A5068473792- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Voice and Speech Disorders
- Botulinum Toxin and Related Neurological Disorders
- Cannabis and Cannabinoid Research
- Neurobiology of Language and Bilingualism
- Balance, Gait, and Falls Prevention
- Lysosomal Storage Disorders Research
- Nerve Injury and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Trigeminal Neuralgia and Treatments
- Migraine and Headache Studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Ginkgo biloba and Cashew Applications
- Obsessive-Compulsive Spectrum Disorders
- Olfactory and Sensory Function Studies
- Dementia and Cognitive Impairment Research
- Systemic Lupus Erythematosus Research
- Banana Cultivation and Research
- Sympathectomy and Hyperhidrosis Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Creativity in Education and Neuroscience
- Stuttering Research and Treatment
Tel Aviv Sourasky Medical Center
2018-2025
Tel Aviv University
2014-2025
University Health Network
2019
Toronto Western Hospital
2017-2018
University of Toronto
2017-2018
The Neurological Institute
2017
Sheba Medical Center
2009-2015
Objective Creative thinking requires a combination of originality, flexibility, and usefulness. Several reports described enhanced artistic creativity in Parkinson disease (PD) patients treated with dopaminergic agents. We aimed to examine PD patients' ability perform tasks compared healthy controls verify whether is related an impulse control disorder (ICD) as complication therapy. Methods Right‐handed dopamine agonists and/or levodopa, age‐ education‐ matched neurologically were assessed...
Background: Botulinum Toxin type A (BonTA) is the preferred treatment for Cervical Dystonia (CD). However, success rate often suboptimal. One of reasons failure in accuracy injections. Some physicians rely on Anatomical Landmarks (AL) injections, while others use either Ultrasound (US) or Electromyography guidance (EMGg) to improve accuracy. Methods: This retrospective two-center study compared therapeutic outcomes AL-based and EMGg injections with USg Demographic clinical assessments...
Clinical monitoring of patients with Parkinson's disease (PD) for cognitive decline is an important element care. The Montreal Cognitive Assessment (MoCA) has been proposed to be a sensitive tool assessing impairment in PD. aim our study was compare the responsiveness MoCA cognition Mini Mental State Examination (MMSE) and Scales Outcomes disease-cognition (SCOPA-Cog).PD without dementia were enrolled at 6 North American movement disorders centers between 2008 2011. Participants received...
We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, 26 controls. In distinguishing iPD, mean sensitivity was 95.4% (SD 17.8%) specificity 89.6% 26.5%). Voice features for controls much less discriminatory. Vocal...
ABSTRACT Background Heart rate variability is reduced in idiopathic PD, indicating cardiac autonomic dysfunction likely resulting from peripheral synucleinopathy. Little known about heart leucine‐rich repeat kinase 2‐associated PD. Objectives This study investigated LRRK2 ‐associated Methods Resting electrocardiograms were obtained 20 individuals with 37 nonmanifesting carriers, 48 related noncarriers, 26 PD patients, and 32 controls. Linear regression modelling compared time frequency...
Sporadic progressive ataxia and palatal tremor is a rare syndrome characterized by mid- to late-adult-onset symptomatic slowly cerebellar ataxia. To date, there has been only one autopsy report, which described novel 4-repeat tauopathy with hypertrophic olivary degeneration tau-positive inclusions in neurons dystrophic neuritic processes termed glomeruloid bodies. We report on 2 additional cases.Sections from selected paraffin-embedded brain regions were stained hematoxylin eosin/Luxol fast...
Huntington's disease (HD) is a neurodegenerative characterized by increasing dysphagia as the progresses. Specific characteristics of HD are not well defined.To characterize swallowing disturbances patients, to evaluate feasibility Fiberoptic Endoscopic Evaluation Swallowing (FEES) in assessing and discern relation between FEES findings patients' self-report on symptoms related quality life (SWAL-QOL).A retrospective case series tertiary referral center. All recruited patients underwent Bed...
