Chang Hyun Oh

ORCID: 0000-0002-8919-1741
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About
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Research Areas
  • Spine and Intervertebral Disc Pathology
  • Spinal Fractures and Fixation Techniques
  • HIV/AIDS drug development and treatment
  • Advanced MRI Techniques and Applications
  • Cervical and Thoracic Myelopathy
  • Medical Imaging Techniques and Applications
  • NMR spectroscopy and applications
  • Musculoskeletal pain and rehabilitation
  • Biochemical and Molecular Research
  • Atomic and Subatomic Physics Research
  • Click Chemistry and Applications
  • Advanced NMR Techniques and Applications
  • Medical Imaging and Analysis
  • Spinal Hematomas and Complications
  • Carbohydrate Chemistry and Synthesis
  • Scoliosis diagnosis and treatment
  • Anesthesia and Pain Management
  • Neurosurgical Procedures and Complications
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Body Contouring and Surgery
  • Pelvic and Acetabular Injuries
  • Synthesis of β-Lactam Compounds
  • Radiation Detection and Scintillator Technologies
  • Antibiotics Pharmacokinetics and Efficacy
  • Spinal Cord Injury Research

Korea Institute of Science and Technology
2004-2024

Chung-Ang University Hospital
2020

Korea University of Science and Technology
2018

Korea Institute of Geoscience and Mineral Resources
2016-2017

Yonsei University
2016

Korea Advanced Institute of Science and Technology
1984-2015

Inha University
2008-2014

Aesthetic Surgery Center
2014

Military Manpower Administration
2011-2013

Inha University Hospital
2012

Pfirrmann disc grade is a useful scoring tool for evaluating degeneration, but normal values according to aging process has not been elucidated. This study was conducted identify the prevalence and pattern of whole spine degeneration ages gender differences.Total 653 patients (336 male 317 female patients, 48.1±58.7 years old) who took magnetic resonance images were enrolled in this study. There 19 cases their 2nd decades 74 3rd decades, 141 4th 129 5th 139 6th 93 7th 58 over 8th decades....

10.14245/kjs.2017.14.4.148 article EN cc-by-nc Korean Journal of Spine 2017-12-31

Abstract Sodium magnetic resonance imaging of the human body in vivo has been tried and its clinical application is considered. A short T 2 algorithm with total volume excitation a specialized RF coil focused to region interest have adopted improve signal‐to‐noise ratio. Using 1.5‐T system, several important organs including heart, liver, gallbladder, kidney, spine examined demonstrate their sodium concentration . © 1988 Academic Press, Inc.

10.1002/mrm.1910070103 article EN Magnetic Resonance in Medicine 1988-05-01

A retrospective study.To analyze adjacent segment degeneration (ASD) in 2-level anterior cervical discectomy, comparing fusion with stand-alone cages [anterior discectomy and (ACDF)-CA] cage plate constructs (ACDF-CPC) respect to clinical outcomes radiologic changes.ACDF using a or construct is popular procedure. However, there lack of knowledge concerning ASD between the 2 procedures.A total 42 consecutive patients who underwent ACDF-CA ACDF-CPC for disk disease completed years follow-up...

10.1097/bsd.0b013e3182a355ad article EN Journal of Spinal Disorders & Techniques 2013-07-27

The purpose of this study was to develop a dual-modality positron emission tomography (PET)/magnetic resonance imaging (MRI) with insertable PET for simultaneous and MR the human brain.The detector block composed 4 × matrix modules, each consisting array LYSO coupled Geiger-mode avalanche photodiode (GAPD) array. insert consisted 18 blocks, circularly mounted on custom-made plastic base form ring an inner diameter 390 mm axial length 60 mm. gantry shielded gold-plated conductive fabric tapes...

10.1118/1.4918321 article EN Medical Physics 2015-04-16

BRAF is an important component of MAPK cascade. Mutation BRAF, in particular V600E, leads to hyperactivation the pathway and uncontrolled cellular growth. Resistance selective inhibitors mutated a major obstacle against treatment many cancer types. In this work, series new (imidazo[2,1-b]thiazol-5-yl)pyrimidine derivatives possessing terminal sulfonamide moiety were synthesized. Pan-RAF inhibitory effect was investigated, structure–activity relationship discussed. Antiproliferative activity...

