Abstract It is important to pay attention the indirect effects of social distancing implemented prevent spread coronavirus disease 2019 (COVID-19) pandemic on children and adolescent health. The aim present study was explore impacts a reduction in physical activity caused by COVID-19 outbreak pediatric patients diagnosed with obesity. This conducted between pre-school closing school period 90 aged 6- 18-year-old were included. Comparing variables suffering from obesity revealed significant...

Objective Biliary atresia (BA) patients develop chronic liver disease after the Kasai operation and are eventually indicated for transplantation (LT). The purposes of this study were to analyze long-term outcomes LT risk factors that affect complications reduce graft failure. Study design Overall, 145 pediatric who underwent between June 1996 2020 a diagnosis BA included. We performed retrospective analysis medical records evaluated patient survival, cumulative incidence complications,...

A pilot study investigated the cytokine profile (IL-6, TNF-α, IL-17 A, and IL-10) at diagnosis, affecting infliximab (IFX) trough levels (TLs) in pediatric patients with Crohn's disease (CD). In this follow-up study, we evaluated changes level after treatment. Cytokines were re-measured 1 year of total anti-infliximab antibodies also measured who had started total, 29 followed up for a moderate to severe diagnosis from June 2020 2021 enrolled. The mean concentrations all cytokines one...

Background: Therapeutic drug monitoring of infliximab (IFX) can improve treatment outcomes; however, the temporal gap between concentration and subsequent availability restricts its practical application. To address this issue, an automated method, AFIAS IFX, was developed to rapidly accurately analyze IFX in blood. The analytical clinical performances method were assessed establish utility. Methods: performance evaluated according Clinical Laboratory Standard Institute guidelines. For...

Monocytes are involved in the upstream inflammatory process immune reaction bowel disease (IBD). Patients with IBD who discontinued biologics have been found to relapse, even after checking for deep remission. This study investigated whether monocytes could act as a predictor of relapse patients experienced discontinuation biologics. To this end, pediatric (<19 years old, n = 727) diagnosed from January 2003 December 2021 were retrospectively reviewed. Clinical features, monocytes,...

Abstract In pediatric Crohn’s disease (CD) patients, it is important to define the phenotype at diagnosis for stratifying risk. this retrospective study, we aimed assess compared EUROKIDS registry and analyze outcome of CD patients according upper gastrointestinal (GI) tract involvement. A total 312 were included. The median age was 13.7 years 232 (74.4%) identified have GI involvement diagnosis. Korean there significant differences in male predominance (72.8% vs. 59.2, p < 0.001),...

It is well known that infliximab (IFX) trough levels (TLs) are associated with endoscopic healing (EH) in Crohn's disease (CD). We investigated whether IFX TLs transmural (TH) pediatric patients CD following 1-year treatment. Pediatric treated were included this single-center prospective study. TL tests, magnetic resonance enterography (MRE), and colonoscopies simultaneously conducted after TH was defined as a wall thickness of ≤3 mm without inflammatory signs evaluated using MRE. EH Simple...

Primary intestinal lymphangiectasia (IL) can cause leakage of lymphatic fluids into the gastrointestinal tract, eventually leading to protein-losing enteropathy. A 15-year-old male patient, whose disease began at age 8 years, recently felt worsening general weakness. After diagnosing abnormal lesions in duodenum through endoscopy with biopsy and contrast-enhanced magnetic resonance lymphangiography, glue embolization leaking duodenal channel was successfully performed. This procedure is...

Polyomavirus BK (BKV) infection is an important cause of graft loss in kidney transplant patients.The purpose this study was to evaluate clinical findings and risk factors for BKV pediatric patients after transplantation.This retrospective single-center included 31 recipients from January 2002 December 2017. Two received 2 transplantations during the period, each analyzed independently. Total number cases 33 with patients. confirmed blood samples via periodic quantitative polymerase chain...

Abstract Few studies have demonstrated treatment strategies about the duration and cessation of medications in patients with Crohn’s disease (CD). We investigated factors affecting clinical relapse after infliximab (IFX) or azathioprine (AZA) withdrawal pediatric CD on combination therapy. Pediatric moderate-to-severe receiving therapy were analyzed retrospectively associated investigated. Discontinuation IFX AZA was performed who sustained remission (CR) for at least two years achieved deep...

Pyoderma gangrenosum is one of the dermatological extra-intestinal manifestations ulcerative colitis (UC). We report a case 26-year-old male patient suffering from relapsed UC with newly developed pyoderma gangrenosum. His skin and intestinal symptoms were intractable to treatment steroids, immunosuppressants, or single biological agent such as infliximab, golimumab, vedolizumab. For first time in Korea, we successful experience using dual agents, vedolizumab infliximab. strategically...

