A5040553729- Soil Carbon and Nitrogen Dynamics
- Soil and Water Nutrient Dynamics
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Soil and Unsaturated Flow
- Peatlands and Wetlands Ecology
- Forest ecology and management
- Clay minerals and soil interactions
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Soil Geostatistics and Mapping
- Soil erosion and sediment transport
- Polymer Surface Interaction Studies
- 3D Printing in Biomedical Research
- Hemostasis and retained surgical items
- Ecology and Vegetation Dynamics Studies
- Surgical Sutures and Adhesives
- Nanoparticle-Based Drug Delivery
- Quantum Dots Synthesis And Properties
- Advanced biosensing and bioanalysis techniques
- Hydrology and Watershed Management Studies
- Conservation, Biodiversity, and Resource Management
- Hemoglobin structure and function
- Intestinal and Peritoneal Adhesions
- Innovative Microfluidic and Catalytic Techniques Innovation
The University of Tokyo
2016-2025
Japan Science and Technology Agency
2022-2025
Japan International Cooperation Agency
2015-2024
Institute of Engineering
2021-2024
Kyoto University
2010-2021
University of Toronto
2016-2019
Universitas Sari Mutiara Indonesia
2018
Bunkyo University
2017
Chiba Institute of Technology
2014
Forestry and Forest Products Research Institute
1983-2000
We developed an injectable gelatin/hyaluronic acid hydrogel with slow degradability, which consisted of carbohydrazide-modified gelatin (Gel-CDH) and hyaluronic monoaldehyde (HA-mCHO). Gel-CDH/HA-mCHO hydrogels were degraded much more slowly in phosphate-buffered saline than the other Schiff's base cross-linked that comprised native gelatin, adipic dihydrazide-modified or dialdehyde because stable formation between aldehyde carbohydrazide groups, suppression ring-opening oxidation by...
Precise control of biosystems requires development materials that can dynamically change physicochemical properties. Inspired by the ability proteins to alter their conformation mediate function, we explored use DNA as molecular keys assemble and transform colloidal nanoparticle systems. The systems consist a core surrounded small satellites, which be transformed in response via toe-hold displacement mechanism. conformational changes optical properties biological interactions assembled...
Abstract The blood–brain barrier (BBB) has hampered the efficiency of nanoparticle delivery into brain via conventional strategies. widening BBB tight junctions focused ultrasound (FUS) offers a promising approach for enhancing nanoparticles brain. However, there is currently an insufficient understanding how pass through opened gaps. Here we investigated size-dependence assisted by FUS-induced opening, using gold (AuNPs) 3, 15, and 120 nm diameter. For 3- 15-nm AuNPs, FUS exposure...
Injectable hydrogels are useful in biomedical applications. We have synthesized hyaluronic acids chemically modified with azide groups (HA–A) and cyclooctyne (HA–C), respectively. Aqueous HA–A HA–C solutions were mixed using a double-barreled syringe to form hydrogel via strain-promoted [3 + 2] cycloaddition without any catalyst at physiological conditions. The slowly degraded PBS over 2 weeks, which was accelerated 9 days by hyaluronidase, while it rapidly cell culture media fetal bovine...
Positron emission tomography (PET)/fluorescence dual-modal imaging combines deep penetration and high resolution, making it a promising approach for tumor diagnostics. Semiconductor nanocrystals, known as quantum dots (QDs), have garnered significant attention fluorescence owing to their tunable wavelength, yield, excellent photostability. Among these QDs, heavy metal-free InP-based QDs emerged candidate, addressing concerns regarding metal-related toxicity. However, the best of our...
Abstract An incubation experiment was conducted to examine the effects of phosphorus (P) application on nitrous oxide (N2O) and nitric (NO) emissions from soils an Acacia mangium plantation in Indonesia. The were incubated with without addition P (Ca[H2PO4]2; 2 mg g soil)−1) after adjusting water-filled pore space (WFPS) 75% or 100%. increased N2O under both WFPS conditions NO at WFPS. Some possible mechanisms are considered. First, stimulated nitrogen (N) cycling, N used for nitrification...
We have developed a new hydrogel hemostat composed of hyaluronan (HA) conjugated with inorganic polyphosphate (PolyP). A hemostatic hydrogel, HAX-PolyP, was formed rapidly by mixing aldehyde-modified HA and hydrazide-modified PolyP (HA-PolyP). Although the gelation rate decreased increasing content, time below 5 min. In addition, swelling volume but degradation did not depend on content underwent complete through hydrolysis over 3 weeks in phosphate buffered saline. HAX-PolyP showed similar...
Hyaluronan (HA) is a promising drug carrier for cancer therapy because of its CD44 targeting ability, good biocompatibility, and biodegradability. In this study, cisplatin (CDDP)-incorporating HA nanogels were fabricated through chelating ligand-metal coordination cross-linking reaction. We conjugated ligands, iminodiacetic acid or malonic acid, to used them as precursor polymer. By mixing the ligand-conjugated with CDDP, occurred via ligands platinum in resulting spontaneous formation...
We developed a new muco-adhesive hydrogel composed of cationic guar gum (CGG) and boric acid (BA). The CGG-BA precursor solution 0.5-2% w/v concentration exhibited fluidity at low pH (3-5), while gelation occurred within 1 min physiological (7-8) conditions. Scanning electron microscopy Fourier-transform infrared spectroscopy results confirmed the change in physical chemical behavior, respectively, with pH. pH-responsive self-healing ability was analyzed through rheology. hydrogels showed...
Abstract Flow cytometry can provide detailed information about protein expression on cell surface and is, therefore, widely used in clinical testing. However, owing to the limited sensitivity of fluorescence signals, detection low‐expression markers is challenging. The present report describes a DNA‐mediated, on‐membrane assembly conjugated polymer nanoparticles (Pdots) that amplifies signal from for sensitive via flow cytometry. Single‐stranded DNA (ssDNA)‐conjugated antibodies are first...
Background A number of immunotherapeutic approaches have been developed and are entering the clinic. Bispecific antibodies (BsAbs) one these modalities induce robust efficacy by endogenous T cells in several hematological malignancies. However, most treated patients experience only a temporary benefit. Currently available BsAbs provide anti-CD3 antibody-mediated T-cell stimulation, but not costimulation or cytokine signaling essential for full activation. Here, we hypothesized that...
Antibacterial and antiviral coating materials have attracted increasing attention for the prevention of infections caused by frequently touched surfaces in communities hospitals. The standard assessment procedure antibacterial involves bacterial culture on a film-covered substrate followed transfer onto agar colony counting (ISO22196:2011). However, this lacks temporal spatial information regarding growth, resulting an incomplete inaccurate evaluation activity surface. In study, we develop...