A5013827651- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Ultrasound and Cavitation Phenomena
- CCD and CMOS Imaging Sensors
- Particle Detector Development and Performance
- Advanced MRI Techniques and Applications
- Infrared Target Detection Methodologies
- Digital Radiography and Breast Imaging
- Radiation Detection and Scintillator Technologies
- Advanced X-ray and CT Imaging
- Advanced Neuroimaging Techniques and Applications
- Black Holes and Theoretical Physics
- Microfluidic and Bio-sensing Technologies
- Quantum Chromodynamics and Particle Interactions
- Medical Imaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Barrier Structure and Function Studies
- Lanthanide and Transition Metal Complexes
- MRI in cancer diagnosis
- Extracellular vesicles in disease
- Particle physics theoretical and experimental studies
Georgia Institute of Technology
2016-2025
The Wallace H. Coulter Department of Biomedical Engineering
2019-2024
Emory University
2019-2022
Mayo Clinic in Arizona
2020
Brigham and Women's Hospital
2011-2017
Harvard University
2012-2016
University of Oxford
2008-2013
Institute of Biomedical Science
2011
University College London
2006-2009
Imperial College London
1995-1997
The blood-brain barrier (BBB) prevents entry of most drugs into the brain and is a major hurdle to use for tumors other central nervous system disorders. Work in small animals has shown that ultrasound combined with an intravenously circulating microbubble agent can temporarily permeabilize BBB. Here, we evaluated whether this targeted drug delivery method be applied safely, reliably, controlled manner on rhesus macaques using focused system. We identified clear safety window during which...
Significance Improved penetration along with accurate prediction and mechanistic understanding of anticancer agent delivery across the blood–brain/blood–tumor barrier (BBB/BTB) are essential for rational development effective therapeutic strategies in intracranial malignancies. In this study, we provide insights drug pharmacokinetics brain metastases after focused ultrasound-induced BBB/BTB disruption by integrating quantitative microscopy mathematical modeling. We demonstrate that...
The ability of ultrasonically-induced oscillations circulating microbubbles to permeabilize vascular barriers such as the blood-brain barrier (BBB) holds great promise for noninvasive targeted drug delivery. A major issue has been a lack control over procedure ensure both safe and effective treatment. Here, we evaluated use passively-recorded acoustic emissions means achieve this control. An monitoring system was constructed integrated into clinical transcranial MRI-guided focused ultrasound...
Significance The blood–brain barrier (BBB) is a critical obstacle to delivering most therapeutics into the brain. In this study, we report combined MRI, histological, and real-time acoustic emissions monitoring findings from Phase 0 clinical trial examining microbubble-enhanced transcranial focused ultrasound for controlled BBB opening in patients with infiltrating gliomas. data revealed capability of technology provide safe, controlled, tightly monitored through intact skull. Our...
Focused ultrasound–mediated delivery of RNA-loaded nanoparticles increases brain tumor cell apoptosis through oncogene targeting.
Focused ultrasound, when combined with circulating microbubbles (MB-FUS), leads to temporary neurovascular permeability and blood brain barrier opening (BBBO). Numerous trials using different devices, treatment parameters, monitoring technologies have created a need for approaches enabling comparative evaluation standardization of MB-FUS treatments. Analyzing 1028 unique sonications performed in patients gliomas, we investigated patient-specific, operator-adjusted, device-related variables...
Several emerging therapies with potential for use in the brain, harness effects produced by acoustic cavitation—the interaction between ultrasound and microbubbles either generated during sonication or introduced into vasculature. Systems developed transcranial MRI-guided focused (MRgFUS) thermal ablation can enable their clinical translation, but methods real-time monitoring control are currently lacking. Acoustic emissions provide information about location, strength type of microbubble...
In the present proof of principle study, we evaluated homogenous angular spectrum method for passive acoustic mapping (AS-PAM) microbubble oscillations using simulated and experimental data. data assessed ability AS-PAM to form 3D maps a single multiple point sources. Then, in two dimensional limit, compared 2D from with alternative frequency time domain (FD- TD-PAM) approaches. Finally, visualize activity vivo obtained during 8 different experiments FUS-induced blood-brain barrier...
