A5052464072- Hair Growth and Disorders
- Skin and Cellular Biology Research
- Dermatologic Treatments and Research
- Cancer and Skin Lesions
- Wnt/β-catenin signaling in development and cancer
- melanin and skin pigmentation
- Skin Protection and Aging
- Ginseng Biological Effects and Applications
- Mesenchymal stem cell research
- Pharmacological Effects of Natural Compounds
- Dermatology and Skin Diseases
- Acne and Rosacea Treatments and Effects
- Air Quality and Health Impacts
- Natural product bioactivities and synthesis
- Exercise and Physiological Responses
- Reproductive System and Pregnancy
- Indoor Air Quality and Microbial Exposure
- Extracellular vesicles in disease
- Wound Healing and Treatments
- Medical and Biological Ozone Research
- Kruppel-like factors research
- Antioxidant Activity and Oxidative Stress
- Tendon Structure and Treatment
- Dupuytren's Contracture and Treatments
- Genetic and rare skin diseases.
Kyungpook National University
2015-2024
Kyungpook National University Hospital
2021-2023
Abstract Dermal papillae ( DP ) play key roles in hair growth and regeneration by regulating follicular cell activity. Owing to the established of exosomes (Exos) regulation functions, we investigated whether ‐derived Exos, especially those from three‐dimensional (3D)‐cultured cells, affect growth, cycling regeneration. Exos derived 3D (3D ‐Exos) promoted proliferation cells outer root sheath ORS increased expression factors IGF ‐1, KGF HGF cells. ‐Exo treatment also shaft elongation...
Hair loss is a common medical problem affecting both males and females. Dermal papilla (DP) cells are the ultimate reservoir of with potential hair regeneration in patients. Here, we analyzed role macrophage-derived Wnts (3a 7b) macrophage extracellular vesicles (MAC-EVs) promoting growth. We studied proliferation, migration, expression growth factors human-DP presence or absence MAC-EVs. Additionally, tested effect MAC-EV treatment on mouse model human follicles. Data from western blot flow...
Skin barrier disruption is a significant problem of the older population in an aging society. It characterized by increased transepidermal water loss and decreased skin content, particulate matter (PM) social issue that can contribute to exacerbation inflammation. Thus, addressing this urgent.
Hypoxia induces the survival and regenerative potential of adipose-derived stem cells (ASCs), but there are tremendous needs to find alternative methods for ASC preconditioning. Therefore, this work investigated: (1) ability low-dose ultraviolet B (UVB) radiation stimulate survival, migration, tube-forming activity ASCs in vitro; (2) UVB preconditioning enhance hair growth-promoting capacity vivo; (3) mechanism action stimulation by UVB. Although high-dose decreased proliferation ASCs, (10...
Although adipose-derived stem cells (ASCs) show promise for cell therapy, there is a tremendous need developing ASC activators. In the present study, we investigated whether or not vitamin C increases survival, proliferation, and hair-regenerative potential of ASCs. addition, tried to find molecular mechanisms underlying C-mediated stimulation Sodium-dependent transporter 2 (SVCT2) expressed in ASCs, mediates uptake into Vitamin increased survival proliferation ASCs dose-dependent manner....
Alopecia, a prevalent yet challenging condition with limited FDA-approved treatments which is accompanied by notable side effects, necessitates the exploration of natural alternatives. This study elucidated hair growth properties Gynostemma pentaphyllum leaf hydrodistillate (GPHD) both in vitro and vivo. Furthermore, damulin B, major component GPHD, demonstrated growth-promoting vitro. Beyond its established anti-diabetic, anti-obesity, anti-inflammatory attributes, GPHD exhibited induction...
l-Ascorbic acid 2-phosphate (Asc 2-P), a derivative of l-ascorbic acid, promotes elongation hair shafts in cultured human follicles and induces growth mice.To investigate whether the promotion by Asc 2-P is mediated insulin-like factor-1 (IGF-1) and, if so, to mechanism 2-P-induced IGF-1 expression.Dermal papilla (DP) cells were level was measured reverse transcription-polymerase chain reaction enzyme-linked immunosorbent assay after treatment absence or presence LY294002,...
Aging (senescence) is an unavoidable biological process that results in visible manifestations all cutaneous tissues, including scalp skin and hair follicles. Previously, we evaluated the molecular function of adenosine promoting alopecia treatment vitro. To elucidate differences mechanisms between minoxidil (MNX) adenosine, gene expression changes dermal papilla cells were examined. The androgen receptor (AR) pathway was identified as a candidate target for growth, anti-androgenic activity...
Fatty acid-CoA ligase 4 (FACL4) is a central enzyme controlling the unesterified free arachidonic acid (AA) level in cells and AA known to induce apoptosis. We have recently reported that expression of FACL4 upregulated about 40% human hepatocellular carcinoma (HCC) 50% HCC cell lines, suggesting may be involved liver carcinogenesis. In this study, we investigated whether growth regulated by FACL4. Immunoblot analysis showed SNU 398 express very low or no detectable We, therefore,...
Particulate matter (PM) can cause oxidative stress, inflammation, and skin aging. We investigated the effects of antioxidants such as dieckol, punicalagin, epigallocatechin gallate (EGCG), resveratrol, Siegesbeckiae Herba extract (SHE) against PM < 10 μm (PM10) on serum IgE concentration, mast cell counts, inflammatory cytokines, keratinocyte differentiation markers in a 2,4-Dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model. Seven-week-old BALB/c mice were sensitized with 2%...
Hair loss is a prevalent medical condition affecting both genders. In this study, we investigate the effects of specific class extracellular vesicles (EVs), namely human normal fibroblast-derived EVs (hFB-EVs), on dermal papilla (DP) and outer root sheath (ORS) cells examine molecular mechanisms responsible for hair growth in follicles (HFs). We find that Wnt3a, which maintains hair-generating activity DP cells, enriched more strongly associated with hFB-EVs than fibroblasts. Furthermore,...
Dermal papillae (DP) and outer root sheath (ORS) cells play important roles in hair growth regeneration by regulating the activity of follicle (HF) cells.To investigate effects human mesenchymal stem cell-derived extracellular vesicles (hMSC-EVs) on DP ORS as well HFs. EVs are known to regulate various cellular functions. However, hMSC-EVs growth, particularly human-derived HF (DP cells), possible mechanisms underlying these unknown.hMSC-EVs were isolated characterized using transmission...
Glypican-3 (GPC3) is a member of the glypican family, which encodes cell-surface heparan-sulfate proteoglycans, and frequently upregulated in hepatocellular carcinoma (HCC). We have recently reported that blocking endogenous GPC3 expression promotes growth HCC cell lines, suggesting plays negative role proliferation. Here, we report forced reduced cells. also found FGF2- mediated proliferation was inhibited by GPC3. In addition, observed adhesion cells to collagen type I fibronectin...