A5103079814- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Neuroscience and Neuropharmacology Research
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Lymphoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Veterinary Orthopedics and Neurology
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Gastrointestinal Tumor Research and Treatment
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Viral-associated cancers and disorders
- Genetic factors in colorectal cancer
- Alcohol Consumption and Health Effects
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Neurogenesis and neuroplasticity mechanisms
- Gallbladder and Bile Duct Disorders
- Head and Neck Anomalies
Aichi Cancer Center
2015-2025
Shimizu (Japan)
2023
Gifu University
1999-2023
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
2023
American Society for Gastrointestinal Endoscopy
2016-2020
Nagoya City University
2006-2016
Nagoya University
2011-2016
Nagoya University Hospital
2011
Panasonic (Japan)
1999-2002
Gifu Municipal Hospital
1991-1999
Helicobacter pylori infection is a well-known risk factor for gastric cancer. However, the contribution of germline pathogenic variants in cancer-predisposing genes and their effect, when combined with H. infection, on cancer has not been widely evaluated.We evaluated association between 27 sample 10,426 patients 38,153 controls from BioBank Japan. We also assessed effect status calculated cumulative 1433 5997 Hospital-based Epidemiologic Research Program at Aichi Cancer Center...
4040 Background: Intraperitoneal (IP) chemotherapy is a promising treatment option for gastric cancer with peritoneal metastasis. We previously reported the safety and efficacy of IP paclitaxel (PTX) plus S-1/PTX in phase I II studies. S-1/oxaliplatin (SOX) showed non-inferiority to S-1/cisplatin PFS, considered as new standard regimen first-line advanced on an outpatient basis Japan. designed combining PTX SOX order maximize systemic effects well local cavity. The recommended dose was...
Background —The process of progression in coronary artery disease is unknown. Methods and Results subjects were 36 patients with objective vessels clinically significant (≥15% per year) whom 4 serial arteriograms (CAGs) performed at intervals ≈4 months a 1-year period. The degree percent stenosis between each 2 CAGs was classified as marked (M: ≥15%), slight (S: 5% to 14%), no (N: <5%). From the pattern progression, 14 type 1 (N→N→M 13 S→S→M vessel) 22 without (S→S→S 18 vessels, N→S→S 4)....
Using a traction device can reduce the procedure time and complications associated with colorectal endoscopic submucosal dissection (ESD) [1] [2]. We developed novel technique using multi-loop (MLTD; Boston Scientific, Tokyo, Japan) that enables at three locations; we termed this "anchor method" [3]. However, method, attachment to opposite side of intestinal tract may be difficult in places where lumen is wide, such as cecum ascending colon, because shortness device, there risk perforation...
Kato S, Takahashi E, Asano N, Tanaka T, Megahed Kinoshita T & Nakamura S (2012) Histopathology 61, 186–199 Nodal cytotoxic molecule (CM)‐positive Epstein–Barr virus (EBV)‐associated peripheral cell lymphoma (PTCL): a clinicopathological study of 26 cases Aims: The distinctiveness nodal (PTCL) remains to be clarified. We investigated patients with this compared CM + EBV − PTCL ( n = 39) and extranasal natural killer/T nasal type (ENKTL, 44). Methods results: were more likely have B...
Abstract Background Obtaining histological evidence of gallbladder carcinoma (GBC) is difficult due to its extraductal nature, and pathological confirmation remains challenging. We compared the diagnostic value safety endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) with retrograde cholangiography (ERC) in patients suspected GBC. Patients Eighty‐three GBC were evaluated. Prior definitive management, was obtained through either ERC cytopathologic sampling ( n = 33), EUS‐FNA 24)...
1. Pontine and bulbar reticular formation (RF) Deiters' nucleus were stimulated stereotaxically with brief electric stimuli (2-3msec.) their effects. on the intracellular potential of lumbar alpha motoneurons as wall size monosynaptic reflex studied in cat. Secondary effects through. gamma efferents-muscle spindle loop eliminated.2. Stimulation pontine RF, especially its rostral part, produced a marked inhibition extensor at latency 15-20msec. slight facilitation flexor about 10msec.3. was...
