A5059597264- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Autoimmune Bullous Skin Diseases
- CAR-T cell therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Eosinophilic Disorders and Syndromes
- Axon Guidance and Neuronal Signaling
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Virus-based gene therapy research
- Neurotransmitter Receptor Influence on Behavior
- Plant Molecular Biology Research
- Pluripotent Stem Cells Research
- Amyotrophic Lateral Sclerosis Research
- Prenatal Substance Exposure Effects
- Circadian rhythm and melatonin
- Herpesvirus Infections and Treatments
- Genetics and Neurodevelopmental Disorders
- Muscle Physiology and Disorders
- Amino Acid Enzymes and Metabolism
École Polytechnique Fédérale de Lausanne
2013-2024
AC Immune (Switzerland)
2024
University of Lausanne
2013-2019
Abstract Adult neurogenesis is tightly regulated by the neurogenic niche. Cellular contacts between niche cells and neural stem are hypothesized to regulate cell proliferation or lineage choice. However, structure of adult contact they form with poorly described. Here, we characterized morphology radial glia-like (RGL) cells, their molecular identity, proliferative activity, fate determination in mouse hippocampus. We found coexistence two morphotypes prototypical morphological...
Significance A population of adult neural stem cells supplies the dentate gyrus with new neurons that play a role in mechanisms learning and memory. Radial glia-like have unique morphology, including dense arbor fine processes infiltrate neurogenic niche. Here, we provide what is, to our knowledge, first detailed ultrastructural description these processes, reveal establish variety contacts local blood vessels, synapses, astrocytes. Given signals derived from neurons, astrocytes, vessels...
BackgroundEmerging evidence points to a central role of mitochondria in psychiatric disorders. However, little is known about the molecular players that regulate neural circuits regulating anxiety and depression how they impact neuronal structure function. Here, we investigated molecules involved mitochondrial dynamics medium spiny neurons (MSNs) from nucleus accumbens (NAc), hub brain's motivation system.MethodsWe assessed individual differences anxiety-like (measured via elevated plus maze...
Adult hippocampal neurogenesis results in the formation of new neurons and is a process brain plasticity involved learning memory. The proliferation adult neural stem or progenitor cells regulated by several extrinsic factors such as experience, disease aging intrinsic originating from neurogenic niche. Microglia very abundant dentate gyrus increasing evidence indicates that these mediate inflammation-induced reduction neurogenesis. However, role microglia physiological conditions remains...
Aging is associated with increased inflammation and reduced hippocampal neurogenesis, which may in turn contribute to cognitive impairment. Taurine a free amino acid found numerous diets, anti-inflammatory properties. Although abundant the young brain, decrease taurine concentration age underlie neurogenesis. Here, we assessed effect of on neurogenesis middle-aged mice. We that cell proliferation dentate gyrus through activation quiescent stem cells, resulting number cells intermediate...
A decrease in adult hippocampal neurogenesis has been linked to age-related cognitive impairment. However, the mechanisms involved this reduction remain elusive. Glucocorticoid hormones (GC) are important regulators of neural stem/precursor cells (NSPC) proliferation. GC released from adrenal glands ultradian secretory pulses that generate characteristic circadian oscillations. Here, we investigated hypothesis oscillations prevent NSPC activation and preserve a quiescent pool aging...
The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc links anxiety with competitiveness, and mitochondrial fusion protein mitofusin 2 (Mfn2) neurons regulates anxiety-related behaviors. However, it remains unexplored whether accumbal Mfn2 levels also affect behavior actions emotional domain are driven by distinct cell types. Here, we found that subordinate-prone highly anxious rats show decreased...
Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process brain plasticity involved learning memory. Although inducible-reversible transgenic mouse models are increasingly being used to investigate adult neurogenesis, transgene control requires administration an activator, doxycycline, with unknown effects on neurogenesis. Here, we tested effect doxycycline vivo. We found that 4 weeks treatment at doses commonly for gene expression control, resulted...
Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process brain plasticity involved learning memory. The neurogenic niche regulates stem cell proliferation differentiation survival major contributor to are astrocytes. Among molecules secreted by astrocytes, D-serine an important gliotransmitter co-agonist glutamate, N-methyl-D-aspartate (NMDA) receptor. has been shown enhance neural cells vitro, but its effect on adult vivo unknown. Here, we tested...
Aggression is frequently observed in neurodevelopmental psychiatric disorders such as schizophrenia, autism, and bipolar disorder. Due to a lack of understanding its underlying mechanisms, effective treatments for abnormal aggression are still missing. Recently, genetic variations Sialyltransferase 2 (St8sia2) have been linked these aggression. Here we identify aggressive behaviors concomitant blunted fear learning St8sia2 knockout (-/-) mice. It worth noting that the amygdala St8sia2-/-...
Abstract Social behaviors such as cooperation are crucial for mammals. A deeper knowledge of the neuronal mechanisms underlying can be beneficial people suffering from pathologies with impaired social behavior. Our aim was to study brain activity when two animals synchronize their behavior obtain a mutual reinforcement. In previous work, we showed that prelimbic cortex (PrL) enhanced during in rats, especially ones leading most cooperative trials ( leader rats). this study, investigated...
Postnatal hippocampal neurogenesis induces network remodeling and may participate to mechanisms of learning. In turn, the maturation survival newborn neurons is regulated by their activity. Here, we tested effect a cell-autonomous overexpression synaptic adhesion molecules on born postnatally hippocampal-dependent memory performances. Families are known induce pre- post-synaptic assembly. Using viral targeting, overexpressed three different molecules, SynCAM1, Neuroligin-1B Neuroligin-2A in...
Stimulation of resident cells by NF-κB activating cytokines is a central element inflammatory and degenerative disorders the nervous system (CNS). This disease-mediated activation could be used to drive transgene expression selectively in affected cells, using adeno-associated virus (AAV)-mediated gene transfer. We have constructed series AAV vectors expressing GFP under control different promoters including -responsive elements. As an initial screen, were tested vitro HEK-293T treated with...
Summary The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc critically implicated association between anxiety and competitiveness, mitochondrial fusion protein mitofusin 2 (Mfn2) neurons has been shown to regulate anxiety-related behaviors. However, it remains unexplored whether accumbal Mfn2 levels also affect behavior actions emotional domain are driven by distinct cell types. Here, we found that...