A5077225210- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Cerebrospinal fluid and hydrocephalus
- Muscle Physiology and Disorders
- Genetic and Kidney Cyst Diseases
- Fetal and Pediatric Neurological Disorders
- Memory and Neural Mechanisms
École Polytechnique Fédérale de Lausanne
2022-2025
Abstract Mitochondria play essential metabolic roles and are increasingly understood to interact with other organelles, influencing cellular function disease. Primary cilia, as sensory signalling crucial for neuronal communication function. Emerging evidence suggests that mitochondria primary cilia may regulate processes, recently shown in brain cells such astrocytes. Here, we investigated whether also neurons, focusing on molecular pathways linking both organelles structural components...
The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc links anxiety with competitiveness, and mitochondrial fusion protein mitofusin 2 (Mfn2) neurons regulates anxiety-related behaviors. However, it remains unexplored whether accumbal Mfn2 levels also affect behavior actions emotional domain are driven by distinct cell types. Here, we found that subordinate-prone highly anxious rats show decreased...
Summary The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc critically implicated association between anxiety and competitiveness, mitochondrial fusion protein mitofusin 2 (Mfn2) neurons has been shown to regulate anxiety-related behaviors. However, it remains unexplored whether accumbal Mfn2 levels also affect behavior actions emotional domain are driven by distinct cell types. Here, we found that...