A5009350257- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Pluripotent Stem Cells Research
- Anesthesia and Neurotoxicity Research
- Neuroscience of respiration and sleep
- Virus-based gene therapy research
- Plant Molecular Biology Research
- Cognitive and developmental aspects of mathematical skills
- Technology Assessment and Management
- Cancer, Stress, Anesthesia, and Immune Response
- Topological Materials and Phenomena
- Neural and Behavioral Psychology Studies
- Metamaterials and Metasurfaces Applications
- Regulation of Appetite and Obesity
- Neonatal and fetal brain pathology
- Neuroscience and Neural Engineering
- Genetics and Neurodevelopmental Disorders
- Neuroendocrine regulation and behavior
- Robotics and Automated Systems
University of North Carolina at Chapel Hill
2017-2024
Shanghai Jiao Tong University
2013-2021
Center for Neurosciences
2020
The supramammillary nucleus (SuM) provides substantial innervation to the dentate gyrus (DG). It remains unknown how SuM and DG coordinate their activities at circuit level regulate spatial memory. Additionally, co-releases GABA glutamate DG, but relative role of versus in regulating memory unknown. Here we report that SuM-DG Ca 2+ are highly correlated during retrieval as compared moderate correlation encoding when mice performing a location discrimination task. Supporting this evidence,...
Abstract Background Alzheimer’s disease (AD) is characterized by a progressive loss of memory that cannot be efficiently managed currently available AD therapeutics. So far, most treatments for have the potential to improve target neural circuits protect their integrity. However, vulnerable and dynamic remodeling during progression remain largely undefined. Methods Circuit-based approaches, including anterograde retrograde tracing, slice electrophysiology, fiber photometry, were used...
Quiescent neural stem cells (qNSCs) with radial morphology are the only proven source of new neurons in adult mammalian brain. Our understanding roles newly generated depends on ability to target and manipulate qNSCs. Although various strategies have been developed hippocampal qNSCs, they often suffer from prolonged breeding, low recombination efficiency, non-specific labeling. Therefore, developing a readily manufactured viral vector that allows flexible packaging robust expression...
Women are more vulnerable to stress and have a higher likelihood of developing mood disorders. The serotonin (5HT) system has been highly implicated in response regulation. However, sex-dependent mechanisms underlying serotonergic regulation vulnerability remain poorly understood. Here, we report that adult hippocampal neural stem cells (NSCs) the Ascl1 lineage (Ascl1-NSCs) female mice express functional 5HT1A receptors (5HT1ARs), selective deletion 5HT1ARs Ascl1-NSCs decreases Ascl1-NSC...
People with neuropsychiatric disorders such as schizophrenia often display deficits in spatial working memory and attention. Evaluating attention patients is usually based on traditional tasks the interviewer's judgment. We developed a simple Spatial Working Memory Attention Test Paired Symbols (SWAPS). It takes only several minutes to complete, comprising 101 trials for each subject. In this study, we tested 72 188 healthy volunteers China. control group ages ranging from 12 60, efficiency...
Studies have implied that the circadian oscillation of mitogen-activated protein kinase (MAPK) signal pathways is crucial for hippocampus-dependent memory. NF1 mouse models (Nf1 heterozygous null mutants; Nf1 +/−) displayed enhanced MAPK activity in hippocampus and resulted memory deficits. We assumed a link between hippocampal rhythmic oscillations, which never been explored +/− mice. demonstrated level extracellular signal–regulated kinases 1 2 (ERK1/2) phosphorylation mice were...
Summary Mounting evidence suggests that cognitive deficits associated with various neurological disorders may arise in part from a small population of dysregulated adult-born neurons the dentate gyrus (DG). How these contribute to brain-wide network maladaptation and subsequent remains unknown. Using an established mouse model number time-stamped immature spatial memory deficits, we performed resting state functional magnetic resonance imaging found approximately 500 deficient (<0.1%...
Adult neurogenesis is a dynamic process by which newly activated neural stem cells (NSCs) in the subgranular zone (SGZ) of dentate gyrus (DG) generate new neurons, integrate into an existing circuit and contribute to specific hippocampal functions. Importantly, adult highly susceptible environmental stimuli, allows for activity-dependent regulation various cognitive A vast range circuits from brain regions orchestrates these complex It therefore important understand how regulate...
Adult neurogenesis is a dynamic process by which newly activated neural stem cells (NSCs) in the subgranular zone (SGZ) of dentate gyrus (DG) generate new neurons, integrate into an existing circuit and contribute to specific hippocampal functions. Importantly, adult highly susceptible environmental stimuli, allows for activity-dependent regulation various cognitive A vast range circuits from brain regions orchestrates these complex It therefore important understand how regulate...
Development of a biological internet requires the development transmission and spatial information protocols. We present free-space, constant illumination light-based signaling protocol its optigenetic neuron receiver. The receiver functions as simple processor which outputs signal to connected network. maintains energy visually apparent while encoding spike trains be output from neuron. makes compatible with built environment.