A5100659886- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
- Mesenchymal stem cell research
- Medical Imaging and Analysis
- Scoliosis diagnosis and treatment
- Anesthesia and Pain Management
- Pelvic and Acetabular Injuries
- Nerve injury and regeneration
- Management of metastatic bone disease
- Neurofibromatosis and Schwannoma Cases
- Spinal Cord Injury Research
- Spinal Hematomas and Complications
- Glioma Diagnosis and Treatment
- Nerve Injury and Rehabilitation
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Bone health and osteoporosis research
- Cancer, Hypoxia, and Metabolism
- Anesthesia and Neurotoxicity Research
- Vascular Malformations Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Bone Tissue Engineering Materials
- Parkinson's Disease and Spinal Disorders
Yonsei University
2015-2024
Severance Hospital
2015-2024
Weatherford College
2022
Korea Institute of Oriental Medicine
2022
First Affiliated Hospital of Nanchang University
2018
Nanchang University
2018
National Research Foundation of Korea
2018
Sichuan Mianyang 404 Hospital
2018
Lehigh University
2018
Peking University Shenzhen Hospital
2018
In Brief Study Design. Retrospective study of the difference heterotopic ossification (HO) occurrence according to 3 different types prosthesis. Objective. This was designed investigate HO type Summary Background Data. is defined as formation bone outside skeletal system. Reported rate in cervical artificial disc replacement (ADR) unexpectedly high and varied. But influencing factors ADR have not been elucidated well. The prosthesis-related for making were investigated this study. Methods. A...
In a phase I/IIa open-label and nonrandomized controlled clinical trial, we sought to assess the safety neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into injured cord after traumatic cervical spinal injury (SCI). Of 19 treated subjects, 17 were sensorimotor complete 2 motor sensory incomplete. hNSPCs derived from fetal telencephalon grown as neurospheres cord. control group, who did not receive cell implantation but otherwise closely matched with...
Pelvic reconstruction after sacral resection is challenging in terms of anatomical complexity, excessive loadbearing, and wide defects.Nevertheless, the technological development 3D-printed implants enables us to overcome these difficulties.Here, we present a case osteosarcoma surgically treated with hemisacrectomy using implant.The implant was printed as customized titanium prosthesis from 3D real-sized patient's CT images.It consisted mostly porous mesh incorporated dense strut.After...
We report a series of epidural hematomas which cause neurologic deterioration after spinal surgery, and have taken risk factors prognostic into consideration.We retrospectively reviewed the database 3720 cases spine operation in single institute over 7 years (1998 April-2005 July).Nine patients who demonstrated surgery required surgical decompression were identified.Factors postulated to increase postoperative hematoma improve outcome investigated.The incidence was 0.24%.Operation sites...
A prospective analysis.The purpose of this study was to compare the clinical and radiologic outcomes cervical artificial disc replacement (C-ADR) combined with anterior discectomy fusion (ACDF) 2-level ACDF in patients disease.Adjacent segment degeneration is a long-term complication ACDF, estimated affect 25% within 10 years initial surgery. Two-level leads substantially greater increase intradiscal pressure than one-level fusion. It has been demonstrated that C-ADR maintains motion at...
Object The objective of this study was to evaluate the invasiveness microendoscopic discectomy (MED) in comparison with microscopic (MD) by measuring serum levels creatine phosphokinase (CPK)-MM and lactate dehydrogenase (LDH)-5, comparing visual analog scale (VAS) scores postoperative pain. Methods This included a group 15 patients who underwent surgery using MED MD, both for single-level unilateral herniated nucleus pulposus. CPK-MM LDH-5 were measured at admission after 1, 3, 5 days...
A prospective, randomized, controlled, and double-blind trial.To evaluate the effects of 2 different doses perioperative pregabalin administration, twice on day surgery, acute postoperative pain after spinal surgery.Besides its well-established role neuropathic pain, seems to be a promising adjunct multimodal analgesic regimen following surgery. No comprehensive data exist regarding optimal dosage reducing opioid consumption in surgery.Patients were randomly assigned 1 3 groups. The placebo...
