A5026745464- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal-Catalyzed Oxygenation Mechanisms
- Metal complexes synthesis and properties
- Metalloenzymes and iron-sulfur proteins
- Magnetism in coordination complexes
- Oxidative Organic Chemistry Reactions
- Crystallography and molecular interactions
- Myasthenia Gravis and Thymoma
- Porphyrin and Phthalocyanine Chemistry
- Soybean genetics and cultivation
- Catalytic C–H Functionalization Methods
- Peripheral Neuropathies and Disorders
- Synthesis and Catalytic Reactions
- Seed and Plant Biochemistry
- CO2 Reduction Techniques and Catalysts
- Agronomic Practices and Intercropping Systems
- Electrocatalysts for Energy Conversion
- Organometallic Complex Synthesis and Catalysis
- Rice Cultivation and Yield Improvement
- Crop Yield and Soil Fertility
- Polyoxometalates: Synthesis and Applications
- Chemical Synthesis and Reactions
- Microbial metabolism and enzyme function
- Vanadium and Halogenation Chemistry
Osaka University
2016-2025
Shionogi (Japan)
2018-2025
Toho University Ohashi Medical Center
2004-2024
Toho University
2014-2024
Futaba (Japan)
2018-2024
Graduate School USA
2014-2020
Ehime University
2000-2019
Matsuyama University
2019
Suita Municipal Hospital
2017
Osaka City University
2002-2016
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTcis-μ-1,2-Peroxo Diiron Complex: Structure and Reversible OxygenationTakaharu Ookubo, Hideki Sugimoto, Toshihiko Nagayama, Masuda, Takahisa Sato, Koji Tanaka, Yonezo Maeda, Hisashi Ōkawa, Yoshihito Hayashi, Akira Uehara, Masatatsu SuzukiView Author Information Department of Chemistry, Faculty Science Kanazawa University, Kakuma-machi 920-11, Japan Applied Engineering Nagoya Institute Technology Showa-ku, 466, X-ray Research Institute, Rigaku...
Selective hydroxylation of benzene to phenol has been achieved using H2O2 in the presence a catalytic amount nickel complex [NiII(tepa)]2+ (2) (tepa = tris[2-(pyridin-2-yl)ethyl]amine) at 60 °C. The maximum yield was 21% based on without formation quinone or diphenol. In an endurance test catalyst, 2 showed turnover number (TON) 749, which is highest value reported date for molecular catalysts with H2O2. When toluene employed as substrate instead benzene, cresol obtained major product 90%...
Mononuclear copper(II)-superoxo complexes 2(X)-OO(*) having triplet (S = 1) ground states were obtained via reaction of O(2) with the copper(I) starting materials 1(X) supported by tridentate ligands L(X) [1-(2-p-X-phenethyl)-5-(2-pyridin-2-ylethyl)-1,5-diazacyclooctane; X CH(3), H, NO(2)] in various solvents. The superoxo mimic structure [tetrahedral geometry an end-on (eta(1))-bound O(2)(*-)] and aliphatic C-H bond activation chemistry peptidylglycine alpha-hydroxylating monooxygenase...
A mononuclear copper(II) superoxo species has been invoked as the key reactive intermediate in aliphatic substrate hydroxylation by copper monooxygenases such peptidylglycine α-hydroxylating monooxygenase (PHM), dopamine β-monooxygenase (DβM), and tyramine (TβM). We have recently developed a end-on complex using N-[2-(2-pyridyl)ethyl]-1,5-diazacyclooctane tridentate ligand, structure of which is similar to four-coordinate distorted tetrahedral geometry copper-dioxygen adduct found oxy-form...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, Characterization, and Reversible Oxygenation of .mu.-Alkoxo Diiron(II) Complexes with the Dinucleating Ligand N,N,N',N'-Tetrakis{(6-methyl-2-pyridyl)methyl}-1,3-diamino- propan-2-olateYoshihito Hayashi, Takayuki Kayatani, Hideki Sugimoto, Masatatsu Suzuki, Katsuhiko Inomata, Akira Uehara, Yasuhisa Mizutani, Teizo Kitagawa, Yonezo MaedaCite this: J. Am. Chem. Soc. 1995, 117, 45, 11220–11229Publication Date (Print):November 1,...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDynamic Helicity Inversion by Achiral Anion Stimulus in Synthetic Labile Cobalt(II) ComplexHiroyuki Miyake, Kana Yoshida, Hideki Sugimoto, and Hiroshi TsukubeView Author Information Department of Chemistry, Graduate School Science, Osaka City University, Sumiyoshi-ku, 558-8585, Japan Cite this: J. Am. Chem. Soc. 2004, 126, 21, 6524–6525Publication Date (Web):May 11, 2004Publication History Received17 February 2004Published online11 May...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTime-Programmed Peptide Helix Inversion of a Synthetic Metal Complex Triggered by an Achiral NO3- AnionHiroyuki Miyake, Hiroshi Kamon, Ikuko Miyahara, Hideki Sugimoto, and TsukubeView Author Information Department Chemistry, Graduate School Science, Osaka City University, Sumiyoshi-ku, 558-8585, Japan Cite this: J. Am. Chem. Soc. 2008, 130, 3, 792–793Publication Date (Web):December 28, 2007Publication History Received10 September...