OBJECT Transcranial MRI-guided focused ultrasound (TcMRgFUS) is an emerging noninvasive alternative to surgery and radiosurgery that undergoing testing for tumor ablation functional neurosurgery. The method currently limited central brain targets due skull heating other factors. An ablative approach combines very low intensity bursts intravenously administered microbubble agent locally destroy the vasculature. objective of this work was investigate whether it feasible use at deep near base...
Despite the challenges in treating glioblastomas (GBMs) with immune adjuvants, increasing evidence suggests that targeting cells within tumor microenvironment (TME) can lead to improved responses. Here, we present a closed-loop controlled, microbubble-enhanced focused ultrasound (MB-FUS) system and test its abilities safely effectively treat GBMs using checkpoint blockade. The proposed fine-tune exposure settings promote MB acoustic emission-dependent expression of proinflammatory marker...
Purpose: Ultrasound can be used to noninvasively produce different bioeffects via viscous heating, acoustic cavitation, or their combination, and these effects exploited develop a wide range of therapies for cancer other disorders. In order accurately localize control effects, imaging methods are desired that map both temperature changes cavitation activity. To address needs, the authors integrated an ultrasound array into MRI‐guided focused (MRgFUS) system simultaneously visualize thermal...
Effective drug delivery in brain tumors remains a major challenge oncology. Although local hyperthermia and stimuli-responsive systems, such as thermosensitive liposomes, represent promising strategies to locally enhance solid improve outcomes, their application intracranial malignancies unexplored. We hypothesized that the combined abilities of closed-loop trans-skull Magnetic Resonance Imaging guided Focused Ultrasound (MRgFUS) with those drugs can alleviate challenges survival gliomas....
The interaction of ultrasonically-controlled microbubble oscillations with tissues and biological media has been shown to induce a wide range bioeffects that may have significant impact on therapy diagnosis brain diseases disorders. However, the inherently non-linear combined micrometer microsecond scales involved in these interactions limited methods assess visualize them transcranially hinder both their optimal use translation clinics. To overcome challenges, we present framework combines...
Overcoming transport barriers to delivery of therapeutic agents in tumors remains a major challenge. Focused ultrasound (FUS), combination with modern nanomedicine drug formulations, offers the ability maximize tumor tissue while minimizing toxicity normal tissue. This potential unfulfilled due limitations current approaches accurately assessing and quantifying how FUS modulates solid tumors. A novel acoustofluidic platform is developed by integrating physiologically relevant 3D microfluidic...
X-ray diffraction studies give material-specific information about biological tissue. Ideally, a large area, low noise, wide dynamic range digital x-ray detector is required for laboratory-based studies. The goal of this work to introduce novel imaging technology, the CMOS active pixel sensor (APS) that has potential fulfil all these requirements, and demonstrate its feasibility coherent scatter imaging. A prototype APS been included in an demonstration system. An industrial source with...
Abstract Here we describe a novel method to noninvasively modulate targeted brain areas through the temporary disruption of blood-brain barrier (BBB) via focused ultrasound, enabling focal delivery neuroactive substance. Ultrasound was used locally disrupt BBB in rat somatosensory cortex and intravenous administration GABA then produced dose-dependent suppression somatosensory-evoked potentials response electrical stimulation sciatic nerve. No observed 1–5 days afterwards or control animals...
Ultrasonically actuated microbubble oscillations hold great promise for minimally invasive therapeutic interventions. However their successful translation to the clinic, real-time methods control amplitude and type of micro-bubble (stable versus inertial acoustic cavitation) ensure that cavitation occurs within targeted region are needed. In this paper, we propose a nonlinear state controller uses specific frequency bands emissions (harmonic, ultra-harmonic, etc.) activity (observer states)....
Monolithic complementary metal oxide semiconductor (CMOS) active pixel sensors with high performance have gained attention in the last few years many scientific and space applications. In order to evaluate increasing capabilities of this technology, particular where low dose resolution x‐ray medical imaging is required, critical electro‐optical physical evaluation was determined. The includes read noise, full well capacity, interacting quantum efficiency, pixels cross talk. performance,...