A5091898524- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- Cancer Genomics and Diagnostics
- Urological Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Treatments and Mutations
- Urologic and reproductive health conditions
- Multiple and Secondary Primary Cancers
- MicroRNA in disease regulation
- Musculoskeletal pain and rehabilitation
- Circular RNAs in diseases
- RNA modifications and cancer
- Fibroblast Growth Factor Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Spinal Fractures and Fixation Techniques
- Abdominal Surgery and Complications
Hiroshima University
2016-2025
Tokyo Metropolitan Komagome Hospital
2024-2025
Shizuoka Cancer Center
2025
Osaka International Cancer Institute
2025
Hyogo Prefectural Cancer Center
2025
Noguchi Hospital
2021-2025
Tohoku University
2024
Sapporo Minami Hospital
2021-2024
Cancer Center of Hawaii
2017-2023
University of Hawaii System
2017-2023
We hypothesized that four criteria could help identify malignant mesotheliomas (MMs) most likely linked to germline mutations of BAP1 or other genes: family history MM, BAP1-associated cancers, multiple malignancies; age younger than 50 years.
Significance Millions of people have been exposed to asbestos and are at increased risk developing mesothelioma, an aggressive malignancy resistant current therapies. Here, we elucidate critical steps in carcinogenesis: induces the release high mobility group box 1 that triggers autophagy. Autophagy activation constitutes a key biological process allows some mesothelial cells survive cytotoxicity consequently increases fraction DNA-damaged human susceptible malignant transformation. We found...
Objective This study evaluated whether first‐line treatment affects survival outcomes in patients with advanced urothelial carcinoma undergoing sequential therapy chemotherapy, immune checkpoint inhibitors, and enfortumab vedotin. Methods multicenter retrospective included 57 treated at Hiroshima University Hospital its affiliated institutions between 2009 2024. Patients received chemotherapy as a (gemcitabine plus cisplatin or carboplatin), followed by second‐line inhibitors (pembrolizumab...
We describe the electrochemical detection of DNA methylation through direct oxidation both 5-methylcytosine (mC) and cytosine (C) in 5'-CG-3' sequence (CpG) oligonucleotides using a sputtered nanocarbon film electrode after digesting longer CpG oligonucleotide with endonuclease P1. Direct electrochemistry was insufficient for obtaining currents these bases because CG rich inhibited each base oligonucleotides, owing to conformational structure its very low diffusion coefficient. To detect C...
This study aimed to assess the prognostic outcomes in mRCC patients receiving second-line TKI following first-line IO combination therapy.
Recent studies have reported that TUBB3 overexpression is involved in docetaxel (DTX) resistance prostate cancer (PCa). The aim of this study was to clarify the role DTX and cabazitaxel (CBZ) resistance, cross-resistance between CBZ PCa. We analyzed effect knockdown on examined interaction PTEN. also investigated phosphoinositide 3-kinases (PI3K) inhibitor (LY294002) resistance. expression upregulated DTX-resistant CBZ-resistant cells. re-sensitized cells CBZ. Additionally, cell lines CBZ,...
Significance We found that the probability of carrying heterozygous germline BLM mutations is significantly higher among mesothelioma patients than in general population. In vitro and vivo experiments suggest increase susceptibility to mesothelioma. -mutation carriers are at risk developing mesothelioma, their increases upon asbestos exposure. Therefore, mutation should benefit from prevention screening for early detection. genetic testing identify counseling would help individuals provide...
Background/Objectives: It is said that genes escape from X chromosome inactivation (XCI) contribute to gender differences. We analyzed the prognostic role of these and identified a gender-biased difference in prognosis according KDM6A mutation immune therapy cohort (IMvigor 210). also investigate differential effect several public databases urothelial carcinoma (UC). Methods: used AACR GENIE, The Cancer Genome Atlas, International Consortium, related therapy, chemotherapy, BCG treatment....