Redox properties of a mononuclear copper(II) superoxide complex, (L)CuII–OO•, supported by tridentate ligand (L = 1-(2-phenethyl)-5-[2-(2-pyridyl)ethyl]-1,5-diazacyclooctane) have been examined as model compound the putative reactive intermediate peptidylglycine α-hydroxylating monooxygenase (PHM) and dopamine β-monooxygenase (DβM) (Kunishita et al. J. Am. Chem. Soc. 2009, 131, 2788–2789; Inorg. 2012, 51, 9465–9480). On basis reactivity toward series one-electron reductants, reduction...
Abstract Background A novel polyene macrolide antifungal, COT-832 was created by SHIONOGI through structurally modifying Amphotericin B(AmB). Invasive fungal infections are commonly treated with antifungal drugs such as azoles, polyenes, and echinocandins; however, their efficacy is limited mortality rates remain high. Therefore, the development of more effective safer needed. AmB available in formulations Fungizone (FGZ), which utilizes a deoxycholic acid formulation, AmBisome (L-AMB),...
A series of tin( ii ) complexes R1 supported by phenylene-1,2-diamido ligands containing a bulky N -substituent TIPT and different aromatic substituents R at the 4,5-positions are synthesised characterised.
Copper(II) complexes 1a and 1b, supported by tridentate ligand bpa [bis(2-pyridylmethyl)amine] tetradentate tpa [tris(2-pyridylmethyl)amine], respectively, react with cumene hydroperoxide (CmOOH) in the presence of triethylamine CH3CN to provide corresponding copper(II) cumylperoxo 2a 2b, formation which has been confirmed resonance Raman ESI-MS analyses using 18O-labeled CmOOH. UV-vis ESR spectra as well DFT calculations indicate that a 5-coordinate square-pyramidal structure involving...
Abstract Reaction of a copper(I) complex supported by sterically demanding tripodal tetradentate ligand, HIPT 3 tren, and O 2 gave mononuclear copper(II) end‐on superoxo complex. Spectroscopic (UV/Vis, resonance Raman, ESR, 1 H‐NMR) DFT studies have been performed. The ‐binding process as well the reaction toward external substrates investigated kinetically to demonstrate unique behavior complex, which may occur result existence hydrophobic core around copper coordination sphere created tren ligand.
For the synthesis of 1,2-diols, cis-1,2-dihydroxylation alkenes catalyzed by osmium(VIII) tetroxide (OsO4) is a powerful method. However, OsO4 quite toxic due to its highly volatile and sublimable nature. Thus, development alternative catalysts for challenging. Our approach involves use nitrogen-based tetradentate ligand, tris(2-pyridylmethyl)amine (tpa), an osmium center develop new catalyst hydrogen peroxide (H2O2) as cheap environmentally benign oxidant. The Os–tpa complex acts very...
A new tridentate N3 ligand (TMG3tach) consisting of cis,cis-1,3,5-triaminocyclohexane (tach) and three N,N,N′,N′-tetramethylguanidino (TMG) groups has been developed to prepare copper complexes with a tetrahedral geometry labile coordination site. Treatment the CuIIX2 (X = Cl Br) gave copper(II)-halide complexes, [CuII(TMG3tach)Cl]+ (2Cl) [CuII(TMG3tach)Br]+ (2Br), structures which have determined by X-ray crystallographic analysis. The exhibit four-coordinate structure C3v symmetry, where...
Nitrene bound biradical active oxidant aminates C–H bond in an intermolecular manner.
Six-coordinate rhodium(III) complexes coordinated by a planar trianionic ligand (L3–) are synthesized. One of the axial positions is occupied chloride (Cl–), bromide (Br–), or iodide (I–), and another position solvent molecule such as acetonitrile (AN), water (H2O), tetrahydrofuran (THF), pyridine (PY) to complete an octahedral center; [RhIII(L3–)(X)(Y)]− (1X/Y; X = Cl–, Br–, I–, Y AN, H2O, THF, PY). Coordination THF ligands metal center rather weak, so that these molecules easily replaced...
A mononuclear copper complex bearing a ‘histidine brace’ is synthesised and characterised as an active-site model of monooxygenases such lytic polysaccharide (LPMOs) particulate methane monooxygenase (pMMO).
BackgroundThere has been no report about outcome of pitavastatin versus atorvastatin therapy in high-risk patients with hypercholesterolemia.MethodsHypercholesterolemic one or more risk factors for atherosclerotic diseases (n = 664, age 65, male 54%, diabetes 76%, primary prevention 74%) were randomized to receive 2 mg/day 332) 10 332). Follow-up period was 240 weeks. The end point a composite cardiovascular death, sudden death unknown origin, nonfatal myocardial infarction, stroke,...
Described herein is the discovery and development of a process to prepare chiral triazinanone R-3 diastereomeric intermediate 5, key intermediates in synthesis cap-dependent endonuclease inhibitor baloxavir marboxil (1), which can suppress replication influenza virus. Chiral was obtained via optical resolution its racemic form rac-3. Diastereomeric 5 by condensation reaction thiepin alcohol 4 using combination T3P MsOH. These reactions were performed successfully on kilogram scale critical...
Introduction: Myasthenia gravis (MG), an immune disorder affecting nerve-muscle transmission, often necessitates tailored therapies to alleviate longitudinal symptom fluctuations. Here, we aimed examine and compare the treatment cycle intervals efficacy of efgartigimod in four patients. This case series mainly offers insights into personalized for patients with MG our facility Japan. Methods: We retrospectively analyzed (2 early-onset, 1 late-onset, seronegative MG, managed oral...