A5100705071- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Neurobiology and Insect Physiology Research
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Tyrosine Phosphatases
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Autism Spectrum Disorder Research
- Vestibular and auditory disorders
- Stress Responses and Cortisol
- Intracranial Aneurysms: Treatment and Complications
- Semiconductor materials and devices
- Neurofibromatosis and Schwannoma Cases
- Epigenetics and DNA Methylation
- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Moyamoya disease diagnosis and treatment
- RNA modifications and cancer
- Hearing, Cochlea, Tinnitus, Genetics
Seoul National University
2016-2025
Sejong University
2025
Seoul National University Hospital
1996-2024
Boramae Medical Center
2005-2024
University of Ulsan
2009-2024
Seoul Metropolitan Government
2016-2024
New Generation University College
2016-2024
Institute of Immunology
2024
National University College
2024
Ulsan College
2013-2024
We present the first Korean individual genome sequence (SJK) and analysis results. The diploid of a male was sequenced to 28.95-fold redundancy using Illumina paired-end sequencing method. SJK covered 99.9% NCBI human reference genome. identified 420,083 novel single nucleotide polymorphisms (SNPs) that are not in dbSNP database. Despite close similarity, significant differences were observed between Chinese (YH), only other Asian available, SJK: (1) 39.87% (1,371,239 out 3,439,107) SNPs...
Transgenic overexpression of NMDA NR2B receptors in forebrain regions increased behavioral responses to persistent inflammatory pain. However, it is not known whether inflammation leads the upregulation these regions. Here, we show that peripheral expression and receptor-mediated synaptic currents anterior cingulate cortex (ACC). In freely moving mice, increase after contributed enhanced ACC. Inhibition ACC selectively reduced sensitization related inflammation. Our results demonstrate...
Adeno-associated virus (AAV) vectors can deliver transgenes to diverse cell types and are therefore useful for basic research gene therapy. Although AAV has many advantages over other viral vectors, its relatively small packaging capacity limits use delivering large genes. The available transgene size is further limited by the existence of additional elements in expression cassette without which level becomes much lower. By using alternative combinations shorter elements, we generated a...
Ca<sup>2+</sup>/calmodulin (CaM)-dependent protein kinase II (CaMKII) "autonomy" (T286-autophosphorylation-induced Ca<sup>2+</sup>-independent activity) is required for long-term potentiation (LTP) and learning memory, as demonstrated by CaMKII T286A mutant mice. The >20-year-old hypothesis that stimulation LTP induction, while autonomy maintenance was recently supported using the cell-penetrating fusion-peptide inhibitor antCN27. However, we demonstrate here ant/penetratin fusion to CN27...
Although the role of CCR5 in immunity and HIV infection has been studied widely, its neuronal plasticity, learning memory is not understood. Here, we report that decreasing function increases MAPK/CREB signaling, long-term potentiation (LTP), hippocampus-dependent mice, while overexpression caused deficits. Decreasing mouse barrel cortex also resulted enhanced spike timing dependent plasticity consequently, dramatically accelerated experience-dependent plasticity. These results suggest a...
MicroRNAs (miRNAs) are small, noncoding RNAs that posttranscriptionally regulate gene expression in many tissues. Although a number of brain-enriched miRNAs have been identified, only few specific revealed as critical regulators synaptic plasticity, learning, and memory. miR-9-5p/3p known to development their changes implicated several neurological disorders, yet role mature neurons mice is largely unknown. Here, we report inhibition miR-9-3p, but not miR-9-5p, impaired hippocampal long-term...
Although medial prefrontal cortex (mPFC) is known to play important roles in social behaviors, how early experiences affect the mPFC and its subcortical circuit remains unclear. We report that mice singly housed (SH) for 8 weeks after weaning show a recognition deficit, even 4 of resocialization. In SH mice, infralimbic (IL) neurons projecting shell region nucleus accumbens (NAcSh) decreased excitability compared with group-housed (GH) mice. NAcSh-projecting IL are activated when GH...
Wernicke encephalopathy (WE) is a metabolic disorder of the central nervous system resulting from vitamin B(1) deficiency. The exact mechanisms underlying pathogenesis lesions in WE are not completely understood. Vitamin B1 deficiency associated with intracellular and extracellular edema by glutamate(N-methyl-D-aspartate) receptor-mediated excitotoxicity. Conventional magnetic resonance imaging (MRI) cannot differentiate types edema. Diffusion-weighted (DWI) has been reported to detect early...
Control of Ca 2+ flux between the cytosol and intracellular stores is essential for maintaining normal cellular function. It has been well established in both neuronal non-neuronal cells that stromal interaction molecule 1 (STIM1) initiates regulates refilling into ER. Here, we describe a novel, additional role STIM1, regulation free cytosolic , consequent control spike firing neurons. Among central neurons, cerebellar Purkinje neurons express highest level they fire continuously absence...
Multiple brain regions are engaged in classical fear conditioning. Despite evidence for cerebellar involvement conditioning, the mechanisms by which outputs modulate learning and memory remain unclear. We identify a population of deep nucleus (DCN) neurons with monosynaptic glutamatergic projections to lateral parabrachial (lPBN) (DCN→lPBN neurons) mice. While optogenetic suppression DCN→lPBN impairs auditory memory, activation elicits freezing behavior only after Moreover, conditioning...
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental associated with impaired social behavior and communication, repetitive behaviors, restricted interests. In addition to genetic factors, environmental factors such as prenatal drug exposure contribute the development of ASD. However, how those induce behavioral deficits in adult stage not clear. To elucidate ASD pathogenesis at molecular level, we performed high-resolution mass spectrometry-based quantitative proteomic analysis...
A monolithic realization of a switched-capacitor amplifier is reported. It has op-amp offset voltage cancellation without requiring the output to slew ground each time reset. The very insensitive low gain. also clock-feedthrough cancellation. Finally, it can be used as differential with both inputs being sampled at same instance.