10.1021/acs.jmedchem.1c00230 article EN Journal of Medicinal Chemistry 2021-05-17

A new and highly convenient Au-catalyzed cyclization of alkyne-propargylic acetates leading to 2-acyl-3-arylnaphthalene derivatives is described; these are possible candidates for light-emitting materials.

10.1055/s-2006-950273 article EN Synlett 2006-10-01

Objective The authors prospectively analyzed the effect of one-level or two-level anterior cervical discectomy and fusion (ACDF), comparing stand-alone cages cage-with-plate fixation constructs with respect to clinical outcomes radiologic changes. Methods A total 84 patients who underwent (n=52) ACDF (n=32) for disc disease completed 2 years follow-up were included in this study. divided by level grouped into ACDF-Cage-only ACDF-Cage-with-plate groups. following parameters assessed using...

10.3340/jkns.2017.0211 article EN cc-by-nc Journal of Korean Neurosurgical Society 2017-10-26

Objective A variety of different pedicle screws entry point techniques are used for the lumbar placement. This study reported Kim's with free hand technique and accuracy this technique. Methods We retrospectively reviewed 584 cases placed screw The diagnosis included 491 degenerative spine, 59 trauma, 29 metastatic disease, 5 scoliosis. total 2601 were placed, points junction proximal edge transverse process lamina. Incidence extent cortical breach by misplaced was determined review...

10.14245/kjs.2013.10.1.7 article EN cc-by-nc Korean Journal of Spine 2013-01-01

The present work describes the design and synthesis of a novel series 1,3-diaryl-4-sulfonamidoarylpyrazole derivatives 1a-q 2a-q their in vitro biological activities. target compounds were evaluated for antiproliferative activity against NCI-60 cell line panel. Compounds 1c, 1g, 1k-m, 1o, 2g, 2h, 2k-m, 2o, 2q showed highest mean inhibition percentages at 10 µM single-dose testing selected to be tested 5-dose mode. ICs50 most potent determined over 60 lines. Compound 2l exhibited strongest...

10.1080/14756366.2018.1530225 article EN cc-by Journal of Enzyme Inhibition and Medicinal Chemistry 2018-10-26

Postoperative pain is one of the major complaints patients after lumbar fusion surgery. The authors evaluated effects intravenous patient controlled analgesia (IV-PCA) using fentanyl or sufentanil on postoperative management and pain-related complications.Forty-two that had undergone surgery with instrumentation at single double levels constituted study cohort. Patients were equally randomly allocated to a group (group S) F) for (PCA). Group S received dose 4 μg/kg IV-PCA F 24 IV-PCA. A...

10.3340/jkns.2016.0707.007 article EN cc-by-nc Journal of Korean Neurosurgical Society 2016-12-29

Objective The purpose of this study was to compare the radiological and neurological outcomes between two atlantoaxial fusion method for stabilization; C1 lateral mass-C2 pedicle screws (screw-rod constructs, SRC) versus C1-2 transarticular (TAS). Methods Forty-one patients in whom instability treated with fixation by SRC group (27 patients, from March 2005 May 2011) or TAS (14 2000 December 2005) were retrospectively reviewed. Numeric rating scale (NRS) pain assessment, Oswestry disability...

10.3340/jkns.2014.55.5.255 article EN cc-by-nc Journal of Korean Neurosurgical Society 2014-01-01

Line-integral projection reconstruction (LPR) in NMR imaging was found to be useful and has several advantages such as the capability of objects having short T2 compensation phase fluctuations arising from system instability. Although single slice LPR is inefficient poor signal-to-noise ratio (SNR), multislice encoded method interest since it a high SNR also selected regional volume or imaging. The latter, i.e., capability, unique property offers variety capabilities simultaneous sagittal,...

10.1109/tmi.1984.4307677 article EN IEEE Transactions on Medical Imaging 1984-12-01

second operation : shunt after cranioplasty or shunt, † 6 months later means the operation.GCS Glasgow Coma Scale

10.3340/jkns.2008.44.4.211 article EN cc-by-nc Journal of Korean Neurosurgical Society 2008-01-01

Prospective study.The purpose of this study was to compare the long-term clinical and radiologic outcomes hybrid surgery (HS) 2-level anterior cervical discectomy fusion (2-ACDF) in patients with disk disease.In a previous 2-year follow-up, HS shown be superior 2-ACDF, better Neck Disability Index (NDI) score, less postoperative neck pain, faster C2-C7 range motion (ROM) recovery, adjacent ROM increase.Between 2004 2006, 40 undergoing at our hospital were identified as degenerative disease....

