Objective: This study aimed to compare the efficacy and safety of romosozumab, a bone anabolic agent, versus vertebroplasty, conventional surgical intervention, in treating osteoporotic vertebral compression fractures (OVCFs).Methods: A retrospective analysis included 86 thoracic/lumbar fracture patients from 2014 2022 at medical center. Forty-two received romosozumab (monthly injections for 1 year) followed by year denosumab, while 44 underwent vertebroplasty denosumab biannually 2 years....

<h3>Aims</h3> To evaluate changes in the corneal endothelial cell density (ECD) and decompensation following Ahmed glaucoma valve (AGV) implantation. <h3>Methods</h3> This study was retrospective observational case series. Patients with refractory who underwent AGV implantation were followed &gt;5 years consecutively enrolled. We reviewed medical records, including results of central specular microscopy. Of 127 enrolled patients, annual change ECD (%) determined using linear regression for...

Stem cells are unique cell populations with the ability to undergo both self-renewal and differentiation, although a wide variety of adult stem as well embryonic have been identified plasticity has recently reported. To identify genes implicated in control state characteristics each line, we analyzed expression profiles human embryonic, hematopoi- etic (CD34+ CD133+), mesenchymal using cDNA microarrays, that were differentially expressed specific populations. In particular able potential...

Objectives The objectives of this study were to compare the variations bone density in midfacial bones as measured by computed tomography (CT) scans between osteoporosis and control groups evaluate regions that facial trauma iatrogenic problem often occur midface. Methods 96 patients who underwent both osteomeatal unit CT dual-energy x-ray absorptiometry at our hospital included retrospectively. Seven skeletal chosen for evaluation: group A (orbital floor, nasal bone), B (zygomaticomaxillary...

Objective Steroids have been widely used to treat inner‐ear diseases such as sudden sensorineural hearing loss, tinnitus, and Meniere's disease. They can be given via either systemic or intratympanic (IT) injection. The purpose of the present study was explore differences in intracochlear steroid distribution by administration method employed (systemic vs. IT injection). Study Design Animal study. Methods Twenty‐three Sprague‐Dawley rats were fluorescein isothiocyanate‐labeled dexamethasone...

The purpose of this study is to investigate cross-reactivity between hypertonic saline-treated decellularized porcine corneal lamellae for xenobridging and subsequent allotransplants. Five Chinese rhesus macaques, which had undergone anterior partial thickness transplantation using in preceding experiments, were used as recipients full-thickness allografts. To determine whether sensitization xenoantigens leads against alloantigens, we compared; (i) allogeneic one-way mixed lymphocyte...

&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To investigate the time course of tinnitus changes in patients receiving cochlear implantation (CI) a prospective, multicenter setting and to determine related factors. &lt;b&gt;&lt;i&gt;Materials Methods:&lt;/i&gt;&lt;/b&gt; A total 79 adult who underwent CI were included this study. We used same questionnaires sequentially 5 times. The Visual Analog Scale (VAS) for severity, Tinnitus Handicap Inventory (THI), Beck's Depression Index (BDI),...

Cervical spondylotic myelopathy (CSM) is one of the most common causes spinal cord impairment in elderly patients. However, a consensus has yet to be reached on ideal method surgical intervention. In this study, we investigated serial changes radiological findings after three-level anterior cervical discectomy and fusion (ACDF) multilevel laminoplasty attempted identify parameters affecting long-term clinical outcomes CSM.Of 152 patients with CSM treated ACDF laminoplasty, 42 had complete...

The authors report two cases of X-linked juvenile retinoschisis (XLRS) manifested as bilateral vitreous hemorrhage early in an 1-month-old infant and a 3-month-old infant. one-month-old male showed massive hemorrhage. During vitrectomy, thin membrane representing inner part schisis cavity was excised intraschisis evacuated. As cavities were cleared, the stump layer appeared demarcation line between outer retina non-schisis retina. other three-month-old presenting with esodeviation also...

