A5053964263- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Sodium Intake and Health
- Cardiovascular Disease and Adiposity
- Renin-Angiotensin System Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Pressure and Hypertension Studies
- Stress Responses and Cortisol
- Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Streptococcal Infections and Treatments
- Esophageal and GI Pathology
- Cell Adhesion Molecules Research
- Peroxisome Proliferator-Activated Receptors
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Signaling Pathways in Disease
- Diet and metabolism studies
- Esophageal Cancer Research and Treatment
- Diet, Metabolism, and Disease
- Metastasis and carcinoma case studies
- Neonatal and Maternal Infections
- Gastrointestinal Tumor Research and Treatment
- Bacterial Identification and Susceptibility Testing
Higashihiroshima Medical Center
2020-2023
Hiroshima University
2015-2021
Toho University
2021
Toho University Omori Medical Center
2021
Japanese Red Cross Nagoya Daiichi Hospital
2016-2018
Nagoya University
2010-2015
Nagoya City University
2013
GlaxoSmithKline (Netherlands)
2012
Teikyo University
1999-2008
Calorie restriction (CR) can modulate the features of obesity-related metabolic and cardiovascular diseases. We have recently characterized DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, derived from a cross between Dahl salt-sensitive Zucker as new animal model syndrome. DS/obese rats develop hypertension manifest left ventricular remodeling diastolic dysfunction, well increased cardiac oxidative stress inflammation. now investigated effects CR on pathophysiology in rats. were fed either normal...
Background Metabolic syndrome (MetS) enhances salt sensitivity of blood pressure and is an important risk factor for cardiovascular disease. The effects dietary restriction on cardiac pathology associated with metabolic remain unclear. Methods Results We investigated whether might ameliorate injury in DahlS.Z‐ Lepr fa / ( DS /obese) rats, which are derived from a cross between Dahl salt‐sensitive Zucker rats represent model syndrome. /obese were fed normal‐salt (0.36% NaCl chow) or low‐salt...
Restraint stress stimulates sympathetic nerve activity and can affect adiposity metabolism. However, the effects of restraint on cardiovascular metabolic disorders in syndrome (MetS) have remained unclear. We investigated chronic β-adrenergic receptor (β-AR) blockade cardiac adipose tissue pathology a rat model MetS. DahlS.Z- Lepr fa / (DS/obese) rats, derived from cross between Dahl salt-sensitive Zucker rats. Rats were exposed to (restraint cage, 2 h/day) for 4 wk 9 age with or without...
The L/N-type calcium channel blocker (CCB) cilnidipine suppresses sympathetic nerve activity and has a superior renoprotective effect compared with L-type CCBs such as amlodipine. cardioprotective action of remained largely uncharacterized, however. We have now investigated the effects cilnidipine, in comparison amlodipine, on cardiac pathophysiology rats salt-sensitive hypertension.Dahl fed high-salt diet from 6 weeks age were treated vehicle (LVH group), amlodipine (3 mg/kg per day), or...
Tumor necrosis factor (TNF)-α reportedly has key pro-inflammatory properties in both atherosclerosis and adipocytes. To further investigate the biologic impact of epicardial adipose tissue (EAT) on coronary atherosclerosis, we evaluated relationship between TNF-α gene expression EAT clinically-assessed computed tomography (CT).We studied 47 patients before cardiac surgery (coronary artery bypass grafting [CABG], n=26; non-CABG, n=21), assessing visceral (VAT) area, volume, calcium score...
Colorectal cancer ( CRC ) is one of the leading causes cancer‐related death worldwide. In order to identify novel prognostic markers or therapeutic targets for , we searched candidate genes in our comprehensive gene expression libraries, and focused on SEC 11A which encodes SPC 18 protein. plays a key role endoplasmic reticulum‐Golgi secretory pathway presumably regulates secretion various proteins. An immunohistochemical analysis 137 tissue samples demonstrated that 79 (58%) cases were...
Aims Gastric cancer ( GC ) is one of the leading causes cancer‐related death worldwide. Genes expressed only in tissue may be useful biomarkers for diagnosis and therapeutics. The aims present study were to analyse regulator calcineurin 2 RCAN 2) a large number s, investigate how these expression patterns correlate with clinicopathological parameters various markers. Methods results An immunohistochemical analysis 207 samples showed that 110 (53%) s positive 2. 2‐positive more advanced terms...