A5062738042- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Cardiac pacing and defibrillation studies
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Toxic Organic Pollutants Impact
- Neural and Behavioral Psychology Studies
- Neuropeptides and Animal Physiology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Circadian rhythm and melatonin
- Food Industry and Aquatic Biology
- Phytochemical and Pharmacological Studies
- Cardiac Ischemia and Reperfusion
- Hormonal Regulation and Hypertension
- Memory and Neural Mechanisms
- Environmental Toxicology and Ecotoxicology
- Decision-Making and Behavioral Economics
- Medicinal plant effects and applications
- Salivary Gland Disorders and Functions
- Lipid Membrane Structure and Behavior
- Ion Transport and Channel Regulation
- Photoreceptor and optogenetics research
Kangwon National University
2013-2024
Advanced Institute of Convergence Technology
2024
Dong-A University Hospital
2023
National University College
2003-2019
New Generation University College
2014-2019
Yeungnam University
2019
Institute for Basic Science
2013-2016
Chonnam National University
2014
Ajou University
2009-2013
University of Miami
2012
In neurons, the type 3 deiodinase (D3) inactivates thyroid hormone and reduces oxygen consumption, thus creating a state of cell-specific hypothyroidism. Here we show that hypoxia leads to nuclear import D3 in without which signaling metabolism cannot be reduced. After unilateral rat brain, protein level is increased predominantly nucleus neurons pyramidal granular ipsilateral layers, as well hilus dentate gyrus hippocampal formation. culture human neuroblastoma cell line (SK-N-AS), 24 h...
Posttranslational modification of target substrates underlies biological processes through activation/inactivation signaling cascades. To concurrently identify the phosphoprotein associated with cardiac β-adrenergic signaling, mouse myocyte phosphoproteome was analyzed using 2-D gel electrophoresis in combination 32 P autoradiography. Phosphoprotein spots, detected by silver staining, were identified MALDI-TOF mass spectrometry conjunction computer-assisted protein spot matching. Stimulation...
Amitriptyline has been known to induce QT prolongation and torsades de pointes which causes sudden death. We studied the effects of amitriptyline on human ether‐a‐go‐go ‐related gene ( HERG ) channel expressed in Xenopus oocytes rapidly activating delayed rectifier K + current (I Kr rat atrial myocytes. The amplitudes steady‐state currents tail were decreased by dose‐dependently. decrease became more pronounced at positive potential, suggesting that block is voltage dependent. IC 50 for was...
Performance during perceptual decision-making exhibits an inverted-U relationship with arousal, but the underlying network mechanisms remain unclear. Here, we recorded from auditory cortex (A1) of behaving mice passive tone presentation, while tracking arousal via pupillometry. We found that discriminability in A1 ensembles was optimal at intermediate revealing a population-level neural correlate relationship. explained this arousal-dependent coding using spiking model clustered...
Clozapine, a commonly used antipsychotic drug, can induce QT prolongation, which may lead to torsades de pointes and sudden death. To investigate the arrhythmogenic side effects of clozapine, we studied impact clozapine on human ether ‐ go ‐related gene ( HERG ) channels expressed in Xenopus oocytes HEK293 cells, delayed rectifier K + currents guinea‐pig cardiomyocytes. Clozapine dose‐dependently decreased amplitudes at end voltage steps, tail HERG. The IC 50 for blockade progressively...
Activation of p38 mitogen-activated protein kinase (MAPK) plays a central role in cellular responses to multitude stress signals. In the heart, enhanced MAPK signaling has been implicated cardiac hypoxic and ischemic injury. However, mechanism underlying hypoxia-induced activation remains elusive. We investigated during hypoxia adult rat cardiomyocytes. Here, we reported that leads concurrent intracellular acidosis can be fully abolished by neutralizing pH, whereas (intracellular pH<7.0) per...
One of the common side effects antihistamine medicines is xerostomia (dry mouth). The current consensus that antihistamine-induced comes from an antimuscarinic effect. Although effect antihistamines on salivary secretion both obvious and significant, cellular mechanism whereby this happens still unclear because lack knowledge histamine signaling in human glands. Here, we have studied receptors submandibular acinar cells. In primary cultured gland a HSG cell line, increased intracellular...
Reinforcement learning theories postulate that actions are chosen to maximize a long-term sum of positive outcomes based on value functions, which subjective estimates future rewards. In simple reinforcement algorithms, functions updated only by trial-and-error, whereas they according the decision-maker's knowledge or model environment in model-based algorithms. To investigate how animals update we trained rats under two different free-choice tasks. The reward probability unchosen target...
Abstract Anterior insular and orbitofrontal cortex (AIC OFC, respectively) are known to play important roles in decision making under risk. However, risk-related AIC neural activity has not been investigated it is controversial whether the rodent OFC conveys genuine risk signals. To address these issues, we examined neuronal rats responding five distinct auditory cues predicting water reward with different probabilities. Both structures conveyed significant signals for reward, value risk,...
Trifluoperazine, a commonly used antipsychotic drug, has been known to induce QT prolongation and torsades de pointes, which can cause sudden death. We studied the effects of trifluoperazine on human <i>ether</i>-<i>a</i>-<i>go</i>-<i>go</i>-related gene (HERG) channel expressed in <i>Xenopus</i> oocytes delayed rectifier K<sup>+</sup> current guinea pig cardiomyocytes. The application showed dose-dependent decrease amplitudes at end voltage steps tail currents HERG. IC<sub>50</sub> for...
Polychlorinated biphenyls (PCBs) have been known as serious environmental pollutants, causing developmental delays, motor dysfunction, and decrease in brain dopamine level humans animals. We investigated the effects of a PCB congener, 2,2′,6-trichlorobiphenyl (PCB 19) on contractile force, Ca2+ transient, L-type current (ICa,L) guinea pig ventricular myocytes stimulated at rate 0.25–0.33 Hz. 19 decreased force concentration-dependent manner. During negative inotropic response, action...
The effects of paroxetine, a selective serotonin reuptake inhibitor, on human ether-a-go-go-related gene (HERG) channels were investigated using the whole-cell patch-clamp technique. HERG stably expressed in embryonic kidney cells. Paroxetine inhibited peak tail currents channel concentration-dependent manner, with an IC50 value 0.45 µM and Hill coefficient 0.85. These reversible after wash-out drug. paroxetine-induced inhibition was voltage-dependent. There steep increase over voltage range...
Chlorpromazine, a commonly used antipsychotic drug, has been known to induce QT prolongation and torsades de pointes, which can cause sudden death. We studied the effects of chlorpromazine on human ether-a-go-go-related gene (HERG) channel expressed in Xenopus oocytes delayed rectifier K current guinea pig ventricular myocytes. Application showed dose-dependent decrease amplitudes steady-state currents tail HERG. The became more pronounced at increasingly positive potential, suggesting that...