Objective. The goal of this study is to decode the electrical activity single neurons in human subthalamic nucleus (STN) infer speech features that a person articulated, heard or imagined. We also aim evaluate amount required for high accuracy decoding suitable real-life brain-machine interfaces (BMI).Approach. intraoperatively recorded single-neuron STN 21 neurosurgical patients with Parkinson's disease undergoing implantation deep brain stimulator while produced, perceived imagined five...
ABSTRACT Objectives The objective of this study was to determine phenotypic features that differentiate nonparkinsonian first‐degree relatives PD leucine‐rich repeat kinase 2 ( LRRK2 ) G2019S multiplex families, regardless carrier status, from healthy controls because individuals in families seem share a propensity present neurological features. Methods We included familial cases and unrelated participating established family cohorts. Study participants underwent neurologic assessment...
While cannabis-based medicine is being commonly used in patients with movement disorders, there a scarcity of publications regarding the effect cannabis on dystonia. We aimed to describe medical use dystonia and related pain.We employed structured interview obtain data treatment regimen, perception effectiveness side profile. Eligible participants were diagnosed from disorders unit at Tel-Aviv Medical Center who had licensed between January 2019 2021.Twenty-three subjects interviewed (11...
Background:With recent advances in the search for disease-modifying therapies Parkinson's disease (PD) importance of identifying prodromal markers becomes greater. Non-manifesting LRRK2 mutation carriers (NMC) are at risk developing PD, and provide a population which to identify poss ible markers. Objective:The aim this study was test hypothesis that NMC have differences daily activity, fragmentation sleep, arm swing asymmetry, movement variability during walking, detectable by actigraphy,...
BACKGROUND AND OBJECTIVES: The human thalamus is known, from stimulation studies and functional imaging, to participate in high-level language tasks. goal of this study find whether how speech features, particular, vowel phonemes, are encoded the neuronal activity thalamus, specifically left ventralis intermediate nucleus (Vim), during production, perception, imagery. METHODS: In cross-sectional study, we intraoperatively recorded single neuron Vim eight neurosurgical patients with...
<b><i>Background:</i></b> Worldwide prevalence estimates of Huntington disease (HD) vary widely, with no reliable information regarding the Jewish population in Israel. <b><i>Methods:</i></b> This specialized tertiary single-center cross-sectional study assessed clinical, cognitive, and demographic characteristics 84 HD patients who were treated at Movement Disorder Unit Tel Aviv Medical Center, <b><i>Results:</i></b>...
Introduction: Onabotulinum toxin A is an effective treatment for a variety of movement disorders; yet, results efficacy in patients with medically-resistant tic disorders are insufficient.We aimed to assess the ocular tics observational study.Methods: Patients tics, regularly treated injections at our clinic, were enrolled 2 visits, one which was baseline assessment and single injection session second -a follow-up visit month after evaluation outcome.The tools consisted 10-minute videotape...
Objectives Real-world data were used to describe first antiparkinsonian drug (FAPD) prescription patterns among Parkinson disease (PD) patients and evaluate duration until levodopa ( l -DOPA) treatment death, as related FAPD, by age group. Methods The community-based cohort (2000–2012) included 6243 patients, members of an Israeli Health Maintenance Organizations. Time from FAPD purchase 2 end points -DOPA death) was calculated. Cox regressions estimate adjusted heart rate (HR) either point...
We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, 26 controls. In distinguishing iPD, mean sensitivity was 95.4% (SD 17.8%) specificity 89.6% 26.5%). Voice features for controls much less discriminatory. Vocal...
<b><i>Background:</i></b> The Unified Dyskinesia Rating Scale (UDysRS) is a well-established tool for producing comprehensive assessments of severity and disability associated with dyskinesia in patients Parkinson’s disease (PD). scale was originally developed English, broad international effort has been undertaken to develop validate versions additional languages. Our aim the Hebrew version UDysRS. <b><i>Methods:</i></b> We translated UDysRS...