A genetic variant on aldehyde dehydrogenase 2 (ALDH2 rs671, Glu504Lys) contributes to carcinogenesis after alcohol consumption. Somewhat conversely, the ALDH2 Lys allele also confers a protective effect against alcohol-induced by decreasing consumption due acetaldehyde-related adverse effects. Here, we applied mediation analysis five case-control studies for head and neck, esophageal, stomach, small intestine, colorectal cancers, with 4,099 cases 6,065 controls, explored potentially...
Helicobacter pylori is an important gastrointestinal pathogen related to the development of not only atrophic gastritis and peptic ulcer, but also gastric cancer. Human leukocyte antigens (HLA) may play particular roles in host immune responses bacterial antigens. This study aimed investigate association between HLA-DQA1 DQB1 genotypes haplotypes vs H. infection Indonesian population.We selected 294 healthy participants Mataram, Lombok Island, Indonesia. was determined by urea breath test...
Because the biopsy specimen of extrahepatic bile duct carcinoma (EHBDC) is small and shows reactive changes, histological distinction between malignant benign tissue can be difficult. Recent studies reported that S100P insulin-like growth factor II mRNA-binding protein 3 (IMP3) were not only diagnostic molecules but also prognostic biomarkers in several organs. The objective this study to clarify value immunohistochemical expression IMP3 transpapillary biliary forceps (TBFB) samples.The TBFB...
Background and Aim Self‐expandable metallic stents have mainly been used for the palliation of malignant gastric outlet obstruction ( GOO ). However, their use in long‐term survivors feasibility, safety benefit additional intervention stent dysfunction remain controversial. The present study examined benefits endoscopic gastroduodenal stenting. Methods We reviewed 61 patients treated with N iti‐ S at several hospitals estimated efficacy intervention, patency, eating period factors related to...
No previous studies have described endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) only for intra-ampullary lesions of the papilla Vater. We aimed to examine whether EUS-FNA can be used diagnose such lesions.This study included a subset 10 consecutive patients in whom targeted ampulla All underwent biopsy and/or brushing cytology under retrograde cholangiopancreatography (ERCP) prior EUS-FNA. The final diagnosis was based on pathological examinations specimens obtained by...
Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoproliferation encompasses a broad range of clinicopathologic findings, including specific subtypes, for example, EBV + mucocutaneous ulcer. Here we reassessed 36 cases primary lymphomas (16 men and 20 women; median age, 69.5 y; range, 35 to 84 y), 8 immunosuppressed patients (Lugano stage II-IV; 74 7 nonimmunosuppressed with I disease (median 69 21 II-IV y). All exhibited iatrogenic immunodeficiency an ulcerative appearance, ulcer...
Abstract Background Esophageal cancer is associated with synchronous or metachronous at other primary sites. However, few studies have evaluated the second malignancies after treatment of esophageal cancer. The present study aimed to clarify frequency and risk factors for definitive therapy Patients Methods We included patients who received between 2000 2010. Exclusion criteria were a past history Standardized incidence rate (SIR) was calculated using age‐ sex‐specific rates from registry...
1. Effects of stimulation cerebellar and thalamic nuclei on the spinal function were tested by recording monosynaptic reflex discharges from ventral roots intracellular potentials alpha motoneurons in lumbar segments cat.2. The effect elicited single pulse was fairly same between animals under very light anesthesia good general conditions. However, it easily variable with a slight change animal conditions.3. Single fastigial nucleus (FN) two group facilitations upon set up tibial nerve...
Endoscopic resection is one treatment option for residual or locally recurrent esophageal cancer after definitive chemoradiotherapy radiotherapy alone. However, little known about the clinical benefit of salvage endoscopic these lesions. Therefore, effectiveness and prognostic factors were investigated.A total 37 patients with squamous cell carcinoma (SCC) who underwent alone reviewed. The method was mucosal using a cap (EMR-C), strip biopsy, submucosal dissection. retrospectively analyzed.A...