Insurance Service (NHIS) to investigate whether smoking increases risk of end-stage kidney disease (ESKD). This retrospective nationwide population-based cohort study included 23,232,091 participants who underwent at least one health examination between 2009 and 2012. Smoking status was recorded baseline. The incidence ESKD identified via ICD-10 codes special medical aid database till December 2016. A Cox proportional-hazards model with...

Abstract Depression is associated with impaired quality of life and increased morbidity mortality in end-stage kidney disease (ESKD) patients transplantation (KT) recipients. incidence after KT unclear. We compared depression among recipients, ESKD patients, healthy controls (HCs). analyzed a nationwide health insurance database South Korea identified who underwent during 2007–2015. Participants were matched for age, sex, inclusion year. further hypertension diabetes mellitus history. The...

Abstract Background Body weight variability (BWV) negatively affects the incidence and outcomes of various diseases, but nature association between BWV depression remains unclear. In this study, we aimed to test hypothesis that is associated with risk new-onset depression. Methods Data from a nationwide population-based cohort in Korean National Health Insurance Service database were analyzed for 6 598 570 adults no history reports at least three health examinations. was estimated using...

The prevalence of metabolic syndrome (MetS) and kidney cancer is increasing, but studies on the effects MetS its components development have had ambiguous results. Overall, 7,613,865 patients from Korean National Health Insurance System were analyzed followed up until 2017. Patients with 3 necessary five diagnosed MetS. divided into subgroups according to two consecutive physical examinations conducted every years. Cox proportional hazard regression model was used survey independent...

Abstract Background While cancer patients are at an increased risk of cardiovascular disease (CVD), the role modifiable factors remains poorly understood. This study investigated whether lifestyle modifications affect CVD development in gastric who undergo surgery. Methods Using data from Korean National Health Insurance Service (NHIS), underwent surgery 2010 to 2017 were identified. Lifestyle behaviours, surveyed within 2 years before and after analysed. Incident CVD, defined as a composite...

Abstract Background The potential preventive effect of fenofibrate on lower extremity amputation (LEA) and peripheral arterial disease (PAD) in patients with type 2 diabetes (T2D) is not fully elucidated. Methods We selected adult ≥ 20 years age T2D from the Korean National Health Insurance Service Database (2009–2012). users were matched a 1:4 ratio non-users using propensity scores (PS). outcome variables composite LEA PAD individual components. risks outcomes implemented as hazard (HR)...

Limited data are available on the adverse effects of new-onset diabetes after transplantation (NODAT) in solid organ (TPL) other than kidney. This study aimed to identify risk complications associated with NODAT recipients kidney, liver, or heart TPL.

Psoriasis, a chronic inflammatory dermatosis, has been associated with kidney disease or end-stage renal disease. However, the association of changes amount proteinuria psoriasis development not evaluated. Using Korean National Health Screening database, we assessed until 2018 in 6,576,851 Koreans who underwent health examinations 2009 and 2011. Psoriasis was defined using International Classification Diseases, 10th revision (ICD-10) code L40. The risk evaluated according to change (never...