Background: The combination of antitumor necrosis factor-alpha (TNF-α) agents with immunomodulators (IMMs) is a common treatment for pediatric Crohn’s disease (CD). Although methotrexate (MTX) can be first-line medication as an IMM, most clinicians in real-life practice, especially South Korea, are more familiar thiopurines. This study aimed to compare the efficacy and immunogenicity MTX azathioprine (AZA) concurrent therapies CD. Methods: In this pilot study, 29 newly diagnosed patients...

The spectrum of non-alcoholic fatty liver disease (NAFLD) ranges from isolated hepatic steatosis to steatohepatitis fibrosis. We aimed introduce useful biomarkers released during inflammation and fibrogenesis that are easy use in outpatient clinic adjust children evaluate each NAFLD stage without biopsy.This prospective study included 60 patients aged under 19 years whose alanine aminotransferase (ALT) levels were elevated March 2021. All proven have by ultrasonography laboratory work-up...

This study aims to measure the concentration of cytokines produced during inflammation process investigate if there are any differences in response treatment pediatric Crohn's disease and determine initial tumor necrosis factor-alpha (TNF-α) level affected trough infliximab (IFX).This included 30 patients with moderate-to-severe disease. At time diagnosis, blood samples were collected for measurement (IL-6, TNF-α, IL-17A, IL-10). Blood extracted from who had begun IFX immediately before...

<title>Abstract</title> This study aimed to evaluate endoscopic healing (EH) efficacy and the durability of infliximab (IFX) in combination therapy with IFX AZA versus monotherapy pediatric patients Crohn’s disease (CD). In this retrospective observational study, clinical remission (CR), biochemical (BR), EH, transmural (TH) after 1-year treatment, trough levels (TLs), antibodies-to-IFX (ATIs), 108 receiving therapy, who were grouped into combo-therapy (combination group) (monotherapy...

The gastrointestinal (GI) tract is frequently affected by inborn errors of immunity (IEI), and GI manifestations can be present in IEI patients before a diagnosis confirmed. We aimed to investigate clinical features, endoscopic histopathologic findings patients. This was retrospective cohort study conducted from 1995 2020. Eligible were diagnosed with had that enough require endoscopies. classified according the International Union Immunological Societies classification. Of 165 IEI, 55...

Acute gastrointestinal graft-versus-host disease (GVHD) is a common life-threatening complication after hematopoietic stem cell transplantation (HCT). We aimed to investigate outcomes according the clinical, endoscopic, and histologic severity of GVHD in pediatric patients treated with allogeneic HCT.This retrospective cohort study included who underwent sufficient endoscopic histopathologic evaluation for clinically suspected acute between 2010 2020.Fifty-one were (male proportion, 68.6%...

The efficacy of biologics for the treatment Crohn's disease (CD) is affected by drug concentrations. We aimed to evaluate importance albumin and globulin which are known be associated with concentrations as prognostic biomarkers in CD.In total, 121 pediatric patients CD who had received anti-tumor necrosis factor (TNF)-α therapy were retrospectively examined between January 2010 February 2019.Relapse was observed 48.8% (59/121). level calprotectin (odds ratio, 2.13; p=0.03)...

Ustekinumab is a recently introduced biological agent for the treatment of Crohn's disease. The clinical use trough concentration ustekinumab not as standardized that infliximab. authors aimed to introduce measurement method and results concentrations in applications.Thirty-two blood samples from 10 young adult patients diagnosed with disease were analyzed. During maintenance treatment, injection intervals shortened 12 weeks 8 4 who exhibited loss response. measured using 2 commercial ELISA...

Ulcerative colitis (UC) is a systemic inflammatory disease with gut predominance, which may involve other organs. The presence of extraintestinal manifestation (EIM) an important symptom for clinicians as it alters the treatment decisions. In this study, we aimed to evaluate initial clinical presentation and severity pediatric UC patients EIMs.One hundred forty-two under age 18 years who were diagnosed from January 2003 November 2021 included in study. Forty-seven confirmed EIMs 95 without...

Pediatric Crohn's disease (CD) carries a higher genetic susceptibility and an increased risk of more aggressive course than adult CD. Treatment CD is based on immunomodulatory drugs, such as thiopurines. The enzyme mainly involved in drug metabolism thiopurine S-methyltransferase (TPMT). An concentration metabolites can cause adverse effects, myelosuppression hepatotoxicity; therefore, assessing the activity TPMT essential both before during treatment. genotyping result not affected by...

Abstract Background: Intestinal lymphangiectasia is a rare disease. Thus, prospective studies are impossible, and therapy still controversial. Several medicines suggested for treatment but there no existing indications drug choice guidelines. We aimed to introduce the action mechanism of each overview in single-center experience review literature on second-line primary intestinal lymphangiectasia. Method: Children under 18 years old diagnosed with from June 2000 2020 were included...