A5027492877- Dermatologic Treatments and Research
- Skin Protection and Aging
- melanin and skin pigmentation
- Cutaneous Melanoma Detection and Management
- Ion channel regulation and function
- Nail Diseases and Treatments
- Lymphoma Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Salivary Gland Tumors Diagnosis and Treatment
- Viral-associated cancers and disorders
- Tumors and Oncological Cases
- Acne and Rosacea Treatments and Effects
- Oral and Maxillofacial Pathology
- Cutaneous lymphoproliferative disorders research
- Ginseng Biological Effects and Applications
- Mast cells and histamine
- Nietzsche, Schopenhauer, and Hegel
- Sympathectomy and Hyperhidrosis Treatments
- Melanoma and MAPK Pathways
- Oral Health Pathology and Treatment
- Dermatological diseases and infestations
- Dermatological and Skeletal Disorders
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Eosinophilic Disorders and Syndromes
Asan Medical Center
2013-2018
University of Ulsan
2007-2018
Ulsan College
2008-2018
Johns Hopkins University
1977
Several studies observed that adiponectin, an important adipokine improves glucose metabolism by regulating AMP-activated protein kinase (AMPK) signaling, is dermatologically beneficial. In our recent microarray data, we found adiponectin expression was lower in lesional skin than non-lesional of melasma patients. Given AMPK a key signaling mediator, investigated the role and AICAR, cell-permeable activator, melanogenesis. We herein showed AICAR downregulated MITF, tyrosinase, TRP-1, DCT...
The relative frequency, clinical features and survival outcomes of secondary cutaneous lymphoma remain poorly understood.To determine the characteristics lymphoma.The present retrospective cohort study included all 106 patients who presented with lymphoma. Patient medical records were reviewed to features, prognostic factors. Survival analysed by using Kaplan-Meier method comparisons between cell lineages [T or natural killer (T-/NK)-cell vs. B-cell lymphoma] performed log-rank...
Fractional laser resurfacing treatment has been extensively investigated and is widely used. However, the mechanism underlying its effects poorly understood because of ethical cosmetic problems obtaining skin biopsies required to study changes after treatment. To evaluate usefulness human explants for investigation fractional photothermolysis. Full-thickness discarded was treated in 4 ways: no (control), carbon dioxide laser, Er:YAG 1,550-nm erbium-doped fiber laser. Both non-treated samples...
We have demonstrated previously that the 20(<i>S</i>) but not 20(<i>R</i>) form of ginsenoside Rg<sub>3</sub> inhibited K<sup>+</sup> currents flowing through Kv1.4 (hKv1.4) channels expressed in <i>Xenopus laevis</i> oocytes, pointing to presence specific interaction site(s) for hKv1.4 channel. In current study, we sought identify this site(s). To end, first assessed how point mutations various amino acid residues channel affected inhibition by 20(<i>S</i>)-ginsenoside (Rg<sub>3</sub>)....
Laser toning using low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum laser (QSNY) has gained popularity in the treatment of photoaging-associated mottled pigmentation (PMP). However, hypopigmentation or lack efficacy been reported depending on fluences used.To compare a novel fractional QSNY with conventional for pigmentary lesions except epidermal lentigines and freckles through randomized, split-face, double-blind study.Thirteen Asian women were treated every week 6 weeks one...
Journal Article Facial and extrafacial eosinophilic pustular folliculitis: a clinical histopathological comparative study Get access W.J. Lee, Lee Department of Dermatology Asan Medical Center University Ulsan College Medicine 388‐1 Pungnapdong Songpagu Seoul 138‐736 Korea Correspondence Mi Woo Lee. E‐mail: jijulee@hanmail.net Search for other works by this author on: Oxford Academic Google Scholar K.H. Won, Won C.H. S.E. Chang, Chang J.H. Choi, Choi K.C. Moon, Moon M.W. British Dermatology,...
