A5074327110- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological diseases and metabolism
- Cardiomyopathy and Myosin Studies
- Photoreceptor and optogenetics research
- Parkinson's Disease Mechanisms and Treatments
- Muscle Physiology and Disorders
- Immune Cell Function and Interaction
- Neurogenetic and Muscular Disorders Research
- Neural and Behavioral Psychology Studies
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Neuroendocrine regulation and behavior
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Monoclonal and Polyclonal Antibodies Research
- Neuroscience of respiration and sleep
- Nuclear Receptors and Signaling
- Adenosine and Purinergic Signaling
- Cardiovascular Effects of Exercise
- Nicotinic Acetylcholine Receptors Study
Dalian University
2020-2025
Union Hospital
2024
Huazhong University of Science and Technology
2024
Bernstein Center for Computational Neuroscience Berlin
2019-2023
Affiliated Zhongshan Hospital of Dalian University
2023
Humboldt-Universität zu Berlin
2022-2023
Zhejiang University of Science and Technology
2023
Shandong University of Traditional Chinese Medicine
2023
East China Normal University
2018-2022
Ocean University of China
2022
The amygdala is a brain area critical for the formation of fear memories. However, nature teaching signal(s) that drive plasticity in are still under debate. Here, we use optogenetic methods to investigate contribution ventral tegmental (VTA) dopamine neurons auditory-cued learning male mice. Using anterograde and retrograde labeling, found sparse relatively evenly distributed population VTA projects basal (BA). In vivo optrode recordings behaving mice showed many neurons, among them...
Background: Evidence shows that long non-coding RNAs (lncRNAs) are involved in individual development, cell differentiation, cycle processes and other important life closely related to major human diseases, including diabetes. Recent studies have reported lncRNAs β functions lncRNA Gas5 levels decreased T2DM patients’ serum. The purpose of this study was clarify the role mouse vitro vivo. Methods: expression normal tissues analyzed using qRT-PCR. RNAi, qRT-PCR, Annexin V-FITC assays, western...
The persistence of play after decortication points to a subcortical mechanism control. We found that global blockade the rat periaqueductal gray with either muscimol or lidocaine interfered ticklishness and play. recorded vocalizations neural activity from young, playful rats during interspecific touch, play, tickling. Rats vocalized weakly touch more strongly Periaqueductal units showed diverse but strong modulation tickling Hierarchical clustering based on neuronal responses revealed...
Reactive oxygen species (ROS) are required for the induction of long-term potentiation (LTP) and behave as signaling molecules via redox modifications target proteins. In particular, superoxide is necessary LTP, application to hippocampal slices sufficient induce LTP in area CA1. Although a rise postsynaptic intracellular calcium induction, superoxide-induced does not require flux through N-methyl-d-aspartate (NMDA) receptors. Ryanodine receptors (RyRs) mediate calcium-induced release from...
Learning about threats is essential for survival. During threat learning, an innocuous sensory percept such as a tone acquires emotional meaning when paired with aversive stimulus mild footshock. The amygdala critical memory formation, but little known upstream brain areas that process somatosensory information. Using optogenetic techniques in mice, we found silencing of the posterior insula during footshock reduced acute fear behavior and impaired 1-day memory. Insular cortex neurons...
Fibrinolytic enzymes are important components in the treatment of thrombosis-associated disorders. A new bi-functional fibrinolytic enzyme, versiase, was identified from a marine-derived fungus Aspergillus versicolor ZLH-1. The enzyme isolated fungal culture through precipitation with ammonium sulfate at 90% saturation. Additionally, it further purified by DEAE-based ion-exchange chromatography, recovery 20.4%. presented as one band on both SDS-PAGE and fibrin-zymogram, molecular mass 37.3...
This case report describes cerebral white matter abnormalities from encephalitis caused by Angiostrongylus cantonensis in a 60-year-old woman.
Thyroid hormone (TH) is recognized for its role in cellular metabolism and growth participates homeostasis of the heart. T3 activates pro-survival pathways including Akt mTOR. Treatment with after myocardial infarction cardioprotective promotes elements physiological hypertrophic response cardiac injury. Although known to benefit heart, very little about regulation at molecular level has been described date. The ubiquitin proteasome system (UPS) regulates nuclear receptors such as estrogen,...
Aggression is frequently observed in neurodevelopmental psychiatric disorders such as schizophrenia, autism, and bipolar disorder. Due to a lack of understanding its underlying mechanisms, effective treatments for abnormal aggression are still missing. Recently, genetic variations Sialyltransferase 2 (St8sia2) have been linked these aggression. Here we identify aggressive behaviors concomitant blunted fear learning St8sia2 knockout (-/-) mice. It worth noting that the amygdala St8sia2-/-...
Abstract Programmed cell death 1 (PD-1) monoclonal antibodies have been approved by regulatory agencies for the treatment of various types cancer, and mechanism involves restoration T functions. We report herein X-ray crystal structure a fully human antibody mAb059c fragment antigen-binding (Fab) in complex with PD-1 extracellular domain (ECD) at resolution 1.70 Å. Structural analysis indicates 1) an epitope, comprising fragments from C’D, BC FG loops PD-1, contributes to interaction, 2)...
Thalamic deep brain stimulation (DBS) is an effective treatment for tremor, but the mechanisms of action remain unclear. Previous studies human thalamic neurons to noted transient rebound bursting activity followed by prolonged inhibition after cessation high frequency extracellular stimulation, and present study sought identify underlying this response. Recordings from 13 exhibiting low threshold spike (LTS) brief periods were made during surgeries implant DBS leads in 6 subjects with...
The identity and location of vocalization pattern generating (VPG) circuits in mammals is debated. Based on physiological experiments, investigators suggested anterior brainstem the reticular formation, anatomic evidence nucleus retroambiguus (NRA) posterior brainstem, or combinations these sites as putative mammalian VPG. Additionally, loudness a critical factor acoustic communication. However, many underlying neuronal mechanisms are still unknown. Here, we evoked calls by stimulation...
Key points Sensory information processing in hippocampal circuits is critical for numerous hippocampus‐dependent functions, but the underlying synaptic mechanism remains elusive. We performed whole‐cell recording vivo to examine visually evoked activity CA1 pyramidal cells (PCs). first found that at resting potentials, ∼30% of PCs showed responses a flash visual stimulation. Interestingly, depolarizing nearly all were exhibit NMDA receptor‐dependent responses, indicating presence...
Abstract Clarifying learning-induced synaptic plasticity in hippocampal circuits is critical for understanding mechanisms of memory acquisition and storage. Many vitro studies have demonstrated learning-associated at synapses. However, as a neural basis encoding, the nature underlying neuronal responses to memorized stimulation remains elusive. Using vivo whole-cell recording anaesthetized adult rats mice, we investigated activity CA1 pyramidal cells (PCs) response flash visual conditioned...
Neuronal intranuclear inclusion disease (NIID) is a rare progressive neurodegenerative that mainly manifests as dementia, muscle weakness, sensory disturbances, and autonomic nervous dysfunction. Herein, we report 68-year-old Chinese woman who was hospitalized because of resting tremor bradykinesia had been present for 7 years. Five years prior, hypermyotonia become apparent. She urinary incontinence rapid eye movement sleep behavior disorder. diagnosed with Parkinson’s (PD) received...
This case report describes the magnetic resonance imaging (MRI) findings and diagnosis of scrub typhus infection in a woman who had recurrent high fever, akinetic mutism, an eschar, increase lymphocytes.