A5077870402- Developmental Biology and Gene Regulation
- Genomics and Chromatin Dynamics
- Biochemical effects in animals
- NF-κB Signaling Pathways
- Alcohol Consumption and Health Effects
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Neurobiology and Insect Physiology Research
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Natural product bioactivities and synthesis
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant Molecular Biology Research
- Bone health and treatments
- Ginseng Biological Effects and Applications
- Cytokine Signaling Pathways and Interactions
- Phytochemistry and Biological Activities
- Animal Genetics and Reproduction
- RNA modifications and cancer
- Bone Metabolism and Diseases
- GABA and Rice Research
- Advanced Glycation End Products research
Kyung Hee University
2009-2018
The Ohio State University
2001-2010
Kyung Hee University East-West Neo Medical Center
2010
University of California, Berkeley
2007-2009
Innovative Genomics Institute
2008-2009
Nationwide Children's Hospital
2003
Hallym University
1995-1999
Some developmentally important genes can be regulated via two enhancers, one located nearby and the other, a "shadow" enhancer, 10 to 20 kilobases away.
RNA Polymerase II (Pol II) is bound to the promoter regions of many or most developmental control genes before their activation during Drosophila embryogenesis. It has been suggested that Pol stalling used produce dynamic and rapid responses patterning transient cues such as extracellular signaling molecules. Here, we present a combined computational experimental analysis stalled promoters determine how they come bind in early embryo. At least one-fourth contain shared sequence motif, "pause...
Cinnamon bark is one of the most popular herbal ingredients in traditional oriental medicine and possesses diverse pharmacological activities including anti-bacterial, anti-viral, anti-cancer properties. The goal this study to investigate vivo vitro inhibitory effect cinnamon water extract (CWE) on lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α its underlying intracellular mechanisms.CWE was orally administrated mice for 6 days prior intraperitoneal injection LPS. Serum...
Many developmental control genes contain stalled RNA Polymerase II (Pol II) in the early Drosophila embryo, including four of eight Hox genes. Here, we present evidence that promoters possess an intrinsic insulator activity. The enhancer-blocking activities these are dependent on general transcription factors inhibit Pol elongation, components DSIF and NELF complexes. conventional insulators also impaired embryos containing reduced levels NELF. Thus, promoter-proximal stalling might help...
Rhus verniciflua Stokes (RVS) has been used as a traditional herbal medicine for its various biological activities including anti-adipogenic effects. Activity-guided separation led to the identification of functions butein. Butein, novel compound, robustly suppressed lipid accumulation and inhibited expression adipogenic markers. Molecular studies showed that activated transforming growth factor-β (TGF-β) signal transducer activator transcription 3 (STAT3) signaling pathways were mediated by...
World epidemic obesity is a major contributing factor to metabolic diseases including insulin resistance and cardiovascular diseases. In this study, aqueous ethanolic extracts of hulled barley with roasting temperatures up 250 °C were investigated for their anti-adipogenic effects in vitro vivo. An extract roasted at 210 (AHB210) effectively inhibited adipocyte differentiation. Intraperitoneal injections 15 or 50 mg/kg AHB210 dose dependently prevented body weight gain, fat mass increase,...
The ZAS proteins are large zinc-finger transcriptional implicated in growth, signal transduction, and lymphoid development. Recombinant fusion containing one of the two DNA-binding domains have been shown to bind specifically κB motif, but endogenous or their physiological functions largely unknown. GGGACTTTCC, is a gene regulatory element found promoters enhancers genes involved immunity, inflammation, growth. Rel family NF-κB, predominantly p65.p50 p50.p50, transcription factors well known...
Previous studies showed that feeding diets containing the mature fruits of Sophora japonica L. prevented body weight gain and reduced fat mass in high-fat diet-induced obese mice. This observation has led to hypothesis extracts from S. may inhibit adipocyte differentiation preadipocytes. To elucidate possible mechanisms for anti-obesity action L., its effects on were investigated C3H10T1/2 mesenchymal stem cells 3T3-L1 preadipocyte cells. The fruit was partitioned with ethanol, hexane,...
The maternal transcription factor Dorsal (Dl) functions as both an activator and a repressor in context-dependent manner to control dorsal-ventral patterning the Drosophila embryo. Previous studies have suggested that Dl is intrinsic its repressive activity requires additional corepressors bind corepressor-binding sites near Dl-binding sites. However, molecular identities of yet be identified. Here, we present evidence Capicua (Cic) involved Dl-mediated repression...
Abstract: The structural differences between two types of glutamate dehydrogenase (GDH) isoproteins (GDH I and GDH II), homogeneously isolated from bovine brain, were investigated using a biosensor technology monoclonal antibodies. A total seven antibodies raised against II produced, the recognized single protein band that comigrates with purified on sodium dodecyl sulfatepolyacrylamide gel electrophoresis immunoblot. Of anti‐GDH tested in immunoblot analysis, all interacted II, whereas only...
The bark of Rhus verniciflua Stokes (RVS) is used as a food additive and herbal medicine for various inflammatory disorders cancer in Eastern Asia. RVS has been shown to exert anti-inflammatory effects lipopolysaccharide (LPS)-stimulated macrophages vitro, but whether oral administration affects the response macrophage needs be verified. was given orally mice ten days. For isolation macrophages, intraperitoneal injection thioglycollate performed. determination serum response, LPS applied....