A5101647608- Gut microbiota and health
- Dermatology and Skin Diseases
- Ginseng Biological Effects and Applications
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Diet and metabolism studies
- Pharmacological Effects of Natural Compounds
- Lung Cancer Treatments and Mutations
- Hair Growth and Disorders
- Adipose Tissue and Metabolism
- Cancer Mechanisms and Therapy
- Telomeres, Telomerase, and Senescence
- Skin and Cellular Biology Research
- Histone Deacetylase Inhibitors Research
- 3D Printing in Biomedical Research
- Cytokine Signaling Pathways and Interactions
- Renal and related cancers
- Allergic Rhinitis and Sensitization
- Innovative Microfluidic and Catalytic Techniques Innovation
- Hippo pathway signaling and YAP/TAZ
- Mesenchymal stem cell research
- Dermatologic Treatments and Research
- Diet, Metabolism, and Disease
- Liver physiology and pathology
- Tryptophan and brain disorders
Kyung Hee University
2021-2024
Pusan National University
2020
Seoul National University Hospital
2017-2020
Wonkwang University
2020
Ewha Womans University
2014
Ketone bodies (KBs), such as acetoacetate and β-hydroxybutyrate, serve crucial alternative energy sources during glucose deficiency. KBs, generated through ketogenesis in the liver, are metabolized into acetyl-CoA extrahepatic tissues, entering tricarboxylic acid cycle electron transport chain for ATP production. Reduced metabolism mitochondrial dysfunction correlate with increased neuronal death brain damage cerebral ischemia neurodegeneration. Both KBs ketogenic diet (KD) demonstrate...
An in vitro screening system for anti-cancer drugs cannot exactly reflect the efficacy of vivo, without mimicking tumour microenvironment (TME), which comprises cancer cells interacting with blood vessels and fibroblasts. Additionally, size should be controlled to obtain reliable quantitative drug responses. Herein, we report a bioprinting method recapitulating TME controllable spheroid size. The was constructed by printing vessel layer consisting fibroblasts endothelial gelatine, alginate,...
Human embryonic stem cell-derived mesenchymal cells (hE-MSCs) have greater proliferative capacity than other human (hMSCs), suggesting that they may wider applications in regenerative cellular therapy. In this study, to uncover the anti-senescence mechanism hE-MSCs, we compared hE-MSCs with adult bone marrow (hBM-MSCs) and found hepatocyte growth factor (HGF) was more abundantly expressed hBM-MSCs it induced transcription of RAD51 facilitated its SUMOylation at K70. induction/modification by...
Epidermal growth factor receptor (EGFR) is overexpressed in lung cancer patients. Despite treatment with various EGFR tyrosine kinase inhibitors, recurrence and metastasis of are inevitable. Docetaxel (DTX) an effective conventional drug that used to treat cancers. Several researchers have studied the use traditional herbal medicine combination docetaxel, improve treatment. SH003, a novel mixture, exerts anticancer effects different cell types. Here, we aimed investigate apoptotic SH003 DTX,...
Alopecia, a prevalent yet challenging condition with limited FDA-approved treatments which is accompanied by notable side effects, necessitates the exploration of natural alternatives. This study elucidated hair growth properties Gynostemma pentaphyllum leaf hydrodistillate (GPHD) both in vitro and vivo. Furthermore, damulin B, major component GPHD, demonstrated growth-promoting vitro. Beyond its established anti-diabetic, anti-obesity, anti-inflammatory attributes, GPHD exhibited induction...
Transforming growth factor β (TGFβ) is a crucial in fibrosis, and transcriptional intermediary 1γ (TIF1γ) negative regulator of the TGFβ pathway; however, its role liver fibrosis unknown. In this study, mesenchymal stem cells derived from human embryonic (hE-MSCs) that secrete hepatocyte (HGF) were used to observe repair thioacetamide (TAA)-induced fibrosis. Our results showed TIF1γ was significantly decreased LX2 when exposed TGFβ1. Such decrease prevented by co-culture with hE-MSCs....
The intestinal microbiome is considered one of the key regulators health. Accordingly, severity atopic dermatitis (AD) mediated by skin and environment. In this study, while evaluating aggravation in AD symptoms antibiotics cocktail (ABX)-induced depletion microbiome, we sought to verify effect Gardenia jasminoides (GJ), a medicinal herb used for inflammatory diseases, on regarding its role microbiome. To induced established novel mouse model administrating an ABX create microbiome-free...