The goal of this study was to determine the relationship between cervical spine sagittal alignment and clinical outcomes after laminoplasty in patients with ossification posterior longitudinal ligament (OPLL).Fifty consecutive who underwent a for OPLL January 2012 2013 were followed up at least 1 year analyzed study. Standing plain radiographs spine, CT (midsagittal view), MRI (T2-weighted view) obtained (anteroposterior, lateral, flexion, extension) pre- postoperatively. Cervical assessed...
Abstract BACKGROUND Spinal cord glioma grade IV is a rare, diffuse midline glioma. H3 K27M-mutant was classified in different entity the 2016 World Health Organization (WHO) classification recently. No reports about prognosis of spinal are available yet. OBJECTIVE To analyze prognostic factors for IV. METHODS Twenty-five patients with who underwent surgery single institute were selected. All histologically confirmed as glioblastoma or “diffuse K27M-mutant” by WHO central nervous system...
Despite current developments in bone substitute technology for spinal fusion, there is a lack of adequate materials regeneration clinical applications. Recombinant human morphogenetic protein-2 (rhBMP-2) commercially available, but severe inflammatory response known side effect. Bone graft substitutes that enhance osteogenesis without adverse effects are needed. We developed bioactive molecule-laden PLGA composite with multi-modulation fusion. This bioresorbable scaffold was considered...
Neuroregeneration and remyelination rarely occur in the adult mammalian brain spinal cord following central nervous system (CNS) injury. The glial scar has been proposed as a major contributor to this failure regenerative process. However, its underlying molecular cellular mechanisms remain unclear. Here, we report that monoamine oxidase B (MAOB)-dependent excessive GABA release from reactive astrocytes suppresses CNS repair by reducing BDNF TrkB expression severe injury (SCI) animal models....
The low survival rate of graft stem cells after transplantation into recipient tissue is a major obstacle for successful cell therapy. After the site spinal cord injury, face not only hypoxia due to oxygen conditions, but also lack nutrients caused by damaged tissues and poor vascular supply. To improve therapeutic grafting injured cord, we examined effects cotransplanting mouse neural (mNSCs) adipose tissue-derived mesenchymal (AT-MSCs) on mNSC viability. viability mNSCs in coculture with...
A retrospective study.To analyze adjacent segment degeneration (ASD) in 2-level anterior cervical discectomy, comparing fusion with stand-alone cages [anterior discectomy and (ACDF)-CA] cage plate constructs (ACDF-CPC) respect to clinical outcomes radiologic changes.ACDF using a or construct is popular procedure. However, there lack of knowledge concerning ASD between the 2 procedures.A total 42 consecutive patients who underwent ACDF-CA ACDF-CPC for disk disease completed years follow-up...
Robot-assisted Resection of Paraspinal SchwannomaResection retroperitoneal tumors is usually perfomed using the anterior approach.Our report presents an innovative method utilizing a robotic surgical system.A 50-yr-old male patient visited our hospital due to known paravertebral mass.Magnetic resonance imaging showed well-encapsulated mass slightly abutting abdominal aorta and left psoas muscle at L4-L5 level.The tumor seemed be originated from prevertebral sympathetic plexus or lumbosacral...
In Brief Study Design. The use of the da Vinci Surgical System to perform an anterior lumbar interbody fusion in a swine model identify technical properties, processes, merits, demerits, and limitations video-assisted robotic surgical system. Objective. This study was designed demonstrate feasibility using system spinal surgery. Summary Background Data. Video-assisted laparoscopic first reported 1995 afterward spotlighted for several years. However, this technique has not become popular...
Study Design: Retrospective study. Objectives: To compare the efficacy of 2-level anterior cervical discectomy and fusion with cage alone (ACDF-CA) plate construct (ACDF-CPC) regard to clinical outcome radiologic changes. Summary Background Data: The use stand-alone interbody cages in ACDF has become popular, but high subsidence rates have been reported literature. Methods: A total 54 consecutive patients who underwent ACDF-CA or ACDF-CPC after suffering from radiculopathy were divided into...