A5100671524- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Photoacoustic and Ultrasonic Imaging
- Gold and Silver Nanoparticles Synthesis and Applications
- Extracellular vesicles in disease
- Graphene and Nanomaterials Applications
- Cancer-related Molecular Pathways
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- Bioinformatics and Genomic Networks
- Acute Myeloid Leukemia Research
- RNA and protein synthesis mechanisms
- Gene Regulatory Network Analysis
- Gene expression and cancer classification
- SARS-CoV-2 detection and testing
- Biosensors and Analytical Detection
- MicroRNA in disease regulation
- Carbon and Quantum Dots Applications
- Cancer Cells and Metastasis
- Protein Degradation and Inhibitors
- Mental Health Research Topics
Georgia Institute of Technology
2019-2025
University of California, Davis
2024-2025
The Wallace H. Coulter Department of Biomedical Engineering
2019-2025
University of Notre Dame
2024
University of Kentucky
2021-2024
Markey Cancer Center
2021-2024
Bridge University
2024
Kwangwoon University
2022-2023
Pohang University of Science and Technology
2013-2020
Ulsan National Institute of Science and Technology
2018-2019
Graphene oxide has unique physiochemical properties, showing great potential in biomedical applications. In the present work, functionalized reduced graphene (PEG-BPEI-rGO) been developed as a nanotemplate for photothermally triggered cytosolic drug delivery by inducing endosomal disruption and subsequent release. PEG-BPEI-rGO ability to load greater amount of doxorubicin (DOX) than unreduced PEG-BPEI-GO via π-π hydrophobic interactions, high water stability. Loaded DOX could be efficiently...
Abstract Challenges in drug development of neurological diseases remain mainly ascribed to the blood–brain barrier (BBB). Despite valuable contribution animal models discovery, it remains difficult conduct mechanistic studies on function and interactions with drugs at molecular cellular levels. Here we present a microphysiological platform that recapitulates key structure human BBB enables 3D mapping nanoparticle distributions vascular perivascular regions. We demonstrate on-chip mimicry by...
Stimuli‐responsive gene delivery systems maximize therapeutic efficacy by controlling the cytosolic conveyance and rate of effective release. We present herein a hybrid nanocomposite composed 2D nanomaterial, MoS 2 , modified attaching two polymers (polyethylenimine (PEI) polyethylenglycol (PEG)) via disulfide bonds. This –PEI–PEG interacts with DNA electrostatic interaction, accordingly forms nanosized complex high stability. Photothermal conversion nanosheet is employed in order to induce...
We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The is composed pH-jump reagent as an intermediary stimulus and calcium phosphate (CaP) coating shielding layer NO release. light irradiation subsequent acid generation are used triggers uncapping releasing NO. acids generated from light-activated agent loaded in mesoporous nanoparticles accelerated degradation CaP-coating layers on nanoparticles, facilitating release diazeniumdiolate by...
Abstract In the present study, design, construction, and operation of a functional DNA‐decorated dynamic gold (Au) nanomachine as therapeutic agent for triple combinatorial anti‐cancer therapy are revealed. Taking advantage intrinsic optical properties Au nanoparticles, which depend on their size, cytosine rich i‐motif sequence is employed intracellular pH‐sensitive duplex dissociation subsequent aggregation DNA‐Au nanomachine, enabling anticancer drug release photothermal ablation upon...
Abstract Tumors are 3D, composed of cellular agglomerations and blood vessels. Therapies involving nanoparticles utilize specific accumulations due to the leaky vascular structures. However, systemically injected mostly uptaken by cells located on surfaces cancer tissues, lacking deep penetration into core regions. Herein, an unprecedented strategy, described as injecting “nanoparticle‐loaded nanoparticles” address long‐lasting problem is reported for effective surface‐to‐core drug delivery...
Focused ultrasound–mediated delivery of RNA-loaded nanoparticles increases brain tumor cell apoptosis through oncogene targeting.
Prolonged accumulation of misfolded proteins in the endoplasmic reticulum (ER) results ER stress-mediated apoptosis. Cyclophilins are protein chaperones that accelerate rate folding through their peptidyl-prolyl cis-trans isomerase (PPIase) activity. In this study, we demonstrated stress activates expression ER-localized cyclophilin B (CypB) gene a novel response element. Overexpression wild-type CypB attenuated stress-induced cell death, whereas overexpression an activity-defective mutant,...