Objective: Acute subdural hematoma (ASDH) patients are treated conservatively or surgically according to the guidelines for surgical treatment.Many with thin ASDH and mild neurologic deficit managed conservatively, but sometimes aggravation of chronic (CSDH) results in exacerbated clinical symtoms consequently requires surgery.The aim this study is evaluate risk factors that indicate progression initially non-operated CSDH.Methods: We divided 177 patients, presenting (managed initially)...

Purpose: To elucidate the learning curve for endoscopic endonasal dacryocystorhinostomy (EE-DCR) based on results of EE-DCR performed by three surgeons at different tertiary hospitals.Methods: A retrospective review medical records 386 eyes 337 patients who had undergone hospitals and were available a >6-month postoperative observation period was conducted.The success given surgery determined test during patient's last outpatient visit to hospital.The identified dividing into four groups...

Purpose: To investigate the immediate and long-term outcomes of Ahmed glaucoma valve (AGV) implantation with silicone tube ligation removable external stents.Methods: This retrospective non-comparative study investigated AGV stents in 95 eyes (90 patients) at least 12 months postoperative follow-up.Qualified success was defined as an intraocular pressure (IOP) ≤21 mmHg ≥6 regardless anti-glaucoma medication.Those who required additional surgery, implant removal or had phthisis bulbi were...

Abstract Background To establish the consensus about conditions for undertaking clinical trials in xenocorneal transplantation K orea, specific issues regarding on ethical and regulatory aspects are addressed, guidelines to conduct trial of proposed. Method Results Chapter 1 reviews key requirements progress a orean framework transplantation. Chapters 2–7 provide recommendations source pigs, quality control porcine corneal procurement, preclinical efficacy required justify trial, strategies...

Intralabyrinthine schwannomas (ILSs) are rare benign tumors arising from the distal part of cochleovestibular nerve confined within labyrinth. Patients with ILSs complain hearing loss, vertigo, tinnitus, and ear fullness. Surgical treatment ILS is performed in special cases such as patients nonserviceable hearing, progressive intractable or tumor extension. We present an unusual case a patient intralabyrinthine schwannoma who underwent surgery to treat loss recovered his after surgery....

Gap junction coupling is known to play a role in intercellular communication by the Good Samaritan effect or bystander effect. Nonjunctional connexins (Cxs) may also certain gap junction-independent roles cell death survival. The purpose of present study was investigate junctional and nonjunctional Cxs ototoxic drug-induced auditory focusing on Cx43 cochlea.Nonjunctional conditions were prepared low confluence culture (5 × 103/cm2) trafficking inhibitor, brefeldin A (BFA), cells, short...

Abstract Shortage of donor cornea is a significant problem in Asia, and xenocorneal transplantation being actively studied to alleviate this problem. However, the attitudes subjects who await corneal transplants toward are not known at all. Thus, study aimed investigate on waiting lists for transplants, xenotransplantation. A telephone questionnaire survey comprising six items was conducted 132 among wait‐listed individuals (n = 590) were awaiting or had undergone Seoul National University...

purpose. To describe a previously unreported overlapping trajectory of retinal nerve fibers over other in the horizontal plane, and to report on incidence this anatomic variation. methods. This study included 1410 eyes 1018 subjects with one or more localized fiber layer (RNFL) defects detected by using red-free fundus photography. All photographs were reviewed, plane selected. Overlapping defined as nonparallel adjacent fibers, according photographs. results. was 33 30 subjects. The...

Neuromuscular disorders (NMDs) are diseases involving the upper and lower motor neurons muscles. In patients with NMDs, cervical spinal deformities a very common issue; however, unlike thoracolumbar deformities, few studies have investigated these disorders. The NMDs irregular curvature caused by poor balance coordination of their head, neck, trunk. Particularly, deformity occurs at younger age, is known to show more rigid severe high levels. Muscular physiologic dynamic characteristics such...

Retrospective multicenter study.To evaluate the surgical outcomes of cervical ossification posterior longitudinal ligament (OPLL) in diabetes mellitus (DM) patients.Approximately 253 OPLL patients who underwent decompression with or without fixation were registered at 4 institutions 3 Asian countries. They followed up for least 2 years. Demographics, imaging, and information collected, Japanese Orthopaedic Association (JOA) scores visual analog scale (VAS) neck used evaluation.Forty-seven...