Café-au-lait macules (CALMs) are benign epidermal basilar hyperpigmentations that can be found in an isolated form or association with neurocutaneous syndromes. Frequency-doubled Q-switched neodymium-doped yttrium aluminum garnet laser (532-nm QSNYL) does not penetrate deeply into the skin and is therefore suitable for pigmented lesion. Fractional photothermolysis (FP) targets only very small areas of skin, without injuring adjacent healthy, normal skin. Herein, we report a case CALMs...
Background:The clinical and histopathological characteristics of acquired bilateral nevus Ota-like macules in men are poorly documented due to its rarity.Aims: To compare the with condition women.Methods: We studied 11 62 women, all a diagnosis macules.Biopsies were taken from 5 10 women their features compared.Results: The most frequently affected site was forehead [8 (73%) out patients].Lesions on more common than (P = 0.001).In contrast there no apparent tendency lesions become blue age...
The clinical features of nasal rosacea have not been described in detail.To describe the rosacea.599 patients were classified into those with both and extra-nasal areas (group A), localized B) without involvement C).The mixed subtype was more common group A (n = 337) than C 231). severity score higher C. Erythematotelangiectatic most B 31) A. Rosacea mainly affected lower half nose B, but entire A.Nasal may be an index severe rosacea. Localized is a separate spectrum different features.
Tyrosine kinase inhibitors (TKIs) are associated with various adverse cutaneous reactions, including pigmentary changes. Radotinib is a novel and selective BCR‐ABL1 TKI, which has shown activity safety in the treatment of patients chronic myeloid leukaemia resistant or intolerant to imatinib. A 69‐year‐old Korean man presented lentiginosis after taking radotinib for 6 months. On histopathological examination, numbers melanocytes melanin pigment were found be increased due c‐KIT activation,...
Keratoacanthomas (KAs) are a well-known cutaneous side effect of BRAF inhibitors and multiple lesions continue to develop throughout the course therapy. We present case an 81-year old women diagnosed with metastatic melanoma who underwent six weeks vemurafenib She developed vemurafenib-induced KAs applied 5% imiquimod cream three times week. successfully treated topical application clearance these was further confirmed by dermoscopic examination. Topical can be effective treatment option for...
• A mother and her two children had hearing loss associated with bilateral preauricular sinus branchiogenic fistula. All six cochleas studied showed turns rather than 2½ turns. Complete studies including audiometry, tympanotomy findings, temporal bone polytomography of these anomalies are reported. Similar cases reported in the English literature reviewed. It seems that all previous may have an abnormal cochlea as was seen cases. (<i>Arch Otolaryngol</i>103:676-680, 1977)
Dear Editor: Here, we describe a case of acquired dermal melanocytosis involving the dorsum in an Asian woman. A 45-year-old Korean woman presented with 3-year history relatively well-demarcated, pale, blue-grayish, asymptomatic round patch on her interscapular back area (Fig. 1). Hypertrichosis was not observed within lesion. Physical examination revealed no other similar lesions elsewhere. The patient denied any preceding inflammatory changes, trauma, bruises, tattoos, or metal contact...
Cutaneous metastasis from gastric adenocarcinoma is uncommon, and the eyelid a rare metastatic site. Three patterns of clinical presentation have been described: nodular, infiltrative, ulcerated. The infiltrative pattern, also known as an inflammatory diffuse pattern or mask-like metastasis, can be easily misdiagnosed cellulitis contact dermatitis. Here, we report case in 75-year-old man who presented with localized erythematous plaque on his that developed four months earlier. patient had...
Dear Editor: A 62-year-old man presented with a 5-month history of solitary subcutaneous nodule on the right cheek that. On physical examination, there was 2-cm flesh-toned round (Fig. 1). The mass soft and somewhat fluctuant palpation without tenderness. Histopathologic examination revealed multiple well-circumscribed tumor nests solid, lobular, microcystic structures 2A). A large portion cells displayed serous acinar differentiation cytoplasmic granules, termed zymogen-like granules...