Abstract Objective To validate multiple prognostic models in metastatic renal cell carcinoma patients who received second-line axitinib following first-line nivolumab plus ipilimumab therapy. Methods Five (ACL, albumin, C-reactive protein, and lactate dehydrogenase; IMDC, International Metastatic Renal Cell Carcinoma Database Consortium; MSKCC, Memorial Sloan Kettering Cancer Center; ATP, treatment prediction; JMRC, Japanese cancer) to predict overall survival (OS) were validated compared...
Chronic kidney disease (CKD) is a risk factor for bladder cancer (BC) and reportedly involved in its recurrence progression. This study aimed to determine the molecular mechanisms underlying development of BC patients with CKD. First, we generated CKD mouse model according unilateral two-stage renal ischemia-reperfusion injury protocol using wild-type C57BL/6 mice. Second, conducted functional analysis DGKα investigated contribution cell invasion, migration, proliferation activity human...
Transanal total mesorectal excision is a useful technique while performing lower rectal cancer and deep pelvic surgery. However, it relatively difficult procedure, unique complications such as urethral injury have been reported. Although there few reports on visualization, we investigated whether possible to visualize the urethra using fluorescent catheter. We retrospectively examined background short-term surgical outcomes in 17 patients who, between April 2022 December 2023, underwent...
NUT carcinoma is a rare malignant neoplasm characterised by recurrent NUTM1 rearrangements, initially reported in the midline. Recently, 10 cases of cutaneous with adnexal differentiation harbouring BRD3::NUTM1, NSD3::NUTM1, BRD4::NUTM1 or BRD3::NUTM2B fusions have been reported. Accordingly, 'NUT carcinoma' (NAC) has introduced as provisional tumour entity to fifth edition WHO Classification Skin Tumours. We report histopathological, molecular genetic and epigenetic features seven...
The purpose of this study was to analyze the effect lumbar spine fusion on superior adjacent intervertebral disk in context degeneration, using a nonlinear three-dimensional finite element method. Detailed L3-L5 motion segment models normal and degenerated disks were developed. In models, L4-L5 fixed by either posterolateral or posterior interbody (PLIF). Various loading conditions such as compression loading, plus flexion moment extension applied corresponding stress. Tresca stress part...
Fibroblast growth factor (FGF) signaling pathways have been reported to play important roles in prostate cancer (PCa) progression. FGF19 is one of a subfamily FGFs that circulate serum and act an endocrine manner. Our objective was investigate its role the progression PCa.The effect on proliferation epithelial-mesenchymal transition LNCaP PC3 cells examined using MTT assay Western blotting. Serum concentration measured by ELISA 209 patients with PCa, association between clinicopathological...
To assess the long-term outcomes of transrectal high-intensity focused ultrasound (HIFU) for patients with localized prostate cancer.From May 2003 to present, 137 consecutive T1-2 cancer were treated using Sonablate 500 and then followed more than 12 months after their last HIFU treatment. A biopsy was routinely carried out at 6 serum prostate-specific antigen (PSA) measured every 3 HIFU. Oncological as well treatment-related complications assessed. Disease-free survival (DFS) judged Phoenix...
<b><i>Objective:</i></b> Colorectal cancer (CRC) develops through the deregulation of gene expression and accumulation epigenetic abnormalities, leading to tumor cell acquisition malignant features. MicroRNAs (miRNAs) play a critical role in development, where they can act as oncogenes or oncosuppressors. <b><i>Methods:</i></b> miR-148a was measured by qRT-PCR patients with colorectal adenoma (n = 21) CRC (stage I-IV, n 159) using...
To improve the prediction of outcomes in patients who will undergo radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), we examined preoperative prognostic factors and established a risk classification model.A total 148 underwent RNU without history neo-adjuvant chemotherapy between 1999 2016 Hiroshima University Hospital were retrospectively reviewed. Associations preoperative/clinicopathological including cancer-specific survival (CSS) recurrence-free (RFS)...