A5090888027- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Electrospun Nanofibers in Biomedical Applications
- Advanced Drug Delivery Systems
- Nanopore and Nanochannel Transport Studies
- Supramolecular Self-Assembly in Materials
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- CAR-T cell therapy research
- Ultrasound and Cavitation Phenomena
- RNA modifications and cancer
- Lipid Membrane Structure and Behavior
- Hydrogels: synthesis, properties, applications
- Supercapacitor Materials and Fabrication
- Immune Cell Function and Interaction
- Graphene and Nanomaterials Applications
- Corneal Surgery and Treatments
Inha University
2022-2025
University of Michigan
2017-2023
BioSurfaces (United States)
2017-2023
Harvard University
2020
Brigham and Women's Hospital
2020
Korea Institute of Science and Technology
2012-2017
Pohang University of Science and Technology
2009-2014
Institute for Basic Science
2014
Ajou University
2008-2011
Photothermal therapy (PTT) is a promising cancer treatment modality, but PTT generally requires direct access to the source of light irradiation, thus precluding its utility against disseminated, metastatic tumors. Here, we demonstrate that combined with chemotherapy can trigger potent anti-tumor immunity disseminated Specifically, have developed polydopamine-coated spiky gold nanoparticles as new photothermal agent extensive stability and efficiency. Strikingly, single round sub-therapeutic...
Although immune checkpoint blockade has shown initial success for various cancers, only a small subset of patients benefits from this therapy. Some chemotherapeutic drugs have been reported to induce antitumor T cell responses, prompting number clinical trials on combination chemoimmunotherapy. However, how achieve potent activation with traditional chemotherapeutics in manner that is safe, effective, and compatible immunotherapy remains unclear. We show high-density lipoprotein-mimicking...
Abstract The non-invasive photodynamic therapy has been limited to treat superficial tumours, primarily ascribed poor tissue penetration of light as the energy source. Herein, we designed a long-circulating hydrophilized titanium dioxide nanoparticle (HTiO 2 NP) that can be activated by ultrasound generate reactive oxygen species (ROS). When administered systemically mice, HTiO NPs effectively suppressed growth tumours after treatments. In tumour tissue, levels proinflammatory cytokines were...
Polymeric gene delivery vectors show great potential for the construction of ideal system. These systems harness their ability to incorporate versatile functional traits overcome most impediments encountered in delivery: from initial complexation target-specific release therapeutic nucleic acids at cytosol. Among numerous multifunctional polymers that have been designed and evaluated as vectors, with redox-sensitive (or bioreducible) domains gained attention terms structural traits. The...
Abstract Conventional chemotherapy is plagued with adverse side effects because cancer treatments are subject to numerous variations, most predominantly from drug resistance. Accordingly, multiple or multistage chemotherapeutic regimens often performed, combining two more drugs orthogonal and possibly synergistic mechanisms. In this respect, glycol chitosan (GC)-based nanoparticles (CNPs) serve as an effective platform vehicle that can encapsulate both chemotherapeutics siRNA achieve maximal...
Innate immune cells recognize and respond to pathogen-associated molecular patterns. In particular, polysaccharides found in the microbial cell wall are potent activators of dendritic (DCs). Here, we report a new class nanocapsules, termed sugar-capsules, entirely composed derived from wall. We show that sugar-capsules with flexible polysaccharide shell hollow core efficiently drain lymph nodes activate DCs. mannan (Mann-capsule) carrying mRNA (mRNA) promote strong DC activation,...
Nanoparticles (NPs) can serve as a promising vaccine delivery platform for improving pharmacological property and codelivery of antigens adjuvants. However, NP-based vaccines are generally associated with complex synthesis postmodification procedures, which pose technical manufacturing challenges tailor-made production. Here, modularly programmed, polyethyleneimine (PEI)-based NP reported simple production personalized cancer vaccines. Briefly, PEI is conjugated neoantigens by facile...
The present work illustrates unique design, construction and operation of an i-motif-based DNA nanomachine templated on gold nanoparticles (AuNPs), which utilizes pH-responsive dynamic motion i-motif strands aggregational behavior AuNPs to elicit programmed delivery therapeutic siRNA. pH-sensitive nucleic acids immobilized the consisted three functional segments, i.e., DNA, overhanging linker a At neutral pH, is hybridized with segment However, in endosomal acidic forms interstrand...
Theranostic nanoparticles hold great promise for simultaneous diagnosis of diseases, targeted drug delivery with minimal toxicity, and monitoring therapeutic efficacy.However, one the current challenges in developing theranostic is enhancing tumor-specific targeting both imaging probes anticancer agents.Herein, we report development tumor-homing echogenic glycol chitosan-based (Echo-CNPs) that concurrently execute cancer-targeted ultrasound (US) US-triggered delivery.To construct this novel...
Gliomas are brain tumors with dismal prognoses. The standard-of-care treatments for gliomas include surgical resection, radiation, and temozolomide administration; however, they have been ineffective in providing significant increases median survival. Antigen-specific cancer vaccines immune checkpoint blockade may provide promising immunotherapeutic approaches gliomas.
Transferrin (TF) is widely used as a tumor-targeting ligand for the delivery of anticancer drugs because TF receptor overexpressed on surface various fast-growing cancer cells. In this article, we report nanoparticles an siRNA carrier in vivo tumor-specific gene silencing. To produce carrying (NPs), both and were chemically modified with sulfhydryl groups that can build up self-cross-linked siRNA-TF NPs. Self-polymerized 5′-end thiol-modified (poly siRNA, psi) thiolated transferrin (tTF)...