A5071852246- Nanopore and Nanochannel Transport Studies
- Lipid Membrane Structure and Behavior
- Microfluidic and Capillary Electrophoresis Applications
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Genetics, Aging, and Longevity in Model Organisms
- Polydiacetylene-based materials and applications
- Membrane Separation Technologies
- Analytical Chemistry and Sensors
- Antimicrobial Peptides and Activities
- Innovative Microfluidic and Catalytic Techniques Innovation
- Ionic liquids properties and applications
- Biosensors and Analytical Detection
- Supramolecular Self-Assembly in Materials
- Membrane-based Ion Separation Techniques
- RNA Interference and Gene Delivery
- Spaceflight effects on biology
- Electrochemical sensors and biosensors
- Ocular Surface and Contact Lens
- Advanced Chemical Sensor Technologies
- Nanoplatforms for cancer theranostics
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Electrowetting and Microfluidic Technologies
Inha University
2016-2025
The University of Sydney
2024
Incheon Medical Center
2015-2018
Government of the Republic of Korea
2011-2017
Hanbat National University
2012
University of California, Los Angeles
2005-2009
California NanoSystems Institute
2007
We have observed a common sequence motif in membrane proteins, which we call glycine zipper. Glycine zipper motifs are strongly overrepresented and conserved protein sequences, mutations deleterious to function many cases. The has significant structural impact, engendering strong driving force for right-handed packing against neighboring helix. Thus, the presence of leads directly testable hypotheses, particularly subclass proteins that form channels. For example, suggest pores formed by...
A developmentally inspired tissue engineering method enables the construction of microphysiological musculoskeletal models.
Synthetic biomimetic membranes provide biological environments to membrane proteins. By exploiting the central roles of membranes, it is possible devise biosensors, drug delivery systems, and nanocontainers using a system integrated with functional Biomimetic can be created synthetic lipids or block copolymers. These amphiphilic polymers self-assemble in an aqueous solution either into planar vesicles. Using various techniques developed date, both vesicles versatile robust platforms for...
In this work, numerical and experimental analyses have been conducted to analyze the effect of different shapes obstructions (diamond, rectangular, circular) on mixing performance a micromixer with Tesla structures. Fluid flow behaviors were numerically analyzed by solving Navier–Stokes equations using convection-diffusion model in Reynolds number range 0.2–200. structure can produce transverse dispersion splitting recombining fluid streams. Micromixers fabricated soft lithography technique...
We have encapsulated free-standing planar lipid membranes in a polymer hydrogel via situ photopolymerization. These were measured to last at least 5 days and provided stable environment for single-molecule measurements of incorporated alpha-hemolysin channel proteins. The translocation single-stranded DNA through into these is slowed over 100 times relative that the gel-free state. stabilized membranes, therefore, application analysis as well broader biomolecular sensors, membrane protein...
Ionic liquids (ILs) are often considered to be green solvents based on their unusual stability, although toxicity living organisms has become an emerging issue a number of recent studies. We assume that one the main reasons for this high level cell is molecular interactions between ILs and membranes. In study, we used model cells demonstrate can incorporate into lipid membranes, resulting in perturbation membrane structure. employed various methods elucidate membranes ILs. Our results...
We developed a simple and sensitive colorimetric biosensor in the form of microparticles by using polydiacetylene (PDA) vesicles encapsulated within hydrogel matrix for detection phosphinothricin acetyltransferase (PAT) protein, which is one most important marker proteins genetically modified (GM) crops. Although PDA commonly used as sensing material due to its unique properties, existing biosensors are ineffective their low sensitivity well lack robustness. To overcome these disadvantages,...
Perturbation of potassium homeostasis can affect various cell functions and lead to the onset programmed death. Although ionophores have been intensively used as an ion disturber, mechanisms death are unclear bioapplicability is limited. In this study, helical polypeptide-based developed induce endoplasmic reticulum (ER) stress-mediated apoptosis. The disturb then prolonged ER stress in cells. results oxidative environments that accelerate activation mitochondria-dependent Moreover,...
Reactive oxygen species (ROS) are chemically reactive oxygen-containing compounds generated by various factors in the body. Antioxidants mitigate damaging effects of ROS playing a critical role regulating redox balance and signaling. In this study, interplay between antioxidants context lipid dynamics were investigated. The interaction hydrogen peroxide (H2O2) as an vitamin E (α-tocopherol) antioxidant was examined. Model membranes containing both saturated unsaturated lipids served...
Lipid bilayer membranes have been extensively utilized to examine membrane channel and pore proteins are the subjects of study in their own right. There has considerable recent interest developing technologies substitute or strengthen lipid for a number applications, including sensing drug delivery. In particular, biomimetic amphiphilic block co-polymers shown capacity form structures contain within them. this work, we describe creation from 5.7 nm thick tri-block co-polymer investigation...
We present a microfluidic platform for the formation and electrical measurement of lipid bilayer membranes. Using electrowetting on dielectric (EWOD), two or more aqueous droplets surrounded by lipid-containing organic phase were manipulated into contact to form at their interface. Thin-film Ag/AgCl electrodes integrated device enabled membrane incorporation gramicidin channels bilayers in parallel.
Bilayer membranes that are covalently conjugated in situ to an encapsulating hydrogel have been formed. These extremely long-lived, lasting over ten days standard laboratory conditions, and sufficiently fluid support protein incorporation. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2008/c0810_s.pdf or from author. Please note: The publisher not responsible content functionality of any supporting supplied by authors. Any...
A colorimetric polydiacetylene (PDA) paper strip sensor that can specifically recognize Bacillus thuringiensis (BT) HD-73 spores is described in this work. The target-specific aptamer was combined with PDA, and the aptamer-conjugated PDA vesicles were then coated on polyvinylidene fluoride (PVDF) strips by a simple solvent evaporation method. PDA-aptamer be used to detect target without any pre-treatment. Using strip, presence of BT directly observable naked eye based unique blue-to-red...