A5067212318- Platelet Disorders and Treatments
- Blood disorders and treatments
- Blood groups and transfusion
- Biochemical effects in animals
- Coenzyme Q10 studies and effects
- Cardiac Valve Diseases and Treatments
- Sirtuins and Resveratrol in Medicine
- Aortic Thrombus and Embolism
- Aortic Disease and Treatment Approaches
Emory University
2019-2024
Children's Healthcare of Atlanta
2024
The Wallace H. Coulter Department of Biomedical Engineering
2024
Georgia Institute of Technology
2024
Center for Cancer and Blood Disorders
2021
National Chung Hsing University
2019
Capsaicin (8-methyl-N-vanillyl-6-noneamide), which is an active component in red chili peppers, used as a chemopreventive agent that shows favorable cytotoxicity against cancer cells. Accumulating evidence indicates capsaicin preferentially inhibits tumor-associated NADH oxidase (tNOX, ENOX2) ubiquitously expressed but not non-transformed This attenuates cell growth by inducing apoptosis. The capsaicin-mediated inhibition of tNOX was recently shown to prolong the cycle. However, molecular...
Background: Calcific aortic valve disease (CAVD) is a highly prevalent disease, especially in the elderly population, but there are no effective drug therapies other than repair or replacement. CAVD develops preferentially on fibrosa side, while ventricularis side remains relatively spared through unknown mechanisms. We hypothesized that prone to due side-dependent differences transcriptomic patterns and cell phenotypes. Methods: To test this hypothesis, we performed single-cell RNA...