10.1097/bsd.0000000000000316 article EN Clinical Spine Surgery A Spine Publication 2015-08-20

Objective: Decompressive craniectomy (DC) is a useful surgical method to achieve adequate decompression in hypertensive intracranial patients.This study suggested new skin incision for DC, and analyzed its efficacy safety.Methods: In the retrograde reviews, 15 patients underwent newly approach using n-shape technique (Group A) 23 were treated with conventional question mark B).Two groups compared terms of decompressed area craniectomy, protruded brain volume out skull layer, operation time...

10.13004/kjnt.2016.12.2.72 article EN Korean Journal of Neurotrauma 2016-01-01

To investigate the prevalence of paralytic ileus after spinal operation in supine or prone operative position and to determine efficacy prophylactic gastrointestinal motility medications preventing symptomatic a operation.All patients received surgery position. The study period was divided into two phases: first, analyze radiographic operation, second, therapeutic effects (postoperative intravenous injection scopolamine butylbromide metoclopramide hydrochloride) on operation.Basic...

10.3349/ymj.2015.56.6.1627 article EN cc-by-nc Yonsei Medical Journal 2015-01-01

CYSTS OF the mesentery are rare and chylous cysts extremely rare, so that experience of any one surgeon or institution with this condition is necessarily limited. The history symptoms usually varied not characteristic; physical roentgenologic findings, although suggestive, never pathognomonic. Consequently, diagnosis regularly made at time abdominal exploration postmortem examination. This report describes two cases mesenteric observed Mount Sinai Hospital City Center Elmhurst, NY, in recent...

10.1001/archsurg.1967.01330120044009 article EN Archives of Surgery 1967-06-01

Purpose: Percutaneous epidural neuroplasty (PEN) is a minimally invasive treatment.The efficacy of PEN has been relatively well investigated; however, the relationship between clinical effectiveness and severity spinal canal stenosis by disc material not yet established.The purpose this study was to compare outcomes according dural sac cross-sectional area in single level disease.Materials Methods: This included 363 patients with back pain from disease without radiculopathy.Patients were...

10.3349/ymj.2015.56.3.691 article EN cc-by-nc Yonsei Medical Journal 2015-01-01

Purpose: Clinical outcomes and radiologic results after cervical arthroplasty have been reported in many articles, yet relatively few studies conducted severe degenerative disc disease.Materials Methods: Sixty patients who underwent (Mobi-C ® ) between April 2006 November 2011 with a minimum follow-up of 18 months were enrolled this study.Patients divided into two groups according to Pfirrmann classification on preoperative MR images: group A (Pfirrmann grade III, n=38) B grades IV or V,...

10.3349/ymj.2014.55.4.1072 article EN cc-by-nc Yonsei Medical Journal 2014-01-01

Cryolipolysis, a preferred method for minimally invasive body contouring, involves the noninvasive cooling of adipocytes to induce lipolysis without damaging other tissues. This study aimed evaluate safety and efficacy cryolipolysis treatment excessive fat tissue.Between May 2014 December 2017, 231 patients with 448 areas interest were enrolled their records retrospectively reviewed. We used five different vacuum applicators, best-fitting applicator was each area. One cycle applied at...

10.5999/aps.2019.01305 article EN cc-by-nc Archives of Plastic Surgery 2020-01-01

A general orientation along the cervical spine could be estimated by external landmarks, and it was useful, quick less exposable to radiation, but, sometimes gave reference confusion of target level. The authors reviewed corresponding between neck landmarks levels.Totally 1,031 lateral radiographs different patients were in single university hospital. Its compositions 534 males 497 females; 86 second decades (10-19 years-old), 169 third decades, 159 fourth 209 fifth 275 sixth 133 more than...

10.14245/kjs.2014.11.3.178 article EN cc-by-nc Korean Journal of Spine 2014-01-01
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