A5055712365- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Transplantation: Methods and Outcomes
- Viral-associated cancers and disorders
- Phagocytosis and Immune Regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Donation and Transplantation
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Infrared Thermography in Medicine
- Sleep and Wakefulness Research
- Lipid metabolism and disorders
- Lipoproteins and Cardiovascular Health
- Immunotherapy and Immune Responses
- Epilepsy research and treatment
- Immune Cell Function and Interaction
- Hops Chemistry and Applications
- Cardiac Imaging and Diagnostics
- Plant Disease Resistance and Genetics
- Kruppel-like factors research
- Hydrogen's biological and therapeutic effects
- Immune cells in cancer
- Hepatitis B Virus Studies
Georgia Institute of Technology
2024-2025
Emory University
2025
The Wallace H. Coulter Department of Biomedical Engineering
2024
Ulsan College
2007-2014
University of Ulsan
2007-2014
Asan Medical Center
2007-2014
We investigated the mechanism by which cannabinoid receptors-1 (CB1) and -2 (CB2) modulate inflammatory activities of macrophages. Real-time polymerase chain reaction showed predominant CB2 expression in freshly isolated human monocytes. PMA, a potent inducer differentiation, upregulated CB1 increased CB1:CB2 transcript ratio from 1:17.5 to 1:3 5 days culture. Immunohistochemistry that protein was colocalized CD68- CD36-positive macrophages atheroma. Through selective or...
AimsThe present study investigated the detailed mechanism by which fractalkine (Fkn), a CX3C chemokine, induces angiogenesis and its functional implication in alleviating ischaemia vivo.
Background Atherosclerosis occurs preferentially in the arteries exposed to disturbed flow (d-flow), while stable (s-flow) regions are protected even under hypercholesterolemic conditions. We recently showed that d-flow alone initiates flow-induced reprogramming of endothelial cells (FIRE), including novel concept partial endothelial-to-immune-cell-like transition (partial EndIT), but was not validated using a genetic lineage-tracing model. Here, we tested and two-hit hypothesis is an...
Atherosclerosis occurs preferentially in the arteries exposed to disturbed flow (d-flow), while stable (s-flow) regions are protected even under hypercholesterolemic conditions. We recently showed that d-flow alone initiates flow-induced reprogramming of endothelial cells (FIRE), including novel concept partial endothelial-to-immune-cell-like transition (partial EndIT), but was not validated using a genetic lineage-tracing model. Here, we tested and two-hit hypothesis is an initial...
Although the recruitment of macrophages to lung is a central feature airway inflammation, its function in ongoing T(h)2 cell-mediated eosinophilic inflammation remains controversial. Here, we have demonstrated that allergen-induced CD11b(+) CD11c(int) macrophage expressing CC chemokine receptor 3 (CCR3) performs crucial induction asthma murine model. In lungs normal mice, residential cells evidencing high granularity phenotypically evidenced CD11b(int) CD11c(+) or cells, appearing at 2:1...
The relative frequency, clinical features and survival outcomes of secondary cutaneous lymphoma remain poorly understood.To determine the characteristics lymphoma.The present retrospective cohort study included all 106 patients who presented with lymphoma. Patient medical records were reviewed to features, prognostic factors. Survival analysed by using Kaplan-Meier method comparisons between cell lineages [T or natural killer (T-/NK)-cell vs. B-cell lymphoma] performed log-rank...
Little is known about hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase expression in human coronary atherosclerotic plaques.To investigate the of HMG-CoA atherectomy tissues obtained from patients with unstable and stable angina examine relationship plaque instability.Atherectomy specimens were 43 (n=22) or (n=21) who underwent directional for de novo artery lesions. The stained haematoxylin-eosin incubated antibodies specific to reductase, macrophages, smooth muscle cells endothelial...
Abstract A major challenge to brain cancer immunotherapy is posed by the rate-limiting obstacles systemic delivery of cytotoxic T cells, such as chimeric antigen receptor (CAR) in tumors blood barrier (BBB). Although BBB can be bypassed direct infusion CAR-T cells tumors, these approaches offer only short-term benefits, since they cannot affect distant tumor cell infiltrations, evidenced relapse. Circulating microbubbles (MB) upon ultrasound (US) exposure (sonication) exert mechanical stress...
Background: Calcific aortic valve disease (CAVD) is a highly prevalent disease, especially in the elderly population, but there are no effective drug therapies other than repair or replacement. CAVD develops preferentially on fibrosa side, while ventricularis side remains relatively spared through unknown mechanisms. We hypothesized that prone to due side-dependent differences transcriptomic patterns and cell phenotypes. Methods: To test this hypothesis, we performed single-cell RNA...
Background: ABO-incompatible (ABOi) living liver donor can be considered to a valuable option for pool expansion without additional risk. The poor recipient outcome in early experience, however, has limited its widespread application. Recently, the promising results under rituximab prophylaxis have been reported. Method: We started ABOi adult transplantation (LDLT) from November 2008. special preparation overcome ABO incompatibility consisted of preoperative (300˜375 mg/mm2 BSA) and...
Introduction: Liver transplantation(LT) has been established treatment for the patients with irreversible acute and chronic liver diseases. However, because of scarcity cadaveric grafts, living-donor transplantation (LDLT) emerged as an alternative to cadaveric-donor (CDLT) in Korea. Eight percent Korean population are hepatitis B virus (HBV) carriers, resultant HBV cirrhosis, or without hepatocellular carcinoma (HCC), is common 40- 60-year-old generation. Methods: In 1992, first CDLT was...