We present herein a pH-responsive dynamic DNA nanocluster based on gold nanoparticles with highly packed nucleic acid assembly and evaluate its potential as drug delivery vehicle tumor-specific accumulation. Each nanoparticle was readily functionalized various functional sequences; in particular, we modified the surface of bcl-2 antisense i-motif binding sequences. Clustering induced by hybridization each sequence via provided tumor targeting loading capabilities. After cellular uptake,...
The present work illustrates unique design, construction and operation of an i-motif-based DNA nanomachine templated on gold nanoparticles (AuNPs), which utilizes pH-responsive dynamic motion i-motif strands aggregational behavior AuNPs to elicit programmed delivery therapeutic siRNA. pH-sensitive nucleic acids immobilized the consisted three functional segments, i.e., DNA, overhanging linker a At neutral pH, is hybridized with segment However, in endosomal acidic forms interstrand...
Pathway-based analysis in genome-wide association study (GWAS) is being widely used to uncover novel multi-genic functional associations. Many of these pathway-based methods have been test the enrichment associated genes pathways, but exhibited low powers and were highly affected by free parameters. We present method software GSA-SNP2 for pathway GWAS P-value data. provides high power, decent type I error control fast computation incorporating random set model SNP-count adjusted gene score....
Single-layered molybdenum sulfide (MoS2) displays strong photothermal properties, but low colloidal stability in aqueous solution prevents its biomedical application as a functional drug delivery carrier. We report photothermally controllable nanoplate consisting of porous silica-coated, single-layered MoS2, modified with poly(ethylene glycol) (PEG). Silica and PEG enhanced maintained the single layer structure MoS2 for over month. A representative anticancer drug, doxorubicin (DOX), was...
Incorporation of a desired stimuli-responsive unit in stereospecific manner at the specific location within nonlinear block copolymer architecture is challenging task synthetic polymer chemistry. Herein, we report facile and versatile method to synthesize AB2 miktoarm copolymers bearing singlet oxygen (1O2)-labile regio β-aminoacrylate linkage with 100% E-configuration junction via combination amino-yne click chemistry ring opening polymerization. Using this strategy, series 1O2-responsive...
A biomechanical study on the cadaveric human lumbar spine.We focused a comparison of changes wrought motion segments after minimally invasive decompression and conventional medial facetectomy.Minimally posterior using microscope or an endoscope is becoming popular for elderly patients with spinal canal stenosis. An advantage technique that cauda equina nerve roots are in clear view facet joints, paravertebral muscles, spinous process well preserved.Eight were used this study. Each specimen...
Graphene oxide (GO) has attracted huge interest in the area of biomedical application due to its unique physicochemical properties, but issue long-term toxicity body remains unclear. Here, rationally designed GO nanocarriers (ssPEG-PEI-GO) modified with polyethylene glycol (PEG) and branched polyethylenimine (BPEI) via disulfide linkage are described control biological activity as a delivery carrier degradation systems. The ssPEG-PEI-GO efficiently interacts plasmid DNA (pDNA) form stable...
Significance This study shows that an engineered biomimetic nanoparticle decorated with a targeting ligand and loaded sonic hedgehog inhibitor maintains its stability in the circulation, crosses blood–brain barrier (BBB), delivers drug molecules to cancer stem-like cell population subtype of medulloblastoma. Leveraging natural capabilities high-density lipoprotein, our enables facilitated targeted cellular uptake drugs receptor-mediated intracellular cholesterol depletion medulloblastoma...
Matrix metalloproteinase-9 (MMP-9) plays major roles in extracellular matrix (ECM) remodeling and membrane protein cleavage, suggesting a high correlation with cancer cell invasion tumor metastasis. Here, we present contrast agent based on DNA aptamer that can selectively target human MMP-9 the microenvironment (TME) affinity sensitivity. Surface modification of plasmonic gold nanospheres its complementary sequences allows to aggregate presence through displacement hybridization. Aggregation...