Objective: This study aimed to compare the efficacy and safety of romosozumab, a bone anabolic agent, versus vertebroplasty, conventional surgical intervention, in treating osteoporotic vertebral compression fractures (OVCFs).Methods: A retrospective analysis included 86 thoracic/lumbar fracture patients from 2014 2022 at medical center. Forty-two received romosozumab (monthly injections for 1 year) followed by year denosumab, while 44 underwent vertebroplasty denosumab biannually 2 years....

In Brief Study Design. Prospective study. Objective. To analyze the effect of T1 slope on kyphotic alignment change after cervical laminoplasty in patients with myelopathy. Summary Background Data. Laminoplasty is a posterior method, and maintenance both preoperative postoperative lordotic prerequisite for successful surgery. Unfortunately, who underwent tend to have operation despite sufficient lordosis, such can reduce surgical outcome require additional Methods. Consecutive myelopathy...

The majority of earlier studies the parameters sagittal balance did not consider influence spinal muscles on alignment.To analyze relationship between paraspinal muscle (quantity and quality) alignment in elderly patients.We reviewed 50 full-spine lateral standing radiographs lumbar magnetic resonance images patients at a single center. radiographic examined were thoracic kyphosis, lordosis (LL), vertical axis, pelvic tilt, sacral slope, incidence (PI). muscularity (LM; quantity) fatty...

We performed a retrospective analysis of medical records and radiographic images patients who never underwent spinal treatment including diagnosis. The objective this study is to explain the biomechanical physiologic characteristics cervical alignment related thoracic inlet angle T1 slope changes in each individual.We reviewed CT radiographs 80 visited ENT outpatient clinic without any symptom, diagnosis spine from January 2011 September 2012. All targeted people were randomized prejudice....

In Brief Study Design. Retrospective study. Objective. To determine age-related changes in cervical sagittal alignment using whole-spine standing radiographs asymptomatic adults. Summary of Background Data. Modern surgical techniques have emphasized the importance maintaining proper alignment. But there is a paucity literature investigating Methods. One hundred healthy unoperated adults who were free spinal problems obtained radiographs. They consisted 2 groups divided by age: those their...

Retrospective study.The purpose of this study was to analyze the relationship parameters cervical sagittal alignment between those obtained from CT and radiography, as well determine which parameter would help predict physiological lordosis spine.Sagittal balance in spine is important pelvic incidence related concept T1 slope. However, many articles including article based on unclear x-ray radiographs could weakly explain parameters. To overcome fundamental limitation radiographs, Hallym...

Benchtop cadaveric biomechanical comparative testing and caprine animal model in vivo implantation.To evaluate the role of posterior longitudinal ligament cervical arthroplasty to understand relative contribution this nonfusion applications.Rauschning refers as "The Kleenex Ligament" due its apparent anatomic insignificance. White Panjabi found ranked only fourth importance tensile load-to-failure testing. In postoperative situation following anterior diskectomy fusion, integrity is...

In Brief Study Design. To evaluate the in vitro interactions between human mesenchymal stem cells (MSCs) and degenerative disc cells. Objectives. demonstrate potential of MSCs regulating extracellular matrix synthesis Summary Background Data. Culture followed by their reinsertion into a can retard degeneration process an animal model. However, harvesting without accelerating is problematic. Autologous be safely harvested from bone marrow transplanted discs. Methods. Human nucleus pulposus...

Retrospective analysis.The main objectives of this study were to analyze and compare cervical sagittal parameters, including the T1 slope, in a population 45 patients with degenerative spondylolisthesis (DCS) these control group asymptomatic population.Sagittal balance spine is as important pelvic incidence related concept slope. Compared lumbar spondylolisthesis, there are few studies evaluating DCS, characteristic changes parameters (including slope) DCS not well studied.We identified...

Obesity is a serious global health challenge, closely associated with numerous chronic conditions including type 2 diabetes. Anemarrhena asphodeloides Bunge (AA) known as Jimo has been used to address pathogenic heat such wasting-thirst in Korean Medicine. Timosaponin A3 (TA3), natural compound extracted from AA, demonstrated potential therapeutic effects various disease models. However, its on diabetes and obesity remain largely unexplored. We investigated the anti-obesity anti-diabetic...

Background. Many clinicians perform glycolic acid peels for facial acne patients, but there has not been a well-controlled study to compare this new therapy with other conventional modalities. Objective. To the effectiveness of treatment and side effects in by two agents, 70% Jessner's solution. Methods. Twenty-six patients were treated simultaneously solution biweekly on each face. The sides randomized evaluation was done blinded evaluator who did know randomization code. Dr. Cunliffe's...

In Brief Study Design. This study evaluates the effect of iliac screw fixation versus interbody femoral ring allograft (FRA) on lumbosacral kinematics and sacral strain in long segment instrumentations. Objective. (1) Quantify kinematic properties 3 techniques; (2) Evaluate as instrumented levels extend cephalad; (3) Determine whether screws or FRA biomechanically protect screws. Summary Background Data. High failure rates at junction have been reported with posterior instrumentation ending...

Postoperative delirium is a risk factor for worse outcome after hip fracture surgery in elderly patients. associated with anesthesia, postoperative pain, and patient factors. We investigated the incidence, predictors, prognostic implications of post-operative hemiarthroplasty (HA) patients femoral neck fracture.A total 356 consecutive aged >70 years who underwent HA were enrolled. Diagnosis was made by psychiatrist based on status an objective scoring system. The divided into 2 categories...

This study investigated the effects of Lycium chinense Mill (LCM) extract on obesity and diabetes, using both in vitro high-fat diet (HFD)-induced mouse models. We found that LCM notably enhanced glucagon-like peptide-1 (GLP-1) secretion NCI-h716 cells from 411.4 ± 10.75 pg/mL to compared NT (78.0 0.67 pg/mL) without causing cytotoxicity, implying involvement Protein Kinase A C (PKA C) AMP-activated protein kinase (AMPK) its action mechanism. also decreased lipid droplets lowered expression...

Retrospective study.To determine whether cervical degenerative spondylolisthesis is unstable and/or progresses.Cervical relatively common in the elderly. However, there are no reports regarding its natural history.We identified 27 patients with (3.9%) from a database of 697 patients, using radiographs. All had neutral and dynamic lateral radiographs at baseline minimum 24 months later (mean 39 mo, range, 24-92 mo). The mean age initial visit was 59.0 years (range, 50-83 yr). Male to female...

In this study, we investigated the potential anticancer effects of Viscum album, a parasitic plant that grows on Malus domestica (VaM) breast cancer cells, and explored underlying mechanisms. VaM significantly inhibited cell viability proliferation induced apoptosis in dose-dependent manner. also regulated cycle progression effectively activation STAT3 signaling pathway through SHP-1. Combining with low-dose doxorubicin produced synergistic effect, highlighting its as promising therapeutic....

The cervical spine plays a critical role in supporting the skull, maintaining horizontal gaze, and facilitating walking. Its unique characteristics, including widest range of motion among spinal segments, have led to extensive research on sagittal alignment. Various parameters been proposed evaluate alignment, with studies investigating their clinical significance, correlation symptoms, implications for surgical interventions. Recent findings suggest that alignment not only impacts but also...