Although the anti-obesity effect of Korean red ginseng (Panax Meyer) has been revealed, its underlying mechanisms are not clearly understood. Here, we demonstrate an involvement gut microbiome in inhibitory on high-fat-diet (HFD)-induced mouse obesity, and further provides information effects saponin-containing extract (SGE) saponin-depleted (GE). Mice were fed with either SGE or GE every third day for one month, their food intakes, fat weights, plasma glucose, insulin leptin levels...
Objectives: This study was conducted to examine the preferences and needs of typical Korean females adults for food nutrition information provided by mass media. Methods: A total 343 (77 in their 20s, 85 30s, 88 40s 93 50s) residing Seoul/Gyeonggido area surveyed on general characteristics, main sources contents information. Results: The survey showed that obtained knowledge mainly through Internet (30.4%) broadcasting (29.0%). Typical were interested 'dietary management weight control'...
Lung cancer (LC) is the leading global cause of cancer-related death, and metastasis a great challenge in LC therapy. Additionally, solid cancer, including lung, prostate, colon are characterized by hypoxia. A low-oxygen state facilitated oncogene pathway, which correlates with poor prognosis. Thus, we need to understand related mechanisms tumors improve develop new anticancer strategies. The experiments herein describe an mechanism heat shock protein 90 (HSP90) stabilizes HIF-1α, master...
본 연구의 목적은 반려견 웹사이트의 서비스 품질이 소비자의 신뢰에 미치는 영향을 파악하고, 외로움이 조절 역할을 하는지를 실증분석하는 것이다. 2019년 7월 5일부터 7일까지 부산에서 개최한 애견박람회 참가자를 대상으로 설문조사를 실시하여 회수한 212부를 분석을 하였다. 웹사이트 서비스품질의 측정도구를 개발한 결과 선행연구에서 개발된 e-서비스품질 요인(효율성, 이용가능성, 프라이버시, 이행성) 외에 특성을 고려한 네 가지 요인(즐거움, 중심, 개인화, 커뮤니티) 이 새로이 추출되었다. 주요 결과는 다음과 같다. 첫째 서비스품질 중 5가지 요인(이행성, 즐거움, 커뮤니티)이 정(+)의 미치고 있으며 매장 신뢰에는 프라이버시만 유의한 있다. 둘째, 신뢰는 셋째, 신뢰의 매개효과는 이행성-웹사이트신뢰-매장신뢰, 프라이버시-웹사이트신뢰-매장신뢰, 즐거움-웹사이트신뢰-매장신뢰, 커뮤니티-웹사이트신뢰-매장신뢰, 반려견중심-웹사이트신뢰-매장신뢰 등의 다섯 경로에서 유의하게 나타났다....
이 연구는 도시 노인을 대상으로 여가활동 만족이 생활만족에 미치는 영향을 파악하고, 그 과정에서 여가시설 만족의 매개효과를 규명하는 데 목적이 있다. 도시노인의 특성에 주목하고자 2021년 전라북도 사회조사원자료를 바탕으로 지역에 거주하는 65세 이상 노인 2,302명의 데이터를 추출하여 분석하였다. 또한 남성 노인과 여성 각각 변수 간의 관계와 살펴보기 위해 두 집단을 나누어 분석을 실시하였다. 분석 결과, 남녀 만족은 이용 만족에 긍정적인 미치며, 노인의 생활 만족도에 유의미한 정적 것으로 나타났다. 또한, 노인에게서만 매개효과가 나타났으며, 경우 영향이 유의하지 않았다. 이러한 결과는 여가와 관련된 정책을 개발할 때 성별에 따른 특성을 고려할 필요성을 시사한다.
Objectives: This study aims to investigate the effects of transitions in caregiving on caregivers’ health. Although many previous studies have identified psychological outcomes family caregiving, research health affected by is rarely conducted. Method: Data Korean Longitudinal Study Aging from 2012 2014 were analyzed. The demographic characteristics caregiver derived basic statistics. In addition, Generalized Eqution Estimation(GEE) investigated effect